Different patterns of C3 and C4 activation in the varied types of juvenile arthritis
Quantitative assays for C3 and C4 activation were carried out simultaneously on blood from children with varied types of juvenile arthritis. Factor VIII-related antigen was also measured as an indicator of vascular damage. In active systemic juvenile arthritis, the C4d/C4 ratio was frequently elevat...
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| Veröffentlicht in: | Pediatric research 1986-12, Vol.20 (12), p.1332-1337 |
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| container_issue | 12 |
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| container_title | Pediatric research |
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| creator | MILLER, J. J OLDS, L. C SILVERMAN, E. D MILGROM, H CURD, J. G |
| description | Quantitative assays for C3 and C4 activation were carried out simultaneously on blood from children with varied types of juvenile arthritis. Factor VIII-related antigen was also measured as an indicator of vascular damage. In active systemic juvenile arthritis, the C4d/C4 ratio was frequently elevated and was usually associated with elevated C3d/C3 ratios and elevated concentrations of factor VIII-related antigen. Children with chronic polyarticular arthritis, no matter which forms of onset they had had, also had increased levels of the C4d/C4 ratio, C3d/C3 ratio, and factor VIII-related antigen, but these were less consistent and were not associated with each other. In contrast, in pauciarticular arthritis there was a uniquely isolated increase in the C3d/C3 ratio. This work implies that there are different mechanisms responsible for complement activation in the different types and at different stages of juvenile arthritis. |
| doi_str_mv | 10.1203/00006450-198612000-00030 |
| format | Article |
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This work implies that there are different mechanisms responsible for complement activation in the different types and at different stages of juvenile arthritis.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1203/00006450-198612000-00030</identifier><identifier>PMID: 3099253</identifier><identifier>CODEN: PEREBL</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Antigens - analysis ; Arthritis, Juvenile - immunology ; Autoantibodies - blood ; Biological and medical sciences ; Child ; Complement Activation ; Complement C3 - analysis ; Complement C3d ; Complement C4 - analysis ; Complement C4b ; Diseases of the osteoarticular system ; Factor VIII - analysis ; Factor VIII - immunology ; Female ; Humans ; Inflammatory joint diseases ; Male ; Medical sciences ; Peptide Fragments - analysis ; von Willebrand Factor</subject><ispartof>Pediatric research, 1986-12, Vol.20 (12), p.1332-1337</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3040-d1f10b5a48762ae5fd18b3494f477caecaa551e35b4fe6ec8e7c5c91896f6e403</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8103325$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3099253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MILLER, J. J</creatorcontrib><creatorcontrib>OLDS, L. C</creatorcontrib><creatorcontrib>SILVERMAN, E. D</creatorcontrib><creatorcontrib>MILGROM, H</creatorcontrib><creatorcontrib>CURD, J. G</creatorcontrib><title>Different patterns of C3 and C4 activation in the varied types of juvenile arthritis</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><description>Quantitative assays for C3 and C4 activation were carried out simultaneously on blood from children with varied types of juvenile arthritis. Factor VIII-related antigen was also measured as an indicator of vascular damage. In active systemic juvenile arthritis, the C4d/C4 ratio was frequently elevated and was usually associated with elevated C3d/C3 ratios and elevated concentrations of factor VIII-related antigen. Children with chronic polyarticular arthritis, no matter which forms of onset they had had, also had increased levels of the C4d/C4 ratio, C3d/C3 ratio, and factor VIII-related antigen, but these were less consistent and were not associated with each other. In contrast, in pauciarticular arthritis there was a uniquely isolated increase in the C3d/C3 ratio. This work implies that there are different mechanisms responsible for complement activation in the different types and at different stages of juvenile arthritis.</description><subject>Adolescent</subject><subject>Antigens - analysis</subject><subject>Arthritis, Juvenile - immunology</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Complement Activation</subject><subject>Complement C3 - analysis</subject><subject>Complement C3d</subject><subject>Complement C4 - analysis</subject><subject>Complement C4b</subject><subject>Diseases of the osteoarticular system</subject><subject>Factor VIII - analysis</subject><subject>Factor VIII - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Peptide Fragments - analysis</subject><subject>von Willebrand Factor</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtrwzAMgM3Y6LpuP2Hgw9gtmx3biXMc2RMKu3TnoDoydUmTznYL_fdzH6tBGEmfJPgIoZw98ZyJZ5ZeIRXLeKWLVGEsSyHYBRlzJVIiZXlJxqnEM1FV-prchLBkjEul5YiMBKuqXIkxmb06a9FjH-kaYkTfBzpYWgsKfUtrScFEt4Xohp66nsYF0i14hy2NuzUe2OVmi73rkIKPC--iC7fkykIX8O70T8jP-9us_sym3x9f9cs0M4JJlrXccjZXIHVZ5IDKtlzPhayklWVpAA2AUhyFmkuLBRqNpVGm4roqbIGSiQl5PO5d--F3gyE2KxcMdh30OGxCU5Z5nlbtQX0EjR9C8GibtXcr8LuGs2YvtPkX2pyFNgehafT-dGMzX2F7HjwZTP2HUx-Cgc566I0LZ0xzJkTi_gCMh3zd</recordid><startdate>198612</startdate><enddate>198612</enddate><creator>MILLER, J. 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G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3040-d1f10b5a48762ae5fd18b3494f477caecaa551e35b4fe6ec8e7c5c91896f6e403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adolescent</topic><topic>Antigens - analysis</topic><topic>Arthritis, Juvenile - immunology</topic><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Complement Activation</topic><topic>Complement C3 - analysis</topic><topic>Complement C3d</topic><topic>Complement C4 - analysis</topic><topic>Complement C4b</topic><topic>Diseases of the osteoarticular system</topic><topic>Factor VIII - analysis</topic><topic>Factor VIII - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammatory joint diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Peptide Fragments - analysis</topic><topic>von Willebrand Factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MILLER, J. J</creatorcontrib><creatorcontrib>OLDS, L. C</creatorcontrib><creatorcontrib>SILVERMAN, E. D</creatorcontrib><creatorcontrib>MILGROM, H</creatorcontrib><creatorcontrib>CURD, J. G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MILLER, J. J</au><au>OLDS, L. C</au><au>SILVERMAN, E. D</au><au>MILGROM, H</au><au>CURD, J. G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different patterns of C3 and C4 activation in the varied types of juvenile arthritis</atitle><jtitle>Pediatric research</jtitle><addtitle>Pediatr Res</addtitle><date>1986-12</date><risdate>1986</risdate><volume>20</volume><issue>12</issue><spage>1332</spage><epage>1337</epage><pages>1332-1337</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><coden>PEREBL</coden><abstract>Quantitative assays for C3 and C4 activation were carried out simultaneously on blood from children with varied types of juvenile arthritis. Factor VIII-related antigen was also measured as an indicator of vascular damage. In active systemic juvenile arthritis, the C4d/C4 ratio was frequently elevated and was usually associated with elevated C3d/C3 ratios and elevated concentrations of factor VIII-related antigen. Children with chronic polyarticular arthritis, no matter which forms of onset they had had, also had increased levels of the C4d/C4 ratio, C3d/C3 ratio, and factor VIII-related antigen, but these were less consistent and were not associated with each other. In contrast, in pauciarticular arthritis there was a uniquely isolated increase in the C3d/C3 ratio. This work implies that there are different mechanisms responsible for complement activation in the different types and at different stages of juvenile arthritis.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>3099253</pmid><doi>10.1203/00006450-198612000-00030</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-3998 |
| ispartof | Pediatric research, 1986-12, Vol.20 (12), p.1332-1337 |
| issn | 0031-3998 1530-0447 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Adolescent Antigens - analysis Arthritis, Juvenile - immunology Autoantibodies - blood Biological and medical sciences Child Complement Activation Complement C3 - analysis Complement C3d Complement C4 - analysis Complement C4b Diseases of the osteoarticular system Factor VIII - analysis Factor VIII - immunology Female Humans Inflammatory joint diseases Male Medical sciences Peptide Fragments - analysis von Willebrand Factor |
| title | Different patterns of C3 and C4 activation in the varied types of juvenile arthritis |
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