Age related changes in platelet lipid composition
Platelet lipid composition was investigated in 52 healthy subjects aged 20 to 68 years with similar dietary habits and living in a narrow geographic area in order to search possible changes referrable to aging. No significant variations were observed when platelet cholesterol, total phospholipids an...
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| Veröffentlicht in: | Thrombosis research 1986-11, Vol.44 (4), p.427-437 |
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| container_end_page | 437 |
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| container_issue | 4 |
| container_start_page | 427 |
| container_title | Thrombosis research |
| container_volume | 44 |
| creator | Prisco, Domenico Rogasi, Pier Giorgio Matucci, Marzia Paniccia, Rita Abbate, Rosanna Gensini, Gian Franco Gian Gastone Neri, Serneri |
| description | Platelet lipid composition was investigated in 52 healthy subjects aged 20 to 68 years with similar dietary habits and living in a narrow geographic area in order to search possible changes referrable to aging. No significant variations were observed when platelet cholesterol, total phospholipids and different phospholipid fractions were considered, whereas cholesterol/ phospholipid (C/PL) molar ratio significantly increased with aging (p |
| doi_str_mv | 10.1016/0049-3848(86)90321-X |
| format | Article |
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No significant variations were observed when platelet cholesterol, total phospholipids and different phospholipid fractions were considered, whereas cholesterol/ phospholipid (C/PL) molar ratio significantly increased with aging (p<O.01). Moreover, a significant increase in 16:0 + 16:1 fatty acids was found in phosphatidylcholine (PC) and in sphingomyelin (SP) (r= 0.62 , p<O.001 and r=0.30, p<0.05 respectively) and a decrease in 18:2 n6 in the phospholipid fractions considered (at least p<0.05). These results indicate that modifications in platelet lipid composition occur with aging and that they could affect platelet functions so playing a role in the onset of atherosclerosis and in thrombotic phenomena occurring with increasing frequency in the elderly.</description><identifier>ISSN: 0049-3848</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/0049-3848(86)90321-X</identifier><identifier>PMID: 3798408</identifier><identifier>CODEN: THBRAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Ltd</publisher><subject>Adult ; Aged ; Aging ; Biological and medical sciences ; Blood coagulation. Blood cells ; Blood Platelets - analysis ; Cholesterol - blood ; Cholesterol, HDL - blood ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; linoleic acid ; Lipids - blood ; Male ; Middle Aged ; Molecular and cellular biology ; phospholipids ; Phospholipids - blood ; Platelet ; platelet lipids ; polyunsaturated fatty acids ; Reference Values ; Smoking ; Triglycerides - blood</subject><ispartof>Thrombosis research, 1986-11, Vol.44 (4), p.427-437</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-3087099247e9680d940878220168e3d5676e39d81185884fb8eaf02f998531c63</citedby><cites>FETCH-LOGICAL-c386t-3087099247e9680d940878220168e3d5676e39d81185884fb8eaf02f998531c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0049-3848(86)90321-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8266975$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3798408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prisco, Domenico</creatorcontrib><creatorcontrib>Rogasi, Pier Giorgio</creatorcontrib><creatorcontrib>Matucci, Marzia</creatorcontrib><creatorcontrib>Paniccia, Rita</creatorcontrib><creatorcontrib>Abbate, Rosanna</creatorcontrib><creatorcontrib>Gensini, Gian Franco</creatorcontrib><creatorcontrib>Gian Gastone Neri, Serneri</creatorcontrib><title>Age related changes in platelet lipid composition</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description>Platelet lipid composition was investigated in 52 healthy subjects aged 20 to 68 years with similar dietary habits and living in a narrow geographic area in order to search possible changes referrable to aging. No significant variations were observed when platelet cholesterol, total phospholipids and different phospholipid fractions were considered, whereas cholesterol/ phospholipid (C/PL) molar ratio significantly increased with aging (p<O.01). Moreover, a significant increase in 16:0 + 16:1 fatty acids was found in phosphatidylcholine (PC) and in sphingomyelin (SP) (r= 0.62 , p<O.001 and r=0.30, p<0.05 respectively) and a decrease in 18:2 n6 in the phospholipid fractions considered (at least p<0.05). These results indicate that modifications in platelet lipid composition occur with aging and that they could affect platelet functions so playing a role in the onset of atherosclerosis and in thrombotic phenomena occurring with increasing frequency in the elderly.</description><subject>Adult</subject><subject>Aged</subject><subject>Aging</subject><subject>Biological and medical sciences</subject><subject>Blood coagulation. Blood cells</subject><subject>Blood Platelets - analysis</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>linoleic acid</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular and cellular biology</subject><subject>phospholipids</subject><subject>Phospholipids - blood</subject><subject>Platelet</subject><subject>platelet lipids</subject><subject>polyunsaturated fatty acids</subject><subject>Reference Values</subject><subject>Smoking</subject><subject>Triglycerides - blood</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMouq7-A4UeRPRQzUebTC7CsvgFC14UvIWYTjXSbWvSFfz3pu6yR0-BeZ-ZvDyEnDB6xSiT15QWOhdQwAXIS00FZ_nrDpkwUDrnheK7ZLJFDshhjJ-UMsV0uU_2hdJQUJgQNnvHLGBjB6wy92Hbd4yZb7N-nDQ4ZI3vfUq6Zd9FP_iuPSJ7tW0iHm_eKXm5u32eP-SLp_vH-WyROwFyyAUFRbVORVBLoJVO3yngPDUHFFUplUShK2AMSoCifgO0NeW11lAK5qSYkvP13T50XyuMg1n66LBpbIvdKhqluOCS8wQWa9CFLsaAtemDX9rwYxg1oykzajCjBgPS_Jkyr2ntdHN_9bbEaru0UZPys01uo7NNHWzrfNxiwKXUqkzYzRrD5OLbYzDReWwdVj6gG0zV-f97_AK68oHJ</recordid><startdate>19861115</startdate><enddate>19861115</enddate><creator>Prisco, Domenico</creator><creator>Rogasi, Pier Giorgio</creator><creator>Matucci, Marzia</creator><creator>Paniccia, Rita</creator><creator>Abbate, Rosanna</creator><creator>Gensini, Gian Franco</creator><creator>Gian Gastone Neri, Serneri</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19861115</creationdate><title>Age related changes in platelet lipid composition</title><author>Prisco, Domenico ; Rogasi, Pier Giorgio ; Matucci, Marzia ; Paniccia, Rita ; Abbate, Rosanna ; Gensini, Gian Franco ; Gian Gastone Neri, Serneri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-3087099247e9680d940878220168e3d5676e39d81185884fb8eaf02f998531c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aging</topic><topic>Biological and medical sciences</topic><topic>Blood coagulation. Blood cells</topic><topic>Blood Platelets - analysis</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>linoleic acid</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular and cellular biology</topic><topic>phospholipids</topic><topic>Phospholipids - blood</topic><topic>Platelet</topic><topic>platelet lipids</topic><topic>polyunsaturated fatty acids</topic><topic>Reference Values</topic><topic>Smoking</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prisco, Domenico</creatorcontrib><creatorcontrib>Rogasi, Pier Giorgio</creatorcontrib><creatorcontrib>Matucci, Marzia</creatorcontrib><creatorcontrib>Paniccia, Rita</creatorcontrib><creatorcontrib>Abbate, Rosanna</creatorcontrib><creatorcontrib>Gensini, Gian Franco</creatorcontrib><creatorcontrib>Gian Gastone Neri, Serneri</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prisco, Domenico</au><au>Rogasi, Pier Giorgio</au><au>Matucci, Marzia</au><au>Paniccia, Rita</au><au>Abbate, Rosanna</au><au>Gensini, Gian Franco</au><au>Gian Gastone Neri, Serneri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age related changes in platelet lipid composition</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>1986-11-15</date><risdate>1986</risdate><volume>44</volume><issue>4</issue><spage>427</spage><epage>437</epage><pages>427-437</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><coden>THBRAA</coden><abstract>Platelet lipid composition was investigated in 52 healthy subjects aged 20 to 68 years with similar dietary habits and living in a narrow geographic area in order to search possible changes referrable to aging. No significant variations were observed when platelet cholesterol, total phospholipids and different phospholipid fractions were considered, whereas cholesterol/ phospholipid (C/PL) molar ratio significantly increased with aging (p<O.01). Moreover, a significant increase in 16:0 + 16:1 fatty acids was found in phosphatidylcholine (PC) and in sphingomyelin (SP) (r= 0.62 , p<O.001 and r=0.30, p<0.05 respectively) and a decrease in 18:2 n6 in the phospholipid fractions considered (at least p<0.05). These results indicate that modifications in platelet lipid composition occur with aging and that they could affect platelet functions so playing a role in the onset of atherosclerosis and in thrombotic phenomena occurring with increasing frequency in the elderly.</abstract><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>3798408</pmid><doi>10.1016/0049-3848(86)90321-X</doi><tpages>11</tpages></addata></record> |
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| identifier | ISSN: 0049-3848 |
| ispartof | Thrombosis research, 1986-11, Vol.44 (4), p.427-437 |
| issn | 0049-3848 1879-2472 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Aged Aging Biological and medical sciences Blood coagulation. Blood cells Blood Platelets - analysis Cholesterol - blood Cholesterol, HDL - blood Female Fundamental and applied biological sciences. Psychology Humans linoleic acid Lipids - blood Male Middle Aged Molecular and cellular biology phospholipids Phospholipids - blood Platelet platelet lipids polyunsaturated fatty acids Reference Values Smoking Triglycerides - blood |
| title | Age related changes in platelet lipid composition |
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