Rheumatoid Arthritis with Pleural Effusion Includes a Subgroup with Autoimmune Features and HLA-B8, Dw3 Association
Twenty-eight patients with rheumatoid pleural effusion were investigated to examine the frequency of HLA antigens as compared with 56 rheumatoid arthritis (RA) patients without this intrathoracic manifestation of RA and with 283 healthy controls. HLA-B8 was strongly associated with the presence of p...
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| Veröffentlicht in: | Scandinavian journal of rheumatology 1986, Vol.15 (3), p.290-296 |
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| container_title | Scandinavian journal of rheumatology |
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| creator | Hakala, Markku Tiilikainen, Anja Hämeenkorpi, Risto Ilonen, Jorma Jalava, Seppo Ruuska, Pekka Mäkitalo, Reino |
| description | Twenty-eight patients with rheumatoid pleural effusion were investigated to examine the frequency of HLA antigens as compared with 56 rheumatoid arthritis (RA) patients without this intrathoracic manifestation of RA and with 283 healthy controls. HLA-B8 was strongly associated with the presence of pleural effusion (PE) in RA patients. A high prevalence (71%) of B8/Dw3 was found among male RA patients of the PE group in whom the joint disease had begun at an age over 50 years and who also had besides pleuritis other intrathoracic manifestations of RA associated with high rheumatoid factor litres and low complement (C4) levels in sera. Actually, the HLA-B8 association was not seen in the rest of the PE group. The finding may be related to the heterogeneity of RA, a male subgroup of the disease being characterized by multiple intrathoracic manifestations and genetically associated with the large group of autoimmune disorders, such as SLE, characterized by high prevalences of HLA-B8 and D(R)3. |
| doi_str_mv | 10.3109/03009748609092595 |
| format | Article |
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HLA-B8 was strongly associated with the presence of pleural effusion (PE) in RA patients. A high prevalence (71%) of B8/Dw3 was found among male RA patients of the PE group in whom the joint disease had begun at an age over 50 years and who also had besides pleuritis other intrathoracic manifestations of RA associated with high rheumatoid factor litres and low complement (C4) levels in sera. Actually, the HLA-B8 association was not seen in the rest of the PE group. The finding may be related to the heterogeneity of RA, a male subgroup of the disease being characterized by multiple intrathoracic manifestations and genetically associated with the large group of autoimmune disorders, such as SLE, characterized by high prevalences of HLA-B8 and D(R)3.</description><identifier>ISSN: 0300-9742</identifier><identifier>EISSN: 1502-7732</identifier><identifier>DOI: 10.3109/03009748609092595</identifier><identifier>PMID: 3492039</identifier><identifier>CODEN: SJRHAT</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Adult ; Aged ; Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - immunology ; Autoimmune Diseases - complications ; Biological and medical sciences ; Complement System Proteins - analysis ; Diseases of the osteoarticular system ; HLA Antigens - analysis ; HLA-B8 Antigen ; HLA-D Antigens - analysis ; HLA-DR Antigens - analysis ; HLA-DR3 Antigen ; Humans ; Inflammatory joint diseases ; Male ; Medical sciences ; Middle Aged ; Pleural Effusion - complications</subject><ispartof>Scandinavian journal of rheumatology, 1986, Vol.15 (3), p.290-296</ispartof><rights>1986 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-3c6c3b46802d907232dd4653403d1a6dff51de8544b7edefd89dbeeb154da88f3</citedby><cites>FETCH-LOGICAL-c430t-3c6c3b46802d907232dd4653403d1a6dff51de8544b7edefd89dbeeb154da88f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/03009748609092595$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/03009748609092595$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4010,27902,27903,27904,59623,59729,60412,60518,61197,61232,61378,61413</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8032446$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3492039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hakala, Markku</creatorcontrib><creatorcontrib>Tiilikainen, Anja</creatorcontrib><creatorcontrib>Hämeenkorpi, Risto</creatorcontrib><creatorcontrib>Ilonen, Jorma</creatorcontrib><creatorcontrib>Jalava, Seppo</creatorcontrib><creatorcontrib>Ruuska, Pekka</creatorcontrib><creatorcontrib>Mäkitalo, Reino</creatorcontrib><title>Rheumatoid Arthritis with Pleural Effusion Includes a Subgroup with Autoimmune Features and HLA-B8, Dw3 Association</title><title>Scandinavian journal of rheumatology</title><addtitle>Scand J Rheumatol</addtitle><description>Twenty-eight patients with rheumatoid pleural effusion were investigated to examine the frequency of HLA antigens as compared with 56 rheumatoid arthritis (RA) patients without this intrathoracic manifestation of RA and with 283 healthy controls. HLA-B8 was strongly associated with the presence of pleural effusion (PE) in RA patients. A high prevalence (71%) of B8/Dw3 was found among male RA patients of the PE group in whom the joint disease had begun at an age over 50 years and who also had besides pleuritis other intrathoracic manifestations of RA associated with high rheumatoid factor litres and low complement (C4) levels in sera. Actually, the HLA-B8 association was not seen in the rest of the PE group. The finding may be related to the heterogeneity of RA, a male subgroup of the disease being characterized by multiple intrathoracic manifestations and genetically associated with the large group of autoimmune disorders, such as SLE, characterized by high prevalences of HLA-B8 and D(R)3.