Full‐Length and Truncated Alzheimer Amyloid Precursors in Chromaffin Granules: Solubilization of Membrane Amyloid Precursor Is Mediated by an Enzymatic Mechanism

: The amyloid β peptide (Aβ) of Alzheimer disease is derived from the proteolytic processing of the amyloid precursor proteins (APPs), which are considered type I transmembrane proteins. Here we report that the soluble fraction of isolated adrenal medullary chromaffin granules (CG), a model neuronal...

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Veröffentlicht in:	Journal of neurochemistry 1995-05, Vol.64 (5), p.2140-2146
Hauptverfasser:	Vassilacopoulou, Dido, Ripellino, James A., Tezapsidis, Nikolaos, Hook, Vivian Y. H., Robakis, Nikolaos K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Medulla - ultrastructure Amyloid beta-Protein Precursor - analysis Amyloid beta-Protein Precursor - isolation & purification Amyloid beta-Protein Precursor - metabolism Amyloid peptide Animals Biological and medical sciences Calcium - pharmacology Cations, Divalent Cattle Chromaffin granules Chromaffin Granules - chemistry Cysteine Endopeptidases - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Electrophoresis, Polyacrylamide Gel Endopeptidases - metabolism Hot Temperature Hydrogen-Ion Concentration In vitro system Intracellular Membranes - chemistry Intracellular Membranes - enzymology Medical sciences Neurology pH dependence Protease inhibitors Protease Inhibitors - pharmacology Serine Endopeptidases - metabolism Solubility Soluble amyloid precursor protein Zinc - pharmacology
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