HLA-DRB11502 allele, subtype of DR15, is associated with susceptibility to ulcerative colitis and its progression
HLA-DRB1 allele typing was performed by the PCR-RFLP method on 59 ulcerative colitis (UC) patients and 136 healthy controls. Phenotypic frequencies of HLA-B52 and DR2 were significantly increased among the UC patients, serologically. DNA typing of HLA-DRB1 revealed that the genotypic frequency of DR...
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| Veröffentlicht in: | Digestive diseases and sciences 1995-04, Vol.40 (4), p.814-818 |
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| creator | FUTAMI, S AOYAMA, N NARUSE, T NOSE, M KASUGA, M HONSAKO, Y TAMURA, T MORIMOTO, S NAKASHIMA, T OHMOTO, A OKANO, H MIYAMOTO, M INABA, H |
| description | HLA-DRB1 allele typing was performed by the PCR-RFLP method on 59 ulcerative colitis (UC) patients and 136 healthy controls. Phenotypic frequencies of HLA-B52 and DR2 were significantly increased among the UC patients, serologically. DNA typing of HLA-DRB1 revealed that the genotypic frequency of DRB1*1502 was higher in UC than in the controls (49.2% vs 17.6%; P < 0.0001). In the analysis of clinical parameters, 82.8% of patients bearing DRB1*1502 were treated with corticosteroids. DRB1*1501 and DRB1*1502 differ in only one amino acid at residue 86 (valine vs glycine), and 66% of the UC patients carried two glycines at position 86 in the HLA-DR beta-chain (vs 51% of control; P < 0.05). These observations suggest that the presence of Gly-86 in the HLA beta-chain and surrounding amino acid sequence of HLA-DRB1*1502 is strongly associated with susceptibility to UC. |
| doi_str_mv | 10.1007/BF02064985 |
| format | Article |
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Phenotypic frequencies of HLA-B52 and DR2 were significantly increased among the UC patients, serologically. DNA typing of HLA-DRB1 revealed that the genotypic frequency of DRB1*1502 was higher in UC than in the controls (49.2% vs 17.6%; P < 0.0001). In the analysis of clinical parameters, 82.8% of patients bearing DRB1*1502 were treated with corticosteroids. DRB1*1501 and DRB1*1502 differ in only one amino acid at residue 86 (valine vs glycine), and 66% of the UC patients carried two glycines at position 86 in the HLA-DR beta-chain (vs 51% of control; P < 0.05). These observations suggest that the presence of Gly-86 in the HLA beta-chain and surrounding amino acid sequence of HLA-DRB1*1502 is strongly associated with susceptibility to UC.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/BF02064985</identifier><identifier>PMID: 7720475</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adolescent ; Adult ; Alleles ; Biological and medical sciences ; Colitis, Ulcerative - genetics ; Disease Susceptibility ; DNA - analysis ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Genotype ; Haplotypes ; HLA-DR Antigens - genetics ; HLA-DRB1 Chains ; Humans ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Phenotype ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><ispartof>Digestive diseases and sciences, 1995-04, Vol.40 (4), p.814-818</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c226t-e2b2c22f648f5dc0f97cd837c859ced3620307df1a2598395dd9e3f25bf364d3</citedby><cites>FETCH-LOGICAL-c226t-e2b2c22f648f5dc0f97cd837c859ced3620307df1a2598395dd9e3f25bf364d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3514575$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7720475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FUTAMI, S</creatorcontrib><creatorcontrib>AOYAMA, N</creatorcontrib><creatorcontrib>NARUSE, T</creatorcontrib><creatorcontrib>NOSE, M</creatorcontrib><creatorcontrib>KASUGA, M</creatorcontrib><creatorcontrib>HONSAKO, Y</creatorcontrib><creatorcontrib>TAMURA, T</creatorcontrib><creatorcontrib>MORIMOTO, S</creatorcontrib><creatorcontrib>NAKASHIMA, T</creatorcontrib><creatorcontrib>OHMOTO, A</creatorcontrib><creatorcontrib>OKANO, H</creatorcontrib><creatorcontrib>MIYAMOTO, M</creatorcontrib><creatorcontrib>INABA, H</creatorcontrib><title>HLA-DRB11502 allele, subtype of DR15, is associated with susceptibility to ulcerative colitis and its progression</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>HLA-DRB1 allele typing was performed by the PCR-RFLP method on 59 ulcerative colitis (UC) patients and 136 healthy controls. Phenotypic frequencies of HLA-B52 and DR2 were significantly increased among the UC patients, serologically. DNA typing of HLA-DRB1 revealed that the genotypic frequency of DRB1*1502 was higher in UC than in the controls (49.2% vs 17.6%; P < 0.0001). In the analysis of clinical parameters, 82.8% of patients bearing DRB1*1502 were treated with corticosteroids. DRB1*1501 and DRB1*1502 differ in only one amino acid at residue 86 (valine vs glycine), and 66% of the UC patients carried two glycines at position 86 in the HLA-DR beta-chain (vs 51% of control; P < 0.05). These observations suggest that the presence of Gly-86 in the HLA beta-chain and surrounding amino acid sequence of HLA-DRB1*1502 is strongly associated with susceptibility to UC.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Colitis, Ulcerative - genetics</subject><subject>Disease Susceptibility</subject><subject>DNA - analysis</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>HLA-DR Antigens - genetics</subject><subject>HLA-DRB1 Chains</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Phenotype</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Stomach. Duodenum. Small intestine. 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Liver. Pancreas. Abdomen</topic><topic>Genotype</topic><topic>Haplotypes</topic><topic>HLA-DR Antigens - genetics</topic><topic>HLA-DRB1 Chains</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Phenotype</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FUTAMI, S</creatorcontrib><creatorcontrib>AOYAMA, N</creatorcontrib><creatorcontrib>NARUSE, T</creatorcontrib><creatorcontrib>NOSE, M</creatorcontrib><creatorcontrib>KASUGA, M</creatorcontrib><creatorcontrib>HONSAKO, Y</creatorcontrib><creatorcontrib>TAMURA, T</creatorcontrib><creatorcontrib>MORIMOTO, S</creatorcontrib><creatorcontrib>NAKASHIMA, T</creatorcontrib><creatorcontrib>OHMOTO, A</creatorcontrib><creatorcontrib>OKANO, H</creatorcontrib><creatorcontrib>MIYAMOTO, M</creatorcontrib><creatorcontrib>INABA, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FUTAMI, S</au><au>AOYAMA, N</au><au>NARUSE, T</au><au>NOSE, M</au><au>KASUGA, M</au><au>HONSAKO, Y</au><au>TAMURA, T</au><au>MORIMOTO, S</au><au>NAKASHIMA, T</au><au>OHMOTO, A</au><au>OKANO, H</au><au>MIYAMOTO, M</au><au>INABA, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA-DRB11502 allele, subtype of DR15, is associated with susceptibility to ulcerative colitis and its progression</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>1995-04</date><risdate>1995</risdate><volume>40</volume><issue>4</issue><spage>814</spage><epage>818</epage><pages>814-818</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>HLA-DRB1 allele typing was performed by the PCR-RFLP method on 59 ulcerative colitis (UC) patients and 136 healthy controls. Phenotypic frequencies of HLA-B52 and DR2 were significantly increased among the UC patients, serologically. DNA typing of HLA-DRB1 revealed that the genotypic frequency of DRB1*1502 was higher in UC than in the controls (49.2% vs 17.6%; P < 0.0001). In the analysis of clinical parameters, 82.8% of patients bearing DRB1*1502 were treated with corticosteroids. DRB1*1501 and DRB1*1502 differ in only one amino acid at residue 86 (valine vs glycine), and 66% of the UC patients carried two glycines at position 86 in the HLA-DR beta-chain (vs 51% of control; P < 0.05). These observations suggest that the presence of Gly-86 in the HLA beta-chain and surrounding amino acid sequence of HLA-DRB1*1502 is strongly associated with susceptibility to UC.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>7720475</pmid><doi>10.1007/BF02064985</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Alleles Biological and medical sciences Colitis, Ulcerative - genetics Disease Susceptibility DNA - analysis Female Gastroenterology. Liver. Pancreas. Abdomen Genotype Haplotypes HLA-DR Antigens - genetics HLA-DRB1 Chains Humans Male Medical sciences Middle Aged Other diseases. Semiology Phenotype Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Stomach. Duodenum. Small intestine. Colon. Rectum. Anus |
| title | HLA-DRB11502 allele, subtype of DR15, is associated with susceptibility to ulcerative colitis and its progression |
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