Multiple point mutations in an endogenous retroviral gene confer high immunogenicity on a drug-treated murine tumor

Exposure in vivo of murine L5178Y lymphoma cells to cytoreductive triazene derivatives leads to the generation of immunogenic variant lines expressing new transplantation Ags recognized by CTL. In one such clonal variant (clone D), at least one subset of T cell neoepitopes are provided by proteins p...

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