Entorhinal-Perirhinal Lesions Impair Performance of Rats on Two Versions of Place Learning in the Morris Water Maze
The effects of entorhinal-perirhinal lesions in rats were studied with 2 versions of a place learning task in the Morris water maze. These lesions impaired performance on a multiple-trial task (3 days of 6 trials and a probe trial). This assessment was followed by a task in which rats were repeatedl...
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| Veröffentlicht in: | Behavioral neuroscience 1995-02, Vol.109 (1), p.3-9 |
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| creator | Nagahara, Alan H Otto, Tim Gallagher, Michela |
| description | The effects of entorhinal-perirhinal lesions in rats were studied with 2 versions of a place learning task in the Morris water maze. These lesions impaired performance on a multiple-trial task (3 days of 6 trials and a probe trial). This assessment was followed by a task in which rats were repeatedly trained to find novel locations with a variable delay (30 s or 5 min) imposed between each sample trial and retention test. Entorhinal-perirhinal damage produced a delay-dependent deficit in spatial memory: Rats with lesions were impaired at the 5-min delay relative to the control group and to their own performance at 30 s. These findings are discussed in relationship to memory impairment after entorhinal damage and spatial learning deficits observed after hippocampal damage. |
| doi_str_mv | 10.1037/0735-7044.109.1.3 |
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These lesions impaired performance on a multiple-trial task (3 days of 6 trials and a probe trial). This assessment was followed by a task in which rats were repeatedly trained to find novel locations with a variable delay (30 s or 5 min) imposed between each sample trial and retention test. Entorhinal-perirhinal damage produced a delay-dependent deficit in spatial memory: Rats with lesions were impaired at the 5-min delay relative to the control group and to their own performance at 30 s. These findings are discussed in relationship to memory impairment after entorhinal damage and spatial learning deficits observed after hippocampal damage.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/0735-7044.109.1.3</identifier><identifier>PMID: 7734077</identifier><identifier>CODEN: BENEDJ</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Anatomical correlates of behavior ; Animal ; Animal memory ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Brain ; Brain Mapping ; Entorhinal Cortex - physiology ; Fundamental and applied biological sciences. Psychology ; Hippocampus ; Hippocampus - physiology ; Learning ; Limbic System ; Male ; Maze Learning - physiology ; Memory, Short-Term - physiology ; Mental Recall - physiology ; Neurons - physiology ; Orientation - physiology ; Place Conditioning ; Psychology. 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These lesions impaired performance on a multiple-trial task (3 days of 6 trials and a probe trial). This assessment was followed by a task in which rats were repeatedly trained to find novel locations with a variable delay (30 s or 5 min) imposed between each sample trial and retention test. Entorhinal-perirhinal damage produced a delay-dependent deficit in spatial memory: Rats with lesions were impaired at the 5-min delay relative to the control group and to their own performance at 30 s. These findings are discussed in relationship to memory impairment after entorhinal damage and spatial learning deficits observed after hippocampal damage.</description><subject>Anatomical correlates of behavior</subject><subject>Animal</subject><subject>Animal memory</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain Mapping</subject><subject>Entorhinal Cortex - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Hippocampus - physiology</subject><subject>Learning</subject><subject>Limbic System</subject><subject>Male</subject><subject>Maze Learning - physiology</subject><subject>Memory, Short-Term - physiology</subject><subject>Mental Recall - physiology</subject><subject>Neurons - physiology</subject><subject>Orientation - physiology</subject><subject>Place Conditioning</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Retention (Psychology) - physiology</subject><subject>Rodents</subject><subject>Spatial Learning</subject><subject>Spatial Memory</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFDEUhoModa3-AC-EoOKFMGsyySSbSylVC1ssUvUynEnP2JTZZJrMIPXXm2GWRUX06pyT9zkf5CXkKWdrzoR-w7RoKs2kLKVZ87W4R1bcCFMxtpH3yeqgPySPcr5hjEkmmyNypLWQTOsVyadhjOnaB-irC0x-SekWs48h07PdAD7RonQx7SA4pLGjn2DMNAZ6-T3SL5gWtLxf9FCALUIKPnyjPtDxGul5TMln-hVGTPQcfuBj8qCDPuOTfTwmn9-dXp58qLYf35-dvN1WUI4bK6Vax1F2yoHoEGrUrOV1K9pGK601cnmlFIO6M9Cg0dw5pjfGNUZo1RjVimPyapk7pHg7YR7tzmeHfQ8B45St1rWUWpn_glxtWL2pZQGf_wHexCmVD8tWcSm4qP8N1UwYpiQXBeIL5FLMOWFnh-R3kO4sZ3b21s7e2dm7UhrL7dzzbD94and4dejYm1n0l3sdsoO-S8Uvnw-YkM18YcFeLxgMYId85yCN3vWY3ZQShtG2AX_Z-eLv8G_UT8TlxWE</recordid><startdate>199502</startdate><enddate>199502</enddate><creator>Nagahara, Alan H</creator><creator>Otto, Tim</creator><creator>Gallagher, Michela</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>199502</creationdate><title>Entorhinal-Perirhinal Lesions Impair Performance of Rats on Two Versions of Place Learning in the Morris Water Maze</title><author>Nagahara, Alan H ; Otto, Tim ; Gallagher, Michela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a340t-66bc1e4f6ca3fea2e70b12b3b576777e14d660a2f9a5e971cc0789c59376596b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Anatomical correlates of behavior</topic><topic>Animal</topic><topic>Animal memory</topic><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain Mapping</topic><topic>Entorhinal Cortex - physiology</topic><topic>Fundamental and applied biological sciences. 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Psychophysiology</topic><topic>Rats</topic><topic>Retention (Psychology) - physiology</topic><topic>Rodents</topic><topic>Spatial Learning</topic><topic>Spatial Memory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagahara, Alan H</creatorcontrib><creatorcontrib>Otto, Tim</creatorcontrib><creatorcontrib>Gallagher, Michela</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagahara, Alan H</au><au>Otto, Tim</au><au>Gallagher, Michela</au><au>Squire, Larry R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Entorhinal-Perirhinal Lesions Impair Performance of Rats on Two Versions of Place Learning in the Morris Water Maze</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>1995-02</date><risdate>1995</risdate><volume>109</volume><issue>1</issue><spage>3</spage><epage>9</epage><pages>3-9</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><coden>BENEDJ</coden><abstract>The effects of entorhinal-perirhinal lesions in rats were studied with 2 versions of a place learning task in the Morris water maze. These lesions impaired performance on a multiple-trial task (3 days of 6 trials and a probe trial). This assessment was followed by a task in which rats were repeatedly trained to find novel locations with a variable delay (30 s or 5 min) imposed between each sample trial and retention test. Entorhinal-perirhinal damage produced a delay-dependent deficit in spatial memory: Rats with lesions were impaired at the 5-min delay relative to the control group and to their own performance at 30 s. These findings are discussed in relationship to memory impairment after entorhinal damage and spatial learning deficits observed after hippocampal damage.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>7734077</pmid><doi>10.1037/0735-7044.109.1.3</doi><tpages>7</tpages></addata></record> |
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| ispartof | Behavioral neuroscience, 1995-02, Vol.109 (1), p.3-9 |
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| source | MEDLINE; EBSCOhost APA PsycARTICLES |
| subjects | Anatomical correlates of behavior Animal Animal memory Animals Behavioral psychophysiology Biological and medical sciences Brain Brain Mapping Entorhinal Cortex - physiology Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - physiology Learning Limbic System Male Maze Learning - physiology Memory, Short-Term - physiology Mental Recall - physiology Neurons - physiology Orientation - physiology Place Conditioning Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Retention (Psychology) - physiology Rodents Spatial Learning Spatial Memory |
| title | Entorhinal-Perirhinal Lesions Impair Performance of Rats on Two Versions of Place Learning in the Morris Water Maze |
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