Hypertension and Lens Opacities From the Beaver Dam Eye Study
To examine the relationship between hypertension and lens opacities, and the use of antihypertensive agents. A total of 4,926 adults, 43 to 84 years of age, living in Beaver Dam, Wisconsin, at the time of a private census, were invited to participate in a study that included a medical interview and...
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| Veröffentlicht in: | American journal of ophthalmology 1995-05, Vol.119 (5), p.640-646 |
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| container_end_page | 646 |
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| container_title | American journal of ophthalmology |
| container_volume | 119 |
| creator | KLEIN, BARBARA E.K. KLEIN, RONALD JENSEN, SUSAN C. LINTON, KATHRYN L.P. |
| description | To examine the relationship between hypertension and lens opacities, and the use of antihypertensive agents.
A total of 4,926 adults, 43 to 84 years of age, living in Beaver Dam, Wisconsin, at the time of a private census, were invited to participate in a study that included a medical interview and an examination that included ocular photography. All study procedures and photographic grading were done according to standard protocols.
According to analysis with the Liang-Zeger multiple logistic regression model, people with hypertension were more likely to have posterior subcapsular opacities than people without hypertension (odds ratio, 1.39; 95% confidence interval, 1.05, 1.84). Specific medications for hypertension did not meaningfully affect the risk. Hypertension was associated with increased risk in both those with and without diabetes.
Hypertension is associated with increased risk of posterior subcapsular opacities. The pathophysiologic mechanisms that may explain the relationship are unknown. Incidence data will give a better indication of temporal relationship between hypertension, medications to lower blood pressure, and lens opacities. |
| doi_str_mv | 10.1016/S0002-9394(14)70223-5 |
| format | Article |
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A total of 4,926 adults, 43 to 84 years of age, living in Beaver Dam, Wisconsin, at the time of a private census, were invited to participate in a study that included a medical interview and an examination that included ocular photography. All study procedures and photographic grading were done according to standard protocols.
According to analysis with the Liang-Zeger multiple logistic regression model, people with hypertension were more likely to have posterior subcapsular opacities than people without hypertension (odds ratio, 1.39; 95% confidence interval, 1.05, 1.84). Specific medications for hypertension did not meaningfully affect the risk. Hypertension was associated with increased risk in both those with and without diabetes.
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A total of 4,926 adults, 43 to 84 years of age, living in Beaver Dam, Wisconsin, at the time of a private census, were invited to participate in a study that included a medical interview and an examination that included ocular photography. All study procedures and photographic grading were done according to standard protocols.
According to analysis with the Liang-Zeger multiple logistic regression model, people with hypertension were more likely to have posterior subcapsular opacities than people without hypertension (odds ratio, 1.39; 95% confidence interval, 1.05, 1.84). Specific medications for hypertension did not meaningfully affect the risk. Hypertension was associated with increased risk in both those with and without diabetes.
Hypertension is associated with increased risk of posterior subcapsular opacities. The pathophysiologic mechanisms that may explain the relationship are unknown. Incidence data will give a better indication of temporal relationship between hypertension, medications to lower blood pressure, and lens opacities.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cataract - epidemiology</subject><subject>Cataract - etiology</subject><subject>Cataract - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - epidemiology</subject><subject>Lens Capsule, Crystalline - pathology</subject><subject>Lens diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Ophthalmology</subject><subject>Risk Factors</subject><subject>Wisconsin - epidemiology</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotVZ_QiEHET2sJpvNZnMQ0VqtUOiheg5pMsFId7cmu4X-e7cf9OppMrzPzIQHoSEl95TQ_GFOCEkTyWR2S7M7QdKUJfwE9WkhZEILSU9R_4ico4sYf7o2F5nooZ4QjFFJ-uhxsllBaKCKvq6wriyedm88W2njGw8Rv4W6xM034BfQawj4VZd4vAE8b1q7uURnTi8jXB3qAH29jT9Hk2Q6e_8YPU8TwwrZJEandkFzk0ngqZGOO6Ft1y6s0zyjTJi0WKTcuYIbkVvDCyqM61ICGWgp2ADd7PeuQv3bQmxU6aOB5VJXULdRCZFmLCeyA_keNKGOMYBTq-BLHTaKErXVpnba1NaJopnaaVO8mxseDrSLEuxx6uCpy68PuY5GL13QlfHxiDFOc86255_2GHQy1h6CisZDZcD6AKZRtvb_fOQPoFyI2A</recordid><startdate>19950501</startdate><enddate>19950501</enddate><creator>KLEIN, BARBARA E.K.</creator><creator>KLEIN, RONALD</creator><creator>JENSEN, SUSAN C.</creator><creator>LINTON, KATHRYN L.P.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950501</creationdate><title>Hypertension and Lens Opacities From the Beaver Dam Eye Study</title><author>KLEIN, BARBARA E.K. ; KLEIN, RONALD ; JENSEN, SUSAN C. ; LINTON, KATHRYN L.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-ca2db16c49e52c9f5f7ad6c4bdfa54137c28b25ff85c76dc5817cfbdf0e4ea973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cataract - epidemiology</topic><topic>Cataract - etiology</topic><topic>Cataract - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - epidemiology</topic><topic>Lens Capsule, Crystalline - pathology</topic><topic>Lens diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Ophthalmology</topic><topic>Risk Factors</topic><topic>Wisconsin - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KLEIN, BARBARA E.K.</creatorcontrib><creatorcontrib>KLEIN, RONALD</creatorcontrib><creatorcontrib>JENSEN, SUSAN C.</creatorcontrib><creatorcontrib>LINTON, KATHRYN L.P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KLEIN, BARBARA E.K.</au><au>KLEIN, RONALD</au><au>JENSEN, SUSAN C.</au><au>LINTON, KATHRYN L.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypertension and Lens Opacities From the Beaver Dam Eye Study</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>1995-05-01</date><risdate>1995</risdate><volume>119</volume><issue>5</issue><spage>640</spage><epage>646</epage><pages>640-646</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>To examine the relationship between hypertension and lens opacities, and the use of antihypertensive agents.
A total of 4,926 adults, 43 to 84 years of age, living in Beaver Dam, Wisconsin, at the time of a private census, were invited to participate in a study that included a medical interview and an examination that included ocular photography. All study procedures and photographic grading were done according to standard protocols.
According to analysis with the Liang-Zeger multiple logistic regression model, people with hypertension were more likely to have posterior subcapsular opacities than people without hypertension (odds ratio, 1.39; 95% confidence interval, 1.05, 1.84). Specific medications for hypertension did not meaningfully affect the risk. Hypertension was associated with increased risk in both those with and without diabetes.
Hypertension is associated with increased risk of posterior subcapsular opacities. The pathophysiologic mechanisms that may explain the relationship are unknown. Incidence data will give a better indication of temporal relationship between hypertension, medications to lower blood pressure, and lens opacities.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>7733190</pmid><doi>10.1016/S0002-9394(14)70223-5</doi><tpages>7</tpages></addata></record> |
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| ispartof | American journal of ophthalmology, 1995-05, Vol.119 (5), p.640-646 |
| issn | 0002-9394 1879-1891 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adult Aged Aged, 80 and over Antihypertensive Agents - therapeutic use Biological and medical sciences Blood Pressure - drug effects Cataract - epidemiology Cataract - etiology Cataract - pathology Female Humans Hypertension - complications Hypertension - drug therapy Hypertension - epidemiology Lens Capsule, Crystalline - pathology Lens diseases Male Medical sciences Middle Aged Odds Ratio Ophthalmology Risk Factors Wisconsin - epidemiology |
| title | Hypertension and Lens Opacities From the Beaver Dam Eye Study |
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