Measurement of colony-stimulating factors in synovial fluid : potential clinical value
In this study, 100 synovial fluid (SF) samples from patients with a variety of arthritides were assayed for levels of colony-stimulating factors (CSFs) using a human bone-marrow bioassay and enzyme immunoassays for granulocyte (G-) and granulocyte-macrophage (GM-) CSFs. GM-CSF was found more frequen...
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| Veröffentlicht in: | Rheumatology international 1995, Vol.14 (5), p.177-182 |
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| container_title | Rheumatology international |
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| creator | BELL, A. L MAGILL, M. K MCKANE, W. R KIRK, F IRVINE, A. E |
| description | In this study, 100 synovial fluid (SF) samples from patients with a variety of arthritides were assayed for levels of colony-stimulating factors (CSFs) using a human bone-marrow bioassay and enzyme immunoassays for granulocyte (G-) and granulocyte-macrophage (GM-) CSFs. GM-CSF was found more frequently in samples from rheumatoid arthritis (RA) subjects (49%) than in non-RA samples (29%). Absence of GM- but not G- or bioassay CSFs characterised samples from subjects with psoriatic arthritis and ankylosing spondylitis (n = 14). There was strong evidence of an antagonistic relationship between levels of G- and GM-CSFs in samples from RA patients, an effect independent of drug treatment. However, treatment with non-steroidal anti-inflammatory agents (NSAIDs) may affect reported CSF concentrations: G-CSF levels were significantly lower in samples from subjects not taking NSAIDs. These results suggest that SF-CSF estimations using commercially available assays could provide useful diagnostic clues for clinicians, but careful interpretation is warranted particularly in patients on long-term NSAID treatment. |
| doi_str_mv | 10.1007/BF00262295 |
| format | Article |
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However, treatment with non-steroidal anti-inflammatory agents (NSAIDs) may affect reported CSF concentrations: G-CSF levels were significantly lower in samples from subjects not taking NSAIDs. 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There was strong evidence of an antagonistic relationship between levels of G- and GM-CSFs in samples from RA patients, an effect independent of drug treatment. However, treatment with non-steroidal anti-inflammatory agents (NSAIDs) may affect reported CSF concentrations: G-CSF levels were significantly lower in samples from subjects not taking NSAIDs. These results suggest that SF-CSF estimations using commercially available assays could provide useful diagnostic clues for clinicians, but careful interpretation is warranted particularly in patients on long-term NSAID treatment.</description><subject>Arthritis, Rheumatoid - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Diseases of the osteoarticular system</subject><subject>Granulocyte Colony-Stimulating Factor - analysis</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor - analysis</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Medical sciences</subject><subject>Synovial Fluid - metabolism</subject><issn>0172-8172</issn><issn>1437-160X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM9LwzAUx4Moc04v3oUexINQfUnaJvGmw6kw8aLirSRpIpG0mU072H9vx8q8vF_fz3vwvgidY7jBAOz2YQFACkJEfoCmOKMsxQV8HaIpYEZSPoRjdBLjDwx9UcAETVhOC5HTKfp8NTL2ralN0yXBJjr40GzS2Lm697JzzXdipe5CGxPXJHHThLWTPrG-d1Vyl6xCNyxuJ9q7xumhWEvfm1N0ZKWP5mzMM_SxeHyfP6fLt6eX-f0y1RTjLtWgMkE4zTTNgCmrCK2EYtaCKoTJtwK3QLHkQpJcZYXhomJKCZMB51bQGbra3V214bc3sStrF7XxXjYm9LFkjBAOwAfwegfqNsTYGluuWlfLdlNiKLcmlv8mDvDFeLVXtan26OjaoF-OuozDy7aVjXZxj1HKs4wC_QO-bHkx</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>BELL, A. 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| fulltext | fulltext |
| identifier | ISSN: 0172-8172 |
| ispartof | Rheumatology international, 1995, Vol.14 (5), p.177-182 |
| issn | 0172-8172 1437-160X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77228008 |
| source | MEDLINE; Springer Online Journals Complete |
| subjects | Arthritis, Rheumatoid - metabolism Biological and medical sciences Biomarkers Diseases of the osteoarticular system Granulocyte Colony-Stimulating Factor - analysis Granulocyte-Macrophage Colony-Stimulating Factor - analysis Humans Inflammatory joint diseases Medical sciences Synovial Fluid - metabolism |
| title | Measurement of colony-stimulating factors in synovial fluid : potential clinical value |
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