Combining Two Mutations of Human Interleukin-6 That Affect gp130 Activation Results in a Potent Interleukin-6 Receptor Antagonist on Human Myeloma Cells (∗)

The pleiotropic cytokine interleukin-6 (IL-6) interacts with the specific ligand binding subunit (IL-6Rα) of the IL-6 receptor, and this complex associates with the signal-transducing subunit gp130 (IL-6Rβ). Human IL-6 acts on human and murine cells, whereas murine IL-6 is only active on murine cell...

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Veröffentlicht in:	The Journal of biological chemistry 1995-04, Vol.270 (14), p.8158-8163
Hauptverfasser:	Ehlers, Marc, de Hon, Floris D., Bos, Hanny Klaasse, Horsten, Ursula, Kurapkat, Günther, van De Leur, Hildegard Schmitz, Grötzinger, Joachim, Wollmer, Axel, Brakenhoff, Just P.J., Rose-John, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD Base Sequence Cytokine Receptor gp130 Humