Suppression of experimental allergic encephalomyelitis in offspring of DA and Wistar rats following immunization of mother with encephalitogen
Immunization of female rats with encephalitogen before gestation, during gestation, and during lactation differentially decreased susceptibility to experimental allergic encephalomyelitis (EAE) in their offspring. The most pronounced suppression, revealed by lowered incidence and weaker clinical sig...
Gespeichert in:
| Veröffentlicht in: | Journal of neuroimmunology 1995-04, Vol.58 (1), p.43-50 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 50 |
|---|---|
| container_issue | 1 |
| container_start_page | 43 |
| container_title | Journal of neuroimmunology |
| container_volume | 58 |
| creator | Dimitrijević, M Marković, B M Laban, O Janković, B D |
| description | Immunization of female rats with encephalitogen before gestation, during gestation, and during lactation differentially decreased susceptibility to experimental allergic encephalomyelitis (EAE) in their offspring. The most pronounced suppression, revealed by lowered incidence and weaker clinical signs of the disease, was observed in offspring of mothers immunized before gestation and during lactation in both Dark August (EAE-susceptible), and Wistar (EAE-relatively resistant) rat strains. Induction of EAE in mothers during pregnancy only delayed the onset of the disease in DA progeny. The overall effect on EAE in offspring did not depend on the disease intensity in mothers. Our results suggest that anti-myelin basic protein (MBP) antibodies passively transferred from mothers are not responsible for the observed protection in offspring. |
| doi_str_mv | 10.1016/0165-5728(94)00186-R |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_77238645</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77238645</sourcerecordid><originalsourceid>FETCH-LOGICAL-p138t-55371918b7f6ed596bfaa521262ad7e8b16ade96240c790dafd734dd75bfef323</originalsourceid><addsrcrecordid>eNo9kMtOwzAQRb0AlVL4A5C8QrAIxEkcJ8uqPKVKSDzEMnLicWvk2MF2VMpH8M2kIupiNNLcM3ceCJ2R-JrEJL8ZgkaUJcVlmV3FMSny6OUATfflI3Ts_ecg0DQrJ2jCaMoSVk7R72vfdQ68V9ZgKzF8d-BUCyZwjbnW4FaqwWAa6NZc23YLWgXlsdrR0ndOmdWu73aOuRH4Q_nAHXY8eCyt1naz01Xb9kb98DAOaW1Yg8MbFdZ7axXsCswJOpRcezgd8wy939-9LR6j5fPD02K-jDqSFiGiw_qkJEXNZA6ClnktOacJSfKECwZFTXIuoMyTLG5YGQsuBUszIRitJcg0SWfo4t-3c_arBx-qVvkGtOYGbO8rxpK0yDM6gOcj2NctiGo4uOVuW40PTP8A3zN17Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77238645</pqid></control><display><type>article</type><title>Suppression of experimental allergic encephalomyelitis in offspring of DA and Wistar rats following immunization of mother with encephalitogen</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Dimitrijević, M ; Marković, B M ; Laban, O ; Janković, B D</creator><creatorcontrib>Dimitrijević, M ; Marković, B M ; Laban, O ; Janković, B D</creatorcontrib><description>Immunization of female rats with encephalitogen before gestation, during gestation, and during lactation differentially decreased susceptibility to experimental allergic encephalomyelitis (EAE) in their offspring. The most pronounced suppression, revealed by lowered incidence and weaker clinical signs of the disease, was observed in offspring of mothers immunized before gestation and during lactation in both Dark August (EAE-susceptible), and Wistar (EAE-relatively resistant) rat strains. Induction of EAE in mothers during pregnancy only delayed the onset of the disease in DA progeny. The overall effect on EAE in offspring did not depend on the disease intensity in mothers. Our results suggest that anti-myelin basic protein (MBP) antibodies passively transferred from mothers are not responsible for the observed protection in offspring.