Effect of extremely-low-frequency pulsed magnetic fields on the mitogenic response of peripheral blood mononuclear cells
The effect of extremely‐low‐frequency pulsed magnetic fields (PMF) on the response of human peripheral blood mononuclear cells to mitogenic stimulation is reported. We investigated 25 healthy control subjects. Mitogen‐stimulated mononuclear cells were exposed to PMF for 72 h and an inhibition of 3H‐...
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| Veröffentlicht in: | Bioelectromagnetics 1986, Vol.7 (4), p.387-394 |
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| creator | Mooney, Nuala A. Smith, Roy E. Watson, Bernard W. |
| description | The effect of extremely‐low‐frequency pulsed magnetic fields (PMF) on the response of human peripheral blood mononuclear cells to mitogenic stimulation is reported. We investigated 25 healthy control subjects. Mitogen‐stimulated mononuclear cells were exposed to PMF for 72 h and an inhibition of 3H‐thymidine uptake was observed in all but one subject. The degree of inhibition of 3H‐thymidine uptake was as much as 60%. There was no significant difference between the blastogenic responses of mononuclear cells exposed to PMF for 12 h and control cultures. This study establishes an inhibitory effect of PMF on an in vitro measure of immune function. |
| doi_str_mv | 10.1002/bem.2250070406 |
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We investigated 25 healthy control subjects. Mitogen‐stimulated mononuclear cells were exposed to PMF for 72 h and an inhibition of 3H‐thymidine uptake was observed in all but one subject. The degree of inhibition of 3H‐thymidine uptake was as much as 60%. There was no significant difference between the blastogenic responses of mononuclear cells exposed to PMF for 12 h and control cultures. This study establishes an inhibitory effect of PMF on an in vitro measure of immune function.</description><identifier>ISSN: 0197-8462</identifier><identifier>EISSN: 1521-186X</identifier><identifier>DOI: 10.1002/bem.2250070406</identifier><identifier>PMID: 3801062</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>550201 -- Biochemistry-- Tracer Techniques ; Adult ; ANIMAL CELLS ; ANIMALS ; AZINES ; BASIC BIOLOGICAL SCIENCES ; BIOLOGICAL EFFECTS ; BIOLOGICAL MATERIALS ; BLOOD ; BLOOD CELLS ; BODY FLUIDS ; CONNECTIVE TISSUE CELLS ; ELECTROMAGNETIC FIELDS ; Electromagnetic Phenomena ; extremely-low-frequency magnetic fields ; Female ; HETEROCYCLIC COMPOUNDS ; Humans ; IMMUNE REACTIONS ; INHIBITION ; ISOTOPE APPLICATIONS ; LABELLED COMPOUNDS ; LEUKOCYTES ; Lymphocyte Activation - radiation effects ; LYMPHOCYTES ; Lymphocytes - radiation effects ; Male ; MAMMALS ; MAN ; MATERIALS ; mitogenic response ; MONOCYTES ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC COMPOUNDS ; ORGANIC NITROGEN COMPOUNDS ; peripheral blood mononuclear cells ; PRIMATES ; PYRIMIDINES ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RIBOSIDES ; SOMATIC CELLS ; THYMIDINE ; Thymidine - metabolism ; Time Factors ; TRACER TECHNIQUES ; Tritium ; TRITIUM COMPOUNDS ; UPTAKE ; VERTEBRATES 560400 -- Other Environmental Pollutant Effects</subject><ispartof>Bioelectromagnetics, 1986, Vol.7 (4), p.387-394</ispartof><rights>Copyright © 1986 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4056-9221798157745db4ff8f43beac0ce7ac5395b5e422ad7098f2632f224f6774553</citedby><cites>FETCH-LOGICAL-c4056-9221798157745db4ff8f43beac0ce7ac5395b5e422ad7098f2632f224f6774553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbem.2250070406$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbem.2250070406$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,881,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3801062$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6926573$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Mooney, Nuala A.</creatorcontrib><creatorcontrib>Smith, Roy E.</creatorcontrib><creatorcontrib>Watson, Bernard W.