Cloning, expression and functional characterization of type 1 and type 2 steroid 5α-reductases from Cynomolgus monkey: Comparisons with human and rat isoenzymes

The Cynomolgus monkey may provide an alternative pharmacological model in which to evaluate the efficacy of novel inhibitors of the two known human steroid 5α-reductase (SR) isoenzymes. To evaluate the suitability of this species at the level of the molecular targets, a Cynomolgus monkey prostate cD...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 1995-04, Vol.52 (4), p.307-319
Hauptverfasser:	Levy, Mark A., Brandt, Martin, Sheedy, Kristina M., Holt, Dennis A., Heaslip, Julie I., Trill, John J., Ryan, Paul J., Morris, RenéA., Garrison, Linda M., Bergsma, Derk J.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Oxo-5-alpha-Steroid 4-Dehydrogenase - classification 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism 5-alpha Reductase Inhibitors Amino Acid Sequence Analytical, structural and metabolic biochemistry Animals Base Sequence Biological and medical sciences Blotting, Northern Cloning, Molecular Cynomolgus DNA, Complementary - genetics Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Gene Expression Humans Hydrogen-Ion Concentration Isoenzymes - genetics Macaca fascicularis Male Molecular Sequence Data Oxidoreductases Prostate - enzymology Rats Recombinant Proteins - metabolism RNA, Messenger - genetics Sequence Analysis, DNA Sequence Homology, Amino Acid Steroids - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!