</description><identifier>ISSN: 0165-5728</identifier><identifier>DOI: 10.1016/0165-5728(94)00186-R</identifier><identifier>PMID: 7537279</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Animals ; Antibodies, Anti-Idiotypic - blood ; Disease Susceptibility - immunology ; Drug Administration Schedule ; Encephalomyelitis, Autoimmune, Experimental - immunology ; Encephalomyelitis, Autoimmune, Experimental - prevention & control ; Female ; Immunity, Innate - immunology ; Immunity, Maternally-Acquired ; Immunization Schedule ; Lactation - immunology ; Male ; Myelin Basic Protein - administration & dosage ; Myelin Basic Protein - immunology ; Pregnancy ; Rats ; Rats, Inbred Strains ; Rats, Wistar ; Species Specificity</subject><ispartof>Journal of neuroimmunology, 1995-04, Vol.58 (1), p.43-50</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7537279$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dimitrijević, M</creatorcontrib><creatorcontrib>Marković, B M</creatorcontrib><creatorcontrib>Laban, O</creatorcontrib><creatorcontrib>Janković, B D</creatorcontrib><title>Suppression of experimental allergic encephalomyelitis in offspring of DA and Wistar rats following immunization of mother with encephalitogen</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Immunization of female rats with encephalitogen before gestation, during gestation, and during lactation differentially decreased susceptibility to experimental allergic encephalomyelitis (EAE) in their offspring. The most pronounced suppression, revealed by lowered incidence and weaker clinical signs of the disease, was observed in offspring of mothers immunized before gestation and during lactation in both Dark August (EAE-susceptible), and Wistar (EAE-relatively resistant) rat strains. Induction of EAE in mothers during pregnancy only delayed the onset of the disease in DA progeny. The overall effect on EAE in offspring did not depend on the disease intensity in mothers. Our results suggest that anti-myelin basic protein (MBP) antibodies passively transferred from mothers are not responsible for the observed protection in offspring.</description><subject>Animals</subject><subject>Antibodies, Anti-Idiotypic - blood</subject><subject>Disease Susceptibility - immunology</subject><subject>Drug Administration Schedule</subject><subject>Encephalomyelitis, Autoimmune, Experimental - immunology</subject><subject>Encephalomyelitis, Autoimmune, Experimental - prevention & control</subject><subject>Female</subject><subject>Immunity, Innate - immunology</subject><subject>Immunity, Maternally-Acquired</subject><subject>Immunization Schedule</subject><subject>Lactation - immunology</subject><subject>Male</subject><subject>Myelin Basic Protein - administration & dosage</subject><subject>Myelin Basic Protein - immunology</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Rats, Wistar</subject><subject>Species Specificity</subject><issn>0165-5728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRb0AlVL4A5C8QrAIxEkcJ8uqPKVKSDzEMnLicWvk2MF2VMpH8M2kIupiNNLcM3ceCJ2R-JrEJL8ZgkaUJcVlmV3FMSny6OUATfflI3Ts_ecg0DQrJ2jCaMoSVk7R72vfdQ68V9ZgKzF8d-BUCyZwjbnW4FaqwWAa6NZc23YLWgXlsdrR0ndOmdWu73aOuRH4Q_nAHXY8eCyt1naz01Xb9kb98DAOaW1Yg8MbFdZ7axXsCswJOpRcezgd8wy939-9LR6j5fPD02K-jDqSFiGiw_qkJEXNZA6ClnktOacJSfKECwZFTXIuoMyTLG5YGQsuBUszIRitJcg0SWfo4t-3c_arBx-qVvkGtOYGbO8rxpK0yDM6gOcj2NctiGo4uOVuW40PTP8A3zN17Q</recordid><startdate>199504</startdate><enddate>199504</enddate><creator>Dimitrijević, M</creator><creator>Marković, B M</creator><creator>Laban, O</creator><creator>Janković, B D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199504</creationdate><title>Suppression of experimental allergic encephalomyelitis in offspring of DA and Wistar rats following immunization of mother with encephalitogen</title><author>Dimitrijević, M ; Marković, B M ; Laban, O ; Janković, B D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p138t-55371918b7f6ed596bfaa521262ad7e8b16ade96240c790dafd734dd75bfef323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Antibodies, Anti-Idiotypic - blood</topic><topic>Disease Susceptibility - immunology</topic><topic>Drug Administration Schedule</topic><topic>Encephalomyelitis, Autoimmune, Experimental - immunology</topic><topic>Encephalomyelitis, Autoimmune, Experimental - prevention & control</topic><topic>Female</topic><topic>Immunity, Innate - immunology</topic><topic>Immunity, Maternally-Acquired</topic><topic>Immunization Schedule</topic><topic>Lactation - immunology</topic><topic>Male</topic><topic>Myelin Basic Protein - administration & dosage</topic><topic>Myelin Basic Protein - immunology</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Rats, Wistar</topic><topic>Species Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dimitrijević, M</creatorcontrib><creatorcontrib>Marković, B M</creatorcontrib><creatorcontrib>Laban, O</creatorcontrib><creatorcontrib>Janković, B D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dimitrijević, M</au><au>Marković, B M</au><au>Laban, O</au><au>Janković, B D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppression of experimental allergic encephalomyelitis in offspring of DA and Wistar rats following immunization of mother with encephalitogen</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>1995-04</date><risdate>1995</risdate><volume>58</volume><issue>1</issue><spage>43</spage><epage>50</epage><pages>43-50</pages><issn>0165-5728</issn><abstract>Immunization of female rats with encephalitogen before gestation, during gestation, and during lactation differentially decreased susceptibility to experimental allergic encephalomyelitis (EAE) in their offspring. The most pronounced suppression, revealed by lowered incidence and weaker clinical signs of the disease, was observed in offspring of mothers immunized before gestation and during lactation in both Dark August (EAE-susceptible), and Wistar (EAE-relatively resistant) rat strains. Induction of EAE in mothers during pregnancy only delayed the onset of the disease in DA progeny. The overall effect on EAE in offspring did not depend on the disease intensity in mothers. Our results suggest that anti-myelin basic protein (MBP) antibodies passively transferred from mothers are not responsible for the observed protection in offspring.</abstract><cop>Netherlands</cop><pmid>7537279</pmid><doi>10.1016/0165-5728(94)00186-R</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-5728 |
| ispartof | Journal of neuroimmunology, 1995-04, Vol.58 (1), p.43-50 |
| issn | 0165-5728 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77238645 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Antibodies, Anti-Idiotypic - blood Disease Susceptibility - immunology Drug Administration Schedule Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - prevention & control Female Immunity, Innate - immunology Immunity, Maternally-Acquired Immunization Schedule Lactation - immunology Male Myelin Basic Protein - administration & dosage Myelin Basic Protein - immunology Pregnancy Rats Rats, Inbred Strains Rats, Wistar Species Specificity |
| title | Suppression of experimental allergic encephalomyelitis in offspring of DA and Wistar rats following immunization of mother with encephalitogen |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T19%3A37%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Suppression%20of%20experimental%20allergic%20encephalomyelitis%20in%20offspring%20of%20DA%20and%20Wistar%20rats%20following%20immunization%20of%20mother%20with%20encephalitogen&rft.jtitle=Journal%20of%20neuroimmunology&rft.au=Dimitrijevi%C4%87,%20M&rft.date=1995-04&rft.volume=58&rft.issue=1&rft.spage=43&rft.epage=50&rft.pages=43-50&rft.issn=0165-5728&rft_id=info:doi/10.1016/0165-5728(94)00186-R&rft_dat=%3Cproquest_pubme%3E77238645%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77238645&rft_id=info:pmid/7537279&rfr_iscdi=true |