HLA-D restriction of “naturally occurring” MLR suppressor cells in acquired common variable hypogammaglobulinemia
Cells with capacity to suppress the mixed lymphocyte response (MLR) were detected in two patients with acquired common variable hypogammaglobulinemia (ACVH). No specificity with respect to the stimulating HLA type was observed. In one case of ACVH available for extensive study, there was evidence fo...
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| Veröffentlicht in: | Human immunology 1986-12, Vol.17 (4), p.480-489 |
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| container_title | Human immunology |
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| creator | Hashemi, Sofia Hsu, Susan H. Bias, Wilma B. |
| description | Cells with capacity to suppress the mixed lymphocyte response (MLR) were detected in two patients with acquired common variable hypogammaglobulinemia (ACVH). No specificity with respect to the stimulating HLA type was observed. In one case of ACVH available for extensive study, there was evidence for HLA-D restriction of the suppressor cells. The patient's lymphocytes specifically suppressed the MLR of subjects who carried the same HLA-D type. Family studies confirmed that the suppressor activity was restricted to HLA-D, not DR, and segregated with the appropriate HLA haplotype. These observations suggest that an immune suppressor gene mapping in the HLA region may be involved in the pathogenesis of common variable hypogammaglobulinemia. |
| doi_str_mv | 10.1016/0198-8859(86)90306-X |
| format | Article |
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No specificity with respect to the stimulating HLA type was observed. In one case of ACVH available for extensive study, there was evidence for HLA-D restriction of the suppressor cells. The patient's lymphocytes specifically suppressed the MLR of subjects who carried the same HLA-D type. Family studies confirmed that the suppressor activity was restricted to HLA-D, not DR, and segregated with the appropriate HLA haplotype. These observations suggest that an immune suppressor gene mapping in the HLA region may be involved in the pathogenesis of common variable hypogammaglobulinemia.</description><identifier>ISSN: 0198-8859</identifier><identifier>EISSN: 1879-1166</identifier><identifier>DOI: 10.1016/0198-8859(86)90306-X</identifier><identifier>PMID: 2947885</identifier><identifier>CODEN: HUIMDQ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Agammaglobulinemia - genetics ; Agammaglobulinemia - immunology ; Applied sciences ; Exact sciences and technology ; Female ; Genes, MHC Class II ; HLA-D Antigens - genetics ; HLA-D Antigens - immunology ; Humans ; Lymphocyte Culture Test, Mixed ; Middle Aged ; Other techniques and industries ; T-Lymphocytes, Regulatory - immunology</subject><ispartof>Human immunology, 1986-12, Vol.17 (4), p.480-489</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c366t-5da52d88e10937399f42fc4e208f752e6dcc565543ff310d71f25f88e149be323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0198-8859(86)90306-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8378130$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2947885$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hashemi, Sofia</creatorcontrib><creatorcontrib>Hsu, Susan H.</creatorcontrib><creatorcontrib>Bias, Wilma B.</creatorcontrib><title>HLA-D restriction of “naturally occurring” MLR suppressor cells in acquired common variable hypogammaglobulinemia</title><title>Human immunology</title><addtitle>Hum Immunol</addtitle><description>Cells with capacity to suppress the mixed lymphocyte response (MLR) were detected in two patients with acquired common variable hypogammaglobulinemia (ACVH). No specificity with respect to the stimulating HLA type was observed. In one case of ACVH available for extensive study, there was evidence for HLA-D restriction of the suppressor cells. The patient's lymphocytes specifically suppressed the MLR of subjects who carried the same HLA-D type. Family studies confirmed that the suppressor activity was restricted to HLA-D, not DR, and segregated with the appropriate HLA haplotype. These observations suggest that an immune suppressor gene mapping in the HLA region may be involved in the pathogenesis of common variable hypogammaglobulinemia.</description><subject>Agammaglobulinemia - genetics</subject><subject>Agammaglobulinemia - immunology</subject><subject>Applied sciences</subject><subject>Exact sciences and technology</subject><subject>Female</subject><subject>Genes, MHC Class II</subject><subject>HLA-D Antigens - genetics</subject><subject>HLA-D Antigens - immunology</subject><subject>Humans</subject><subject>Lymphocyte Culture Test, Mixed</subject><subject>Middle Aged</subject><subject>Other techniques and industries</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><issn>0198-8859</issn><issn>1879-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2KFDEUhYMoYzv6BgpZiDiL0qSSys9GGEbHEVoEUZhdSKeSNpKq1CSVgd7Ng-jLzZOYspte6iqQ-53DvecA8ByjNxhh9hZhKRohOvlasDOJCGLN9QOwwoLLBmPGHoLVEXkMnuT8EyHEEacn4KSVlNf_FShX6_PmPUw2z8mb2ccRRgfv736Nei5Jh7CD0ZiSkh-393e_4ef1V5jLNFVBjgkaG0KGfoTa3BSfbA9NHIZqcquT15tg4Y_dFLd6GPQ2xE0JfrSD10_BI6dDts8O7yn4fvnh28VVs_7y8dPF-boxhLG56Xrdtb0QFiNJOJHS0dYZalskHO9ay3pjOtZ1lDhHMOo5dm3nFp7KjSUtOQWv9r5Tijel3qgGn5ed9WhjyYrzFlPE8X9BTJnkGC2OdA-aFHNO1qkp-UGnncJILbWoJXO1ZK4EU39rUddV9uLgXzaD7Y-iQw91_vIw19no4JIejc9HTBAuMEEVe7fHbA3t1tuksvF2NLav2ZtZ9dH_e48_xYyscQ</recordid><startdate>19861201</startdate><enddate>19861201</enddate><creator>Hashemi, Sofia</creator><creator>Hsu, Susan H.</creator><creator>Bias, Wilma B.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19861201</creationdate><title>HLA-D restriction of “naturally occurring” MLR suppressor cells in acquired common variable hypogammaglobulinemia</title><author>Hashemi, Sofia ; Hsu, Susan H. ; Bias, Wilma B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-5da52d88e10937399f42fc4e208f752e6dcc565543ff310d71f25f88e149be323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Agammaglobulinemia - genetics</topic><topic>Agammaglobulinemia - immunology</topic><topic>Applied sciences</topic><topic>Exact sciences and technology</topic><topic>Female</topic><topic>Genes, MHC Class II</topic><topic>HLA-D Antigens - genetics</topic><topic>HLA-D Antigens - immunology</topic><topic>Humans</topic><topic>Lymphocyte Culture Test, Mixed</topic><topic>Middle Aged</topic><topic>Other techniques and industries</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hashemi, Sofia</creatorcontrib><creatorcontrib>Hsu, Susan H.</creatorcontrib><creatorcontrib>Bias, Wilma B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hashemi, Sofia</au><au>Hsu, Susan H.</au><au>Bias, Wilma B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA-D restriction of “naturally occurring” MLR suppressor cells in acquired common variable hypogammaglobulinemia</atitle><jtitle>Human immunology</jtitle><addtitle>Hum Immunol</addtitle><date>1986-12-01</date><risdate>1986</risdate><volume>17</volume><issue>4</issue><spage>480</spage><epage>489</epage><pages>480-489</pages><issn>0198-8859</issn><eissn>1879-1166</eissn><coden>HUIMDQ</coden><abstract>Cells with capacity to suppress the mixed lymphocyte response (MLR) were detected in two patients with acquired common variable hypogammaglobulinemia (ACVH). No specificity with respect to the stimulating HLA type was observed. In one case of ACVH available for extensive study, there was evidence for HLA-D restriction of the suppressor cells. The patient's lymphocytes specifically suppressed the MLR of subjects who carried the same HLA-D type. Family studies confirmed that the suppressor activity was restricted to HLA-D, not DR, and segregated with the appropriate HLA haplotype. These observations suggest that an immune suppressor gene mapping in the HLA region may be involved in the pathogenesis of common variable hypogammaglobulinemia.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2947885</pmid><doi>10.1016/0198-8859(86)90306-X</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0198-8859 |
| ispartof | Human immunology, 1986-12, Vol.17 (4), p.480-489 |
| issn | 0198-8859 1879-1166 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77214071 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Agammaglobulinemia - genetics Agammaglobulinemia - immunology Applied sciences Exact sciences and technology Female Genes, MHC Class II HLA-D Antigens - genetics HLA-D Antigens - immunology Humans Lymphocyte Culture Test, Mixed Middle Aged Other techniques and industries T-Lymphocytes, Regulatory - immunology |
| title | HLA-D restriction of “naturally occurring” MLR suppressor cells in acquired common variable hypogammaglobulinemia |
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