</description><subject>Adult</subject><subject>Aged</subject><subject>Arthritis, Rheumatoid - complications</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Autoimmune Diseases - complications</subject><subject>Biological and medical sciences</subject><subject>Complement System Proteins - analysis</subject><subject>Diseases of the osteoarticular system</subject><subject>HLA Antigens - analysis</subject><subject>HLA-B8 Antigen</subject><subject>HLA-D Antigens - analysis</subject><subject>HLA-DR Antigens - analysis</subject><subject>HLA-DR3 Antigen</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pleural Effusion - complications</subject><issn>0300-9742</issn><issn>1502-7732</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1rFDEchoModVv9AzwIOYgnx_4myXwEvYy1tYUFS9XzkMmHk5KZbPPB0v--s-xakEJPObzP8yZ5EXpXwmdaAj8FCsAb1tbAgZOKVy_QqqyAFE1DyUu02uXFApDX6DjGWwBgvOFH6IgyToDyFYo3o86TSN4q3IU0BptsxFubRnztdA7C4XNjcrR-xlezdFnpiAX-lYe_wefNnuzy4k9TnjW-0CLlsGNmhS_XXfGt_YS_bynuYvTSirQUvUGvjHBRvz2cJ-jPxfnvs8ti_fPH1Vm3LiSjkAoqa0kHVrdAFIeGUKIUqyvKgKpS1MqYqlS6rRgbGq20US1Xg9ZDWTEl2tbQE_Rx37sJ_i7rmPrJRqmdE7P2OfbN0skaqBew3IMy-BiDNv0m2EmE-76Efjd0_2ToxXl_KM_DpNWjcVh2yT8cchGlcCaIWdr4iLVACWO7q7_uMTsbHyax9cGpPol758M_hz73ii__6aMWLo1SBN3f-hzmZd5n_vAAW4SrKw</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>Hakala, Markku</creator><creator>Tiilikainen, Anja</creator><creator>Hämeenkorpi, Risto</creator><creator>Ilonen, Jorma</creator><creator>Jalava, Seppo</creator><creator>Ruuska, Pekka</creator><creator>Mäkitalo, Reino</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1986</creationdate><title>Rheumatoid Arthritis with Pleural Effusion Includes a Subgroup with Autoimmune Features and HLA-B8, Dw3 Association</title><author>Hakala, Markku ; Tiilikainen, Anja ; Hämeenkorpi, Risto ; Ilonen, Jorma ; Jalava, Seppo ; Ruuska, Pekka ; Mäkitalo, Reino</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-3c6c3b46802d907232dd4653403d1a6dff51de8544b7edefd89dbeeb154da88f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Arthritis, Rheumatoid - complications</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Autoimmune Diseases - complications</topic><topic>Biological and medical sciences</topic><topic>Complement System Proteins - analysis</topic><topic>Diseases of the osteoarticular system</topic><topic>HLA Antigens - analysis</topic><topic>HLA-B8 Antigen</topic><topic>HLA-D Antigens - analysis</topic><topic>HLA-DR Antigens - analysis</topic><topic>HLA-DR3 Antigen</topic><topic>Humans</topic><topic>Inflammatory joint diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pleural Effusion - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hakala, Markku</creatorcontrib><creatorcontrib>Tiilikainen, Anja</creatorcontrib><creatorcontrib>Hämeenkorpi, Risto</creatorcontrib><creatorcontrib>Ilonen, Jorma</creatorcontrib><creatorcontrib>Jalava, Seppo</creatorcontrib><creatorcontrib>Ruuska, Pekka</creatorcontrib><creatorcontrib>Mäkitalo, Reino</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hakala, Markku</au><au>Tiilikainen, Anja</au><au>Hämeenkorpi, Risto</au><au>Ilonen, Jorma</au><au>Jalava, Seppo</au><au>Ruuska, Pekka</au><au>Mäkitalo, Reino</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rheumatoid Arthritis with Pleural Effusion Includes a Subgroup with Autoimmune Features and HLA-B8, Dw3 Association</atitle><jtitle>Scandinavian journal of rheumatology</jtitle><addtitle>Scand J Rheumatol</addtitle><date>1986</date><risdate>1986</risdate><volume>15</volume><issue>3</issue><spage>290</spage><epage>296</epage><pages>290-296</pages><issn>0300-9742</issn><eissn>1502-7732</eissn><coden>SJRHAT</coden><abstract>Twenty-eight patients with rheumatoid pleural effusion were investigated to examine the frequency of HLA antigens as compared with 56 rheumatoid arthritis (RA) patients without this intrathoracic manifestation of RA and with 283 healthy controls. HLA-B8 was strongly associated with the presence of pleural effusion (PE) in RA patients. A high prevalence (71%) of B8/Dw3 was found among male RA patients of the PE group in whom the joint disease had begun at an age over 50 years and who also had besides pleuritis other intrathoracic manifestations of RA associated with high rheumatoid factor litres and low complement (C4) levels in sera. Actually, the HLA-B8 association was not seen in the rest of the PE group. The finding may be related to the heterogeneity of RA, a male subgroup of the disease being characterized by multiple intrathoracic manifestations and genetically associated with the large group of autoimmune disorders, such as SLE, characterized by high prevalences of HLA-B8 and D(R)3.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><pmid>3492039</pmid><doi>10.3109/03009748609092595</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-9742 |
| ispartof | Scandinavian journal of rheumatology, 1986, Vol.15 (3), p.290-296 |
| issn | 0300-9742 1502-7732 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adult Aged Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - immunology Autoimmune Diseases - complications Biological and medical sciences Complement System Proteins - analysis Diseases of the osteoarticular system HLA Antigens - analysis HLA-B8 Antigen HLA-D Antigens - analysis HLA-DR Antigens - analysis HLA-DR3 Antigen Humans Inflammatory joint diseases Male Medical sciences Middle Aged Pleural Effusion - complications |
| title | Rheumatoid Arthritis with Pleural Effusion Includes a Subgroup with Autoimmune Features and HLA-B8, Dw3 Association |
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