Chronic maternal hypoxia retards fetal growth and increases glucose utilization of select fetal tissues in the rat
The development of intrauterine growth retardation (IUGR) is frequently associated with fetal hypoxia, hypoglycemia, and abnormal fetal glucose metabolism. To determine the effects of hypoxia (without concomitant hypoglycemia) on fetal glucose metabolism, we continuously exposed pregnant rats to 10%...
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| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 1995-04, Vol.44 (4), p.532-537 |
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| creator | Lueder, Frederick L. Kim, Sun-Bum Buroker, Carolee A. Bangalore, Shrikar A. Ogata, Edward S. |
| description | The development of intrauterine growth retardation (IUGR) is frequently associated with fetal hypoxia, hypoglycemia, and abnormal fetal glucose metabolism. To determine the effects of hypoxia (without concomitant hypoglycemia) on fetal glucose metabolism, we continuously exposed pregnant rats to 10% (10.1 kPa) ambient oxygen from day 15 through day 20 of gestation (term, 21.5 days) and used radiolabeled 2-deoxyglucose (2DG) to measure in vivo relative glucose utilization (rGU) of several fetal tissues on day 20 of gestation. Pair-fed rats in room-air oxygen were used as controls. Maternal hypoxia resulted in significant IUGR, fetal hypoxia and acidosis, and fetal lactate accumulation on day 20 of gestation. Following 5 days of hypoxia, rGU values for fetal lung, heart, and kidney were increased by 61%, 54%, and 47%, respectively (
P < .05). rGU values for fetal brain, liver, muscle, and placenta were not significantly affected. Fetal plasma glucose concentrations were similar in hypoxic and control fetuses. We speculate that the increased rGU of hypoxic fetal tissues is due in part to anaerobic metabolism and increased glycolysis. |
| doi_str_mv | 10.1016/0026-0495(95)90063-2 |
| format | Article |
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P < .05). rGU values for fetal brain, liver, muscle, and placenta were not significantly affected. Fetal plasma glucose concentrations were similar in hypoxic and control fetuses. We speculate that the increased rGU of hypoxic fetal tissues is due in part to anaerobic metabolism and increased glycolysis.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/0026-0495(95)90063-2</identifier><identifier>PMID: 7723678</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Blood Glucose - analysis ; Chronic Disease ; Embryonic and Fetal Development ; Female ; Female genital diseases ; Fetal Blood ; Fetus - anatomy & histology ; Fetus - metabolism ; Gases - blood ; Glucose - metabolism ; Gynecology. Andrology. Obstetrics ; Hypoxia - physiopathology ; Insulin - blood ; Medical sciences ; Pregnancy ; Pregnancy Complications - physiopathology ; Pregnancy, Animal - blood ; Pregnancy, Animal - physiology ; Rats ; Rats, Sprague-Dawley ; Tumors ; Weight Gain</subject><ispartof>Metabolism, clinical and experimental, 1995-04, Vol.44 (4), p.532-537</ispartof><rights>1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-2327af811b351d3ac4642fbbe4fab8f682024cc7f1ba2f17b9554ecb90bde2973</citedby><cites>FETCH-LOGICAL-c386t-2327af811b351d3ac4642fbbe4fab8f682024cc7f1ba2f17b9554ecb90bde2973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0026-0495(95)90063-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3529981$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7723678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lueder, Frederick L.</creatorcontrib><creatorcontrib>Kim, Sun-Bum</creatorcontrib><creatorcontrib>Buroker, Carolee A.</creatorcontrib><creatorcontrib>Bangalore, Shrikar A.</creatorcontrib><creatorcontrib>Ogata, Edward S.</creatorcontrib><title>Chronic maternal hypoxia retards fetal growth and increases glucose utilization of select fetal tissues in the rat</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>The development of intrauterine growth retardation (IUGR) is frequently associated with fetal hypoxia, hypoglycemia, and abnormal fetal glucose metabolism. To determine the effects of hypoxia (without concomitant hypoglycemia) on fetal glucose metabolism, we continuously exposed pregnant rats to 10% (10.1 kPa) ambient oxygen from day 15 through day 20 of gestation (term, 21.5 days) and used radiolabeled 2-deoxyglucose (2DG) to measure in vivo relative glucose utilization (rGU) of several fetal tissues on day 20 of gestation. Pair-fed rats in room-air oxygen were used as controls. Maternal hypoxia resulted in significant IUGR, fetal hypoxia and acidosis, and fetal lactate accumulation on day 20 of gestation. Following 5 days of hypoxia, rGU values for fetal lung, heart, and kidney were increased by 61%, 54%, and 47%, respectively (
P < .05). rGU values for fetal brain, liver, muscle, and placenta were not significantly affected. Fetal plasma glucose concentrations were similar in hypoxic and control fetuses. We speculate that the increased rGU of hypoxic fetal tissues is due in part to anaerobic metabolism and increased glycolysis.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Chronic Disease</subject><subject>Embryonic and Fetal Development</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Fetal Blood</subject><subject>Fetus - anatomy & histology</subject><subject>Fetus - metabolism</subject><subject>Gases - blood</subject><subject>Glucose - metabolism</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hypoxia - physiopathology</subject><subject>Insulin - blood</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - physiopathology</subject><subject>Pregnancy, Animal - blood</subject><subject>Pregnancy, Animal - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Tumors</subject><subject>Weight Gain</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo67j6DxRyENFDa5LuTtKXBRn8ggUveg5JurITySRjklbXX2-aaeYoFLyHet6ieBB6TslbSih_RwjjHRmm8fU0vpkI4X3HHqAdHXvWSU7IQ7S7II_Rk1J-EEKEkPwKXQnBei7kDuX9IafoLT7qCjnqgA_3p_THa5yh6jwX7FoGfJfT73rAOs7YR5tBFyj4Liw2FcBL9cH_1dWniJPDBQLYuhWrL2VprI-4HgBnXZ-iR06HAs-2vEbfP374tv_c3X799GX__razveS1Yz0T2klKTT_Sudd24ANzxsDgtJGOS0bYYK1w1GjmqDDTOA5gzUTMDGwS_TV6db57yulne6Gqoy8WQtAR0lJUc8DYIGUDhzNocyolg1On7I863ytK1KparR7V6lGts6pWrNVebPcXc4T5Utrctv3Lba-L1cFlHa0vF6wf2TRJ2rCbMwbNxS8PWRXrIVqYfW4a1Zz8___4BwFlnHQ</recordid><startdate>19950401</startdate><enddate>19950401</enddate><creator>Lueder, Frederick L.</creator><creator>Kim, Sun-Bum</creator><creator>Buroker, Carolee A.</creator><creator>Bangalore, Shrikar A.</creator><creator>Ogata, Edward S.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950401</creationdate><title>Chronic maternal hypoxia retards fetal growth and increases glucose utilization of select fetal tissues in the rat</title><author>Lueder, Frederick L. ; Kim, Sun-Bum ; Buroker, Carolee A. ; Bangalore, Shrikar A. ; Ogata, Edward S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-2327af811b351d3ac4642fbbe4fab8f682024cc7f1ba2f17b9554ecb90bde2973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Chronic Disease</topic><topic>Embryonic and Fetal Development</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Fetal Blood</topic><topic>Fetus - anatomy & histology</topic><topic>Fetus - metabolism</topic><topic>Gases - blood</topic><topic>Glucose - metabolism</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hypoxia - physiopathology</topic><topic>Insulin - blood</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - physiopathology</topic><topic>Pregnancy, Animal - blood</topic><topic>Pregnancy, Animal - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Tumors</topic><topic>Weight Gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lueder, Frederick L.</creatorcontrib><creatorcontrib>Kim, Sun-Bum</creatorcontrib><creatorcontrib>Buroker, Carolee A.</creatorcontrib><creatorcontrib>Bangalore, Shrikar A.</creatorcontrib><creatorcontrib>Ogata, Edward S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lueder, Frederick L.</au><au>Kim, Sun-Bum</au><au>Buroker, Carolee A.</au><au>Bangalore, Shrikar A.</au><au>Ogata, Edward S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic maternal hypoxia retards fetal growth and increases glucose utilization of select fetal tissues in the rat</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>1995-04-01</date><risdate>1995</risdate><volume>44</volume><issue>4</issue><spage>532</spage><epage>537</epage><pages>532-537</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>The development of intrauterine growth retardation (IUGR) is frequently associated with fetal hypoxia, hypoglycemia, and abnormal fetal glucose metabolism. To determine the effects of hypoxia (without concomitant hypoglycemia) on fetal glucose metabolism, we continuously exposed pregnant rats to 10% (10.1 kPa) ambient oxygen from day 15 through day 20 of gestation (term, 21.5 days) and used radiolabeled 2-deoxyglucose (2DG) to measure in vivo relative glucose utilization (rGU) of several fetal tissues on day 20 of gestation. Pair-fed rats in room-air oxygen were used as controls. Maternal hypoxia resulted in significant IUGR, fetal hypoxia and acidosis, and fetal lactate accumulation on day 20 of gestation. Following 5 days of hypoxia, rGU values for fetal lung, heart, and kidney were increased by 61%, 54%, and 47%, respectively (
P < .05). rGU values for fetal brain, liver, muscle, and placenta were not significantly affected. Fetal plasma glucose concentrations were similar in hypoxic and control fetuses. We speculate that the increased rGU of hypoxic fetal tissues is due in part to anaerobic metabolism and increased glycolysis.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>7723678</pmid><doi>10.1016/0026-0495(95)90063-2</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Blood Glucose - analysis Chronic Disease Embryonic and Fetal Development Female Female genital diseases Fetal Blood Fetus - anatomy & histology Fetus - metabolism Gases - blood Glucose - metabolism Gynecology. Andrology. Obstetrics Hypoxia - physiopathology Insulin - blood Medical sciences Pregnancy Pregnancy Complications - physiopathology Pregnancy, Animal - blood Pregnancy, Animal - physiology Rats Rats, Sprague-Dawley Tumors Weight Gain |
| title | Chronic maternal hypoxia retards fetal growth and increases glucose utilization of select fetal tissues in the rat |
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