Vascular smooth muscle cell heme oxygenases generate guanylyl cyclase-stimulatory carbon monoxide

Carbon monoxide (CO), like nitric oxide (NO), stimulates soluble guanylyl cyclase and thereby raises intracellular levels of cGMP. We examined the endogenous capacity of vascular smooth muscle cells (SMCs) to produce CO from heme through the activity of heme oxygenases. Cultured SMCs from rat aorta...

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