The effects of doxapram on breathing, heart rate and blood pressure in fetal lambs
In experiments to assess its value in the study of fetal arterial chemoreceptor reflexes, doxapram (0.5 – 2mg i.a.) given to unanaesthetized fetal lambs in utero in low voltage electrocortical activity stimulated fetal breathing in 73% of trials. The response began within a few seconds and lasted up...
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Veröffentlicht in: | Respiration physiology 1986-12, Vol.66 (3), p.387-396 |
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description | In experiments to assess its value in the study of fetal arterial chemoreceptor reflexes, doxapram (0.5 – 2mg i.a.) given to unanaesthetized fetal lambs in utero in low voltage electrocortical activity stimulated fetal breathing in 73% of trials. The response began within a few seconds and lasted up to 5 min.
This response to doxapram was present in intact or mid-collicular brainstem transected fetuses and after bilateral section of the carotid sinus nerves and cervical vagosympathetic trunks (denervation).
In intact and brainstem transected fetuses, doxapram injections were followed by a modest rise in arterial pressure and a small fall in heart rate. After denervation the rise in arterial pressure was fourfold and the heart rate increased. Electrocortical activity and limb movements were not affected in any group of lambs, and fetal breathing was not induced during isocapnic hypoxia.
It is concluded that doxapram stimulates fetal breathing by a central action below the pons, and that it can therefore not be used to study peripheral arterial chemoreceptor function in utero. |
doi_str_mv | 10.1016/0034-5687(86)90088-5 |
format | Article |
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This response to doxapram was present in intact or mid-collicular brainstem transected fetuses and after bilateral section of the carotid sinus nerves and cervical vagosympathetic trunks (denervation).
In intact and brainstem transected fetuses, doxapram injections were followed by a modest rise in arterial pressure and a small fall in heart rate. After denervation the rise in arterial pressure was fourfold and the heart rate increased. Electrocortical activity and limb movements were not affected in any group of lambs, and fetal breathing was not induced during isocapnic hypoxia.
It is concluded that doxapram stimulates fetal breathing by a central action below the pons, and that it can therefore not be used to study peripheral arterial chemoreceptor function in utero.</description><identifier>ISSN: 0034-5687</identifier><identifier>DOI: 10.1016/0034-5687(86)90088-5</identifier><identifier>PMID: 3797850</identifier><identifier>CODEN: RSPYAK</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Animals ; Arterial chemoreceptor ; Biological and medical sciences ; Blood pressure ; Blood Pressure - drug effects ; Cardiovascular System - drug effects ; Cardiovascular System - embryology ; Carotid body ; Control of breathing ; Dose-Response Relationship, Drug ; Doxapram ; Doxapram - pharmacology ; Female ; Fetus ; Fetus - physiology ; Heart frequency ; Heart Rate - drug effects ; Medical sciences ; Pharmacology. Drug treatments ; Pregnancy ; Respiration - drug effects ; Respiratory centers ; Respiratory system ; Sheep</subject><ispartof>Respiration physiology, 1986-12, Vol.66 (3), p.387-396</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-fa1734a00b35a01ca589d9d2aa1e436f0d8ab8801e0e30b844aa5a3d48b041753</citedby><cites>FETCH-LOGICAL-c386t-fa1734a00b35a01ca589d9d2aa1e436f0d8ab8801e0e30b844aa5a3d48b041753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8072790$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3797850$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bamford, O.S.</creatorcontrib><creatorcontrib>Dawes, G.S.</creatorcontrib><creatorcontrib>Hanson, M.A.</creatorcontrib><creatorcontrib>Ward, R.A.</creatorcontrib><title>The effects of doxapram on breathing, heart rate and blood pressure in fetal lambs</title><title>Respiration physiology</title><addtitle>Respir Physiol</addtitle><description>In experiments to assess its value in the study of fetal arterial chemoreceptor reflexes, doxapram (0.5 – 2mg i.a.) given to unanaesthetized fetal lambs in utero in low voltage electrocortical activity stimulated fetal breathing in 73% of trials. The response began within a few seconds and lasted up to 5 min.
This response to doxapram was present in intact or mid-collicular brainstem transected fetuses and after bilateral section of the carotid sinus nerves and cervical vagosympathetic trunks (denervation).
In intact and brainstem transected fetuses, doxapram injections were followed by a modest rise in arterial pressure and a small fall in heart rate. After denervation the rise in arterial pressure was fourfold and the heart rate increased. Electrocortical activity and limb movements were not affected in any group of lambs, and fetal breathing was not induced during isocapnic hypoxia.
