Prevention of infection in acute leukemia: a prospective randomized study on the efficacy of two different drug regimens for antimicrobial prophylaxis
In a prospective study patients with acute leukemia undergoing remission induction therapy were randomized to receive either a regimen of non-absorbable antimicrobial drugs (colistin and neomycin) or of absorbable and non-absorbable drugs (trimethoprim-sulfamethoxazole [TMP-SMZ] and colistin) for an...
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| Veröffentlicht in: | Infection 1986-09, Vol.14 (5), p.226-232 |
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| creator | KURRLE, E DEKKER, A. W GAUS, W HARALAMBIE, E KRIEGER, D ROZENBERG-ARSKA, M DE VRIES-HOSPERS, H. G VAN DER WAAIJ, D WENDT, F |
| description | In a prospective study patients with acute leukemia undergoing remission induction therapy were randomized to receive either a regimen of non-absorbable antimicrobial drugs (colistin and neomycin) or of absorbable and non-absorbable drugs (trimethoprim-sulfamethoxazole [TMP-SMZ] and colistin) for antibacterial prophylaxis. For antifungal prophylaxis patients in both groups were given oral amphotericin B. The proportion of patients without acquired infections and the median of study time to the first acquired infection did not differ significantly between the two treatment groups (p greater than 0.05). Septicemias occurred in nine out of 49 recipients of colistin and neomycin and in one out of 56 patients receiving TMP-SMZ and colistin (p = 0.03). Localized infections and fever episodes without proven infections were equally distributed between the two groups. The incidence of febrile days and of days on parenteral antibiotic therapy was significantly lower in the group given TMP-SMZ and colistin (p less than 0.05). The duration of severe granulocytopenia and thrombocytopenia did not differ significantly between the two groups (p greater than 0.05). |
| doi_str_mv | 10.1007/BF01644268 |
| format | Article |
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W ; GAUS, W ; HARALAMBIE, E ; KRIEGER, D ; ROZENBERG-ARSKA, M ; DE VRIES-HOSPERS, H. G ; VAN DER WAAIJ, D ; WENDT, F</creator><creatorcontrib>KURRLE, E ; DEKKER, A. W ; GAUS, W ; HARALAMBIE, E ; KRIEGER, D ; ROZENBERG-ARSKA, M ; DE VRIES-HOSPERS, H. G ; VAN DER WAAIJ, D ; WENDT, F</creatorcontrib><description>In a prospective study patients with acute leukemia undergoing remission induction therapy were randomized to receive either a regimen of non-absorbable antimicrobial drugs (colistin and neomycin) or of absorbable and non-absorbable drugs (trimethoprim-sulfamethoxazole [TMP-SMZ] and colistin) for antibacterial prophylaxis. For antifungal prophylaxis patients in both groups were given oral amphotericin B. The proportion of patients without acquired infections and the median of study time to the first acquired infection did not differ significantly between the two treatment groups (p greater than 0.05). Septicemias occurred in nine out of 49 recipients of colistin and neomycin and in one out of 56 patients receiving TMP-SMZ and colistin (p = 0.03). Localized infections and fever episodes without proven infections were equally distributed between the two groups. The incidence of febrile days and of days on parenteral antibiotic therapy was significantly lower in the group given TMP-SMZ and colistin (p less than 0.05). The duration of severe granulocytopenia and thrombocytopenia did not differ significantly between the two groups (p greater than 0.05).</description><identifier>ISSN: 0300-8126</identifier><identifier>EISSN: 1439-0973</identifier><identifier>DOI: 10.1007/BF01644268</identifier><identifier>PMID: 3491791</identifier><identifier>CODEN: IFTNAL</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adolescent ; Adult ; Amphotericin B - therapeutic use ; Anti-Infective Agents - therapeutic use ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacterial Infections - complications ; Bacterial Infections - epidemiology ; Bacterial Infections - prevention & control ; Biological and medical sciences ; Colistin - therapeutic use ; Drug Combinations - therapeutic use ; Drug Therapy, Combination ; Female ; Humans ; Leukemia, Lymphoid - complications ; Leukemia, Lymphoid - drug therapy ; Leukemia, Myeloid, Acute - complications ; Leukemia, Myeloid, Acute - drug therapy ; Male ; Medical sciences ; Middle Aged ; Neomycin - therapeutic use ; Pharmacology. 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W</creatorcontrib><creatorcontrib>GAUS, W</creatorcontrib><creatorcontrib>HARALAMBIE, E</creatorcontrib><creatorcontrib>KRIEGER, D</creatorcontrib><creatorcontrib>ROZENBERG-ARSKA, M</creatorcontrib><creatorcontrib>DE VRIES-HOSPERS, H. G</creatorcontrib><creatorcontrib>VAN DER WAAIJ, D</creatorcontrib><creatorcontrib>WENDT, F</creatorcontrib><title>Prevention of infection in acute leukemia: a prospective randomized study on the efficacy of two different drug regimens for antimicrobial prophylaxis</title><title>Infection</title><addtitle>Infection</addtitle><description>In a prospective study patients with acute leukemia undergoing remission induction therapy were randomized to receive either a regimen of non-absorbable antimicrobial drugs (colistin and neomycin) or of absorbable and non-absorbable drugs (trimethoprim-sulfamethoxazole [TMP-SMZ] and colistin) for antibacterial prophylaxis. For antifungal prophylaxis patients in both groups were given oral amphotericin B. The proportion of patients without acquired infections and the median of study time to the first acquired infection did not differ significantly between the two treatment groups (p greater than 0.05). Septicemias occurred in nine out of 49 recipients of colistin and neomycin and in one out of 56 patients receiving TMP-SMZ and colistin (p = 0.03). Localized infections and fever episodes without proven infections were equally distributed between the two groups. The incidence of febrile days and of days on parenteral antibiotic therapy was significantly lower in the group given TMP-SMZ and colistin (p less than 0.05). The duration of severe granulocytopenia and thrombocytopenia did not differ significantly between the two groups (p greater than 0.05).</description><subject>Adolescent</subject><subject>Adult</subject><subject>Amphotericin B - therapeutic use</subject><subject>Anti-Infective Agents - therapeutic use</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacterial Infections - complications</subject><subject>Bacterial Infections - epidemiology</subject><subject>Bacterial Infections - prevention & control</subject><subject>Biological and medical sciences</subject><subject>Colistin - therapeutic use</subject><subject>Drug Combinations - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Humans</subject><subject>Leukemia, Lymphoid - complications</subject><subject>Leukemia, Lymphoid - drug therapy</subject><subject>Leukemia, Myeloid, Acute - complications</subject><subject>Leukemia, Myeloid, Acute - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neomycin - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>Random Allocation</subject><subject>Remission Induction</subject><subject>Sulfamethoxazole - therapeutic use</subject><subject>Trimethoprim - therapeutic use</subject><subject>Trimethoprim, Sulfamethoxazole Drug Combination</subject><issn>0300-8126</issn><issn>1439-0973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1O3DAUha0KBMO0m-6RvEBdIAXs2I7j7lrEnzQSLNp1dONcg0t-BjsZOn0QnhdPZ0SXXVnW_fwdXR9CPnN2xhnT59-vGC-kzIvyA5lxKUzGjBZ7ZMYEY1nJ8-KQHMX4izGmjNQH5EBIw7XhM_J6H3CF_eiHng6O-t6h_XvxPQU7jUhbnJ6w8_CVAl2GIS43wAppgL4ZOv8HGxrHqVnT9Gh8RIrOeQt2vdGNLwNtvHMYUgRtwvRAAz74DvtI3RAopODO2zDUHtqNffm4buG3jx_JvoM24qfdOSc_ry5_XNxki7vr24tvi8zmSo9ZXYgaDJgiZ0KgrRlXUjuhawGgjKpLbJoCUKoSlSxKW3JTS63yEp0wqJmYky9bb8p-njCOVeejxbaFHocpVlrnXDH5f5BLVSSxTODpFkxbxRjQVcvgOwjrirNq01b1r60EH--sU91h847u6knzk90cooXWpT-3Pr5jJddcpb7fAFr1nrk</recordid><startdate>198609</startdate><enddate>198609</enddate><creator>KURRLE, E</creator><creator>DEKKER, A. 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G ; VAN DER WAAIJ, D ; WENDT, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c257t-b63ba9a962033ecb01547f37b3aa595b8edd6ae458e5468c819b47528ef39e703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Amphotericin B - therapeutic use</topic><topic>Anti-Infective Agents - therapeutic use</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Bacterial Infections - complications</topic><topic>Bacterial Infections - epidemiology</topic><topic>Bacterial Infections - prevention & control</topic><topic>Biological and medical sciences</topic><topic>Colistin - therapeutic use</topic><topic>Drug Combinations - therapeutic use</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Humans</topic><topic>Leukemia, Lymphoid - complications</topic><topic>Leukemia, Lymphoid - drug therapy</topic><topic>Leukemia, Myeloid, Acute - complications</topic><topic>Leukemia, Myeloid, Acute - drug therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neomycin - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><topic>Random Allocation</topic><topic>Remission Induction</topic><topic>Sulfamethoxazole - therapeutic use</topic><topic>Trimethoprim - therapeutic use</topic><topic>Trimethoprim, Sulfamethoxazole Drug Combination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KURRLE, E</creatorcontrib><creatorcontrib>DEKKER, A. W</creatorcontrib><creatorcontrib>GAUS, W</creatorcontrib><creatorcontrib>HARALAMBIE, E</creatorcontrib><creatorcontrib>KRIEGER, D</creatorcontrib><creatorcontrib>ROZENBERG-ARSKA, M</creatorcontrib><creatorcontrib>DE VRIES-HOSPERS, H. 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The proportion of patients without acquired infections and the median of study time to the first acquired infection did not differ significantly between the two treatment groups (p greater than 0.05). Septicemias occurred in nine out of 49 recipients of colistin and neomycin and in one out of 56 patients receiving TMP-SMZ and colistin (p = 0.03). Localized infections and fever episodes without proven infections were equally distributed between the two groups. The incidence of febrile days and of days on parenteral antibiotic therapy was significantly lower in the group given TMP-SMZ and colistin (p less than 0.05). The duration of severe granulocytopenia and thrombocytopenia did not differ significantly between the two groups (p greater than 0.05).</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>3491791</pmid><doi>10.1007/BF01644268</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-8126 |
| ispartof | Infection, 1986-09, Vol.14 (5), p.226-232 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Adult Amphotericin B - therapeutic use Anti-Infective Agents - therapeutic use Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial Infections - complications Bacterial Infections - epidemiology Bacterial Infections - prevention & control Biological and medical sciences Colistin - therapeutic use Drug Combinations - therapeutic use Drug Therapy, Combination Female Humans Leukemia, Lymphoid - complications Leukemia, Lymphoid - drug therapy Leukemia, Myeloid, Acute - complications Leukemia, Myeloid, Acute - drug therapy Male Medical sciences Middle Aged Neomycin - therapeutic use Pharmacology. Drug treatments Prospective Studies Random Allocation Remission Induction Sulfamethoxazole - therapeutic use Trimethoprim - therapeutic use Trimethoprim, Sulfamethoxazole Drug Combination |
| title | Prevention of infection in acute leukemia: a prospective randomized study on the efficacy of two different drug regimens for antimicrobial prophylaxis |
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