Integrins and Signal Transduction Pathways: The Road Taken
Adhesive interactions play critical roles in directing the migration, proliferation, and differentiation of cells; aberrations in such interactions can lead to pathological disorders. These adhesive interactions, mediated by cell surface receptors that bind to ligands on adjacent cells or in the ext...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1995-04, Vol.268 (5208), p.233-239 |
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| container_issue | 5208 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Clark, Edwin A. Brugge, Joan S. |
| description | Adhesive interactions play critical roles in directing the migration, proliferation, and differentiation of cells; aberrations in such interactions can lead to pathological disorders. These adhesive interactions, mediated by cell surface receptors that bind to ligands on adjacent cells or in the extracellular matrix, also regulate intracellular signal transduction pathways that control adhesion-induced changes in cell physiology. Though the extracellular molecular interactions involving many adhesion receptors have been well characterized, the adhesion-dependent intracellular signaling events that regulate these physiological alterations have only begun to be elucidated. This article will focus on recent advances in our understanding of intracellular signal transduction pathways regulated by the integrin family of adhesion receptors. |
| doi_str_mv | 10.1126/science.7716514 |
| format | Article |
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These adhesive interactions, mediated by cell surface receptors that bind to ligands on adjacent cells or in the extracellular matrix, also regulate intracellular signal transduction pathways that control adhesion-induced changes in cell physiology. Though the extracellular molecular interactions involving many adhesion receptors have been well characterized, the adhesion-dependent intracellular signaling events that regulate these physiological alterations have only begun to be elucidated. This article will focus on recent advances in our understanding of intracellular signal transduction pathways regulated by the integrin family of adhesion receptors.</description><subject>Animals</subject><subject>Calcium - metabolism</subject><subject>Cell Adhesion</subject><subject>Cell adhesion molecules</subject><subject>Cell growth</subject><subject>Cellular biology</subject><subject>Cellular signal transduction</subject><subject>Cytokines - physiology</subject><subject>Cytoskeletal Proteins - metabolism</subject><subject>Extracellular matrix</subject><subject>Extracellular Matrix Proteins - metabolism</subject><subject>Feedback (Response)</subject><subject>Focal adhesions</subject><subject>Gene Expression</subject><subject>Gene expression regulation</subject><subject>GTP-Binding Proteins - metabolism</subject><subject>Humans</subject><subject>Integrins</subject><subject>Integrins - 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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1995-04, Vol.268 (5208), p.233-239 |
| issn | 0036-8075 1095-9203 |
| language | eng |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Animals Calcium - metabolism Cell Adhesion Cell adhesion molecules Cell growth Cellular biology Cellular signal transduction Cytokines - physiology Cytoskeletal Proteins - metabolism Extracellular matrix Extracellular Matrix Proteins - metabolism Feedback (Response) Focal adhesions Gene Expression Gene expression regulation GTP-Binding Proteins - metabolism Humans Integrins Integrins - physiology Ligands Membranes Phosphorylation Phosphotransferases - metabolism Physiological regulation Protein Tyrosine Phosphatases - metabolism Proteins Receptors Signal Transduction |
| title | Integrins and Signal Transduction Pathways: The Road Taken |
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