DNA-protein crosslinking by heavy metals in Novikoff hepatoma

Crosslinking of proteins to DNA was studied in live intact Novikoff ascites hepatoma cells exposed in vitro to salts of chromium VI, III, and II, nickel II, cadmium II, and to CoCl 2, As 2O 3, and AlK(SO 4) 2. DNA-protein complexes were separated by high-speed centrifugation of cells solubilized in...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1986-12, Vol.251 (2), p.397-402
Hauptverfasser:	Wedrychowski, Andrzej, Schmidt, Warren N., Hnilica, Lubomir S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aluminum - pharmacology Animals Applied sciences Arsenic - pharmacology Cadmium - pharmacology Chromium - pharmacology Cobalt - pharmacology Cross-Linking Reagents DNA, Neoplasm - metabolism Exact sciences and technology Liver Neoplasms, Experimental - metabolism Male Metals - pharmacology Neoplasm Proteins - metabolism Nickel - pharmacology Other techniques and industries Protein Binding - drug effects Rats Rats, Inbred Strains
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