Cloning of the β Cell High-Affinity Sulfonylurea Receptor: A Regulator of Insulin Secretion

Sulfonylureas are a class of drugs widely used to promote insulin secretion in the treatment of non-insulin-dependent diabetes mellitus. These drugs interact with the sulfonylurea receptor of pancreatic β cells and inhibit the conductance of adenosine triphosphate (ATP)-dependent potassium (K$_{ATP}...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1995-04, Vol.268 (5209), p.423-426
Hauptverfasser:	Aguilar-Bryan, Lydia, Nichols, Colin G., Wechsler, Sérgio W., Clement, John P., Boyd, A. E., González, Gabriela, Herrera-Sosa, Haydée, Nguy, Kimberly, Bryan, Joseph, Nelson, Daniel A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - metabolism Adenosine Triphosphate - metabolism Amino Acid Sequence Amino acids Animals ATP-Binding Cassette Transporters B cells Base Sequence Beta cells Biological and medical sciences Cell Line Cell lines Cell membranes Cells Cloning, Molecular Complementary DNA Cricetinae Deoxyribonucleic acid Diabetes DNA Fundamental and applied biological sciences. Psychology Genes. Genome Hamsters Hypoglycemic sulfonylureas Inhibition Insulin Insulin - metabolism Insulin Secretion Islets of Langerhans - metabolism Libraries Membranes Messenger RNA Molecular and cellular biology Molecular genetics Molecular Sequence Data Multivariate Analysis Narcotics Nucleotides Phosphorylation Physiological aspects Potassium channels Potassium Channels - chemistry Potassium Channels - genetics Potassium Channels - metabolism Potassium Channels, Inwardly Rectifying Protein Folding Protein Structure, Secondary Proteins Receptors Receptors, Drug - chemistry Receptors, Drug - genetics Receptors, Drug - metabolism Sequence Alignment Sulfonylurea compounds Sulfonylurea Compounds - metabolism Sulfonylurea Receptors Sulfonylureas Transcripts (Written Records) Transfection Tumor Cells, Cultured Type 2 diabetes
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Beschreibung
Zusammenfassung:	Sulfonylureas are a class of drugs widely used to promote insulin secretion in the treatment of non-insulin-dependent diabetes mellitus. These drugs interact with the sulfonylurea receptor of pancreatic β cells and inhibit the conductance of adenosine triphosphate (ATP)-dependent potassium (K$_{ATP}$) channels. Cloning of complementary DNAs for the high-affinity sulfonylurea receptor indicates that it is a member of the ATP-binding cassette or traffic ATPase superfamily with multiple membrane-spanning domains and two nucleotide binding folds. The results suggest that the sulfonylurea receptor may sense changes in ATP and ADP concentration, affect K$_{ATP}$ channel activity, and thereby modulate insulin release.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.7716547