A paradoxical effect of antibody concentration on VWF-dependent platelet agglutination distinguishes between botrocetin and ristocetin-induced agglutination

Several heterologous antisera directed against either human or porcine von Willebrand factor (vWF), inhibited botrocetin-induced vWF-dependent agglutination at high concentrations but were found to enhance this reaction at low concentrations. Purified IgG from these immune sera also potentiated botr...

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Veröffentlicht in:	Thrombosis research 1986-12, Vol.44 (6), p.749-760
Hauptverfasser:	Roberson, David W., Upchurch, G.R., Lamb, Mary Ann, Read, Marjorie S., Wagner, Robert H., Cooper, Herbert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Animals antibodies Antibodies - pharmacology Antibody Specificity Biological and medical sciences Blood coagulation. Blood cells Coagulation factors Crotalid Venoms - pharmacology Fundamental and applied biological sciences. Psychology Humans Immune Sera - analysis Immunoglobulin Fab Fragments - pharmacology Molecular and cellular biology Platelet Aggregation - drug effects Platelets Protein Conformation Rabbits Ristocetin - pharmacology ristocetin botrocetin Swine von Willebrand factor von Willebrand Factor - immunology von Willebrand Factor - physiology
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