</creatorcontrib><creatorcontrib>St. Bartholomew's Hospital, London, England</creatorcontrib><title>Effect of extremely-low-frequency pulsed magnetic fields on the mitogenic response of peripheral blood mononuclear cells</title><title>Bioelectromagnetics</title><addtitle>Bioelectromagnetics</addtitle><description>The effect of extremely‐low‐frequency pulsed magnetic fields (PMF) on the response of human peripheral blood mononuclear cells to mitogenic stimulation is reported. We investigated 25 healthy control subjects. Mitogen‐stimulated mononuclear cells were exposed to PMF for 72 h and an inhibition of 3H‐thymidine uptake was observed in all but one subject. The degree of inhibition of 3H‐thymidine uptake was as much as 60%. There was no significant difference between the blastogenic responses of mononuclear cells exposed to PMF for 12 h and control cultures. This study establishes an inhibitory effect of PMF on an in vitro measure of immune function.</description><subject>550201 -- Biochemistry-- Tracer Techniques</subject><subject>Adult</subject><subject>ANIMAL CELLS</subject><subject>ANIMALS</subject><subject>AZINES</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL MATERIALS</subject><subject>BLOOD</subject><subject>BLOOD CELLS</subject><subject>BODY FLUIDS</subject><subject>CONNECTIVE TISSUE CELLS</subject><subject>ELECTROMAGNETIC FIELDS</subject><subject>Electromagnetic Phenomena</subject><subject>extremely-low-frequency magnetic fields</subject><subject>Female</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>Humans</subject><subject>IMMUNE REACTIONS</subject><subject>INHIBITION</subject><subject>ISOTOPE APPLICATIONS</subject><subject>LABELLED COMPOUNDS</subject><subject>LEUKOCYTES</subject><subject>Lymphocyte Activation - radiation effects</subject><subject>LYMPHOCYTES</subject><subject>Lymphocytes - radiation effects</subject><subject>Male</subject><subject>MAMMALS</subject><subject>MAN</subject><subject>MATERIALS</subject><subject>mitogenic response</subject><subject>MONOCYTES</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC NITROGEN COMPOUNDS</subject><subject>peripheral blood mononuclear cells</subject><subject>PRIMATES</subject><subject>PYRIMIDINES</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RIBOSIDES</subject><subject>SOMATIC CELLS</subject><subject>THYMIDINE</subject><subject>Thymidine - metabolism</subject><subject>Time Factors</subject><subject>TRACER TECHNIQUES</subject><subject>Tritium</subject><subject>TRITIUM COMPOUNDS</subject><subject>UPTAKE</subject><subject>VERTEBRATES 560400 -- Other Environmental Pollutant Effects</subject><issn>0197-8462</issn><issn>1521-186X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQRiMEKkvhyg3J4sAti-3EdnKEammR2sIB2t4sxxl3DY6d2om6--_xKqsiTpwszbzvyaOvKN4SvCYY048dDGtKGcYC15g_K1aEUVKSht89L1aYtKJsak5fFq9S-oUxbhpcnRQnVYMJ5nRV7DbGgJ5QMAh2U4QB3L504bE0ER5m8HqPxtkl6NGg7j1MViNjwfUJBY-mLaDBTuEefJ5HSGPwCQ6uEaIdtxCVQ50LIaeDD37WDlREGpxLr4sXRmXxm-N7Wvz8svlxdlFefjv_evbpstQ1ZrxsKSWibQgTomZ9VxvTmLrqQGmsQSjNqpZ1DGpKVS9w2xjKK2oorQ0_JFh1WrxfvCFNViZtJ9BbHbzPV0veUs5ElaEPCzTGkK9OkxxsOnxTeQhzkkLQGjecZ3C9gDqGlCIYOUY7qLiXBMtDHzL3If_2kQPvjua5G6B_wo8F5H277B-tg_1_bPLz5uofd7lkbZpg95RV8bfkohJM3l6fS3p1cXfz_eZa3lZ_AEhPpx8</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>Mooney, Nuala A.</creator><creator>Smith, Roy E.</creator><creator>Watson, Bernard W.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>1986</creationdate><title>Effect of extremely-low-frequency pulsed magnetic fields on the mitogenic response of peripheral blood mononuclear cells</title><author>Mooney, Nuala A. ; Smith, Roy E. ; Watson, Bernard W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4056-9221798157745db4ff8f43beac0ce7ac5395b5e422ad7098f2632f224f6774553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>550201 -- Biochemistry-- Tracer Techniques</topic><topic>Adult</topic><topic>ANIMAL CELLS</topic><topic>ANIMALS</topic><topic>AZINES</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL MATERIALS</topic><topic>BLOOD</topic><topic>BLOOD CELLS</topic><topic>BODY FLUIDS</topic><topic>CONNECTIVE TISSUE CELLS</topic><topic>ELECTROMAGNETIC FIELDS</topic><topic>Electromagnetic