It is concluded that doxapram stimulates fetal breathing by a central action below the pons, and that it can therefore not be used to study peripheral arterial chemoreceptor function in utero.</description><subject>Animals</subject><subject>Arterial chemoreceptor</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiovascular System - drug effects</subject><subject>Cardiovascular System - embryology</subject><subject>Carotid body</subject><subject>Control of breathing</subject><subject>Dose-Response Relationship, Drug</subject><subject>Doxapram</subject><subject>Doxapram - pharmacology</subject><subject>Female</subject><subject>Fetus</subject><subject>Fetus - physiology</subject><subject>Heart frequency</subject><subject>Heart Rate - drug effects</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Pregnancy</subject><subject>Respiration - drug effects</subject><subject>Respiratory centers</subject><subject>Respiratory system</subject><subject>Sheep</subject><issn>0034-5687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhnVoSdM0_6AFHUppIE5HK1uSL4US8gWBQEnOYiyNuiq2tZW8Jfn3tbvLHnMaZuaZl-Fh7KOACwFCfQOQddUoo78addYCGFM1b9jxYfyOvS_lN8y9AnXEjqRutWngmP18XBOnEMhNhafAfXrGTcaBp5F3mXBax_HXOV8T5olnnIjj6HnXp-T5JlMp20w8jjzQhD3vcejKB_Y2YF_odF9P2NP11ePlbXX_cHN3-eO-ctKoqQootKwRoJMNgnDYmNa3foUoqJYqgDfYGQOCgCR0pq4RG5S-Nh3UQjfyhH3Z5W5y-rOlMtkhFkd9jyOlbbFar6QwUs1gvQNdTqVkCnaT44D5xQqwiz67eLKLJ2uU_a_PLvmf9vnbbiB_ONq7m_ef93ssDvuQcXSxHDADeqXbBfu-w2h28TdStsVFGh35mGfr1qf4-h__AMsXjNE</recordid><startdate>19861201</startdate><enddate>19861201</enddate><creator>Bamford, O.S.</creator><creator>Dawes, G.S.</creator><creator>Hanson, M.A.</creator><creator>Ward, R.A.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19861201</creationdate><title>The effects of doxapram on breathing, heart rate and blood pressure in fetal lambs</title><author>Bamford, O.S. ; Dawes, G.S. ; Hanson, M.A. ; Ward, R.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-fa1734a00b35a01ca589d9d2aa1e436f0d8ab8801e0e30b844aa5a3d48b041753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Arterial chemoreceptor</topic><topic>Biological and medical sciences</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiovascular System - drug effects</topic><topic>Cardiovascular System - embryology</topic><topic>Carotid body</topic><topic>Control of breathing</topic><topic>Dose-Response Relationship, Drug</topic><topic>Doxapram</topic><topic>Doxapram - pharmacology</topic><topic>Female</topic><topic>Fetus</topic><topic>Fetus - physiology</topic><topic>Heart frequency</topic><topic>Heart Rate - drug effects</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Pregnancy</topic><topic>Respiration - drug effects</topic><topic>Respiratory centers</topic><topic>Respiratory system</topic><topic>Sheep</topic><toplevel>online_resources</toplevel><creatorcontrib>Bamford, O.S.</creatorcontrib><creatorcontrib>Dawes, G.S.</creatorcontrib><creatorcontrib>Hanson, M.A.</creatorcontrib><creatorcontrib>Ward, R.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiration physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bamford, O.S.</au><au>Dawes, G.S.</au><au>Hanson, M.A.</au><au>Ward, R.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of doxapram on breathing, heart rate and blood pressure in fetal lambs</atitle><jtitle>Respiration physiology</jtitle><addtitle>Respir Physiol</addtitle><date>1986-12-01</date><risdate>1986</risdate><volume>66</volume><issue>3</issue><spage>387</spage><epage>396</epage><pages>387-396</pages><issn>0034-5687</issn><coden>RSPYAK</coden><abstract>In experiments to assess its value in the study of fetal arterial chemoreceptor reflexes, doxapram (0.5 – 2mg i.a.) given to unanaesthetized fetal lambs in utero in low voltage electrocortical activity stimulated fetal breathing in 73% of trials. The response began within a few seconds and lasted up to 5 min.
This response to doxapram was present in intact or mid-collicular brainstem transected fetuses and after bilateral section of the carotid sinus nerves and cervical vagosympathetic trunks (denervation).
In intact and brainstem transected fetuses, doxapram injections were followed by a modest rise in arterial pressure and a small fall in heart rate. After denervation the rise in arterial pressure was fourfold and the heart rate increased. Electrocortical activity and limb movements were not affected in any group of lambs, and fetal breathing was not induced during isocapnic hypoxia.
It is concluded that doxapram stimulates fetal breathing by a central action below the pons, and that it can therefore not be used to study peripheral arterial chemoreceptor function in utero.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>3797850</pmid><doi>10.1016/0034-5687(86)90088-5</doi><tpages>10</tpages></addata></record> |
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subjects | Animals Arterial chemoreceptor Biological and medical sciences Blood pressure Blood Pressure - drug effects Cardiovascular System - drug effects Cardiovascular System - embryology Carotid body Control of breathing Dose-Response Relationship, Drug Doxapram Doxapram - pharmacology Female Fetus Fetus - physiology Heart frequency Heart Rate - drug effects Medical sciences Pharmacology. Drug treatments Pregnancy Respiration - drug effects Respiratory centers Respiratory system Sheep |
title | The effects of doxapram on breathing, heart rate and blood pressure in fetal lambs |
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