A 20s complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

Cyclin B is degraded at the onset of anaphase by a ubiquitin-dependent proteolytic system. We have fractionated mitotic Xenopus egg extracts to identify components required for this process. We find that UBC4 and at least one other ubiquitin-conjugating enzyme can support cyclin B ubiquitination. Th...

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Veröffentlicht in:	Cell 1995-04, Vol.81 (2), p.279-288
Hauptverfasser:	King, Randall W, Peters, Jan-Michael, Tugendreich, Stuart, Rolfe, Mark, Hieter, Philip, Kirschner, Marc W
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphase - physiology Animals Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome Cell Cycle Proteins - metabolism Cyclins - metabolism Freshwater Ligases - analysis Ligases - genetics Ligases - metabolism Macromolecular Substances Mitosis - physiology Ovum Recombinant Proteins - pharmacology Saccharomyces cerevisiae Proteins Subcellular Fractions - metabolism Ubiquitin-Activating Enzymes Ubiquitin-Conjugating Enzymes Ubiquitin-Protein Ligases Ubiquitins - metabolism Xenopus
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