Phenomena</topic><topic>extremely-low-frequency magnetic fields</topic><topic>Female</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>Humans</topic><topic>IMMUNE REACTIONS</topic><topic>INHIBITION</topic><topic>ISOTOPE APPLICATIONS</topic><topic>LABELLED COMPOUNDS</topic><topic>LEUKOCYTES</topic><topic>Lymphocyte Activation - radiation effects</topic><topic>LYMPHOCYTES</topic><topic>Lymphocytes - radiation effects</topic><topic>Male</topic><topic>MAMMALS</topic><topic>MAN</topic><topic>MATERIALS</topic><topic>mitogenic response</topic><topic>MONOCYTES</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC NITROGEN COMPOUNDS</topic><topic>peripheral blood mononuclear cells</topic><topic>PRIMATES</topic><topic>PYRIMIDINES</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RIBOSIDES</topic><topic>SOMATIC CELLS</topic><topic>THYMIDINE</topic><topic>Thymidine - metabolism</topic><topic>Time Factors</topic><topic>TRACER TECHNIQUES</topic><topic>Tritium</topic><topic>TRITIUM COMPOUNDS</topic><topic>UPTAKE</topic><topic>VERTEBRATES 560400 -- Other Environmental Pollutant Effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mooney, Nuala A.</creatorcontrib><creatorcontrib>Smith, Roy E.</creatorcontrib><creatorcontrib>Watson, Bernard W.</creatorcontrib><creatorcontrib>St. Bartholomew's Hospital, London, England</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Bioelectromagnetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mooney, Nuala A.</au><au>Smith, Roy E.</au><au>Watson, Bernard W.</au><aucorp>St. Bartholomew's Hospital, London, England</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of extremely-low-frequency pulsed magnetic fields on the mitogenic response of peripheral blood mononuclear cells</atitle><jtitle>Bioelectromagnetics</jtitle><addtitle>Bioelectromagnetics</addtitle><date>1986</date><risdate>1986</risdate><volume>7</volume><issue>4</issue><spage>387</spage><epage>394</epage><pages>387-394</pages><issn>0197-8462</issn><eissn>1521-186X</eissn><abstract>The effect of extremely‐low‐frequency pulsed magnetic fields (PMF) on the response of human peripheral blood mononuclear cells to mitogenic stimulation is reported. We investigated 25 healthy control subjects. Mitogen‐stimulated mononuclear cells were exposed to PMF for 72 h and an inhibition of 3H‐thymidine uptake was observed in all but one subject. The degree of inhibition of 3H‐thymidine uptake was as much as 60%. There was no significant difference between the blastogenic responses of mononuclear cells exposed to PMF for 12 h and control cultures. This study establishes an inhibitory effect of PMF on an in vitro measure of immune function.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>3801062</pmid><doi>10.1002/bem.2250070406</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0197-8462 |
| ispartof | Bioelectromagnetics, 1986, Vol.7 (4), p.387-394 |
| issn | 0197-8462 1521-186X |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | 550201 -- Biochemistry-- Tracer Techniques Adult ANIMAL CELLS ANIMALS AZINES BASIC BIOLOGICAL SCIENCES BIOLOGICAL EFFECTS BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BODY FLUIDS CONNECTIVE TISSUE CELLS ELECTROMAGNETIC FIELDS Electromagnetic Phenomena extremely-low-frequency magnetic fields Female HETEROCYCLIC COMPOUNDS Humans IMMUNE REACTIONS INHIBITION ISOTOPE APPLICATIONS LABELLED COMPOUNDS LEUKOCYTES Lymphocyte Activation - radiation effects LYMPHOCYTES Lymphocytes - radiation effects Male MAMMALS MAN MATERIALS mitogenic response MONOCYTES NUCLEOSIDES NUCLEOTIDES ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS peripheral blood mononuclear cells PRIMATES PYRIMIDINES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RIBOSIDES SOMATIC CELLS THYMIDINE Thymidine - metabolism Time Factors TRACER TECHNIQUES Tritium TRITIUM COMPOUNDS UPTAKE VERTEBRATES 560400 -- Other Environmental Pollutant Effects |
| title | Effect of extremely-low-frequency pulsed magnetic fields on the mitogenic response of peripheral blood mononuclear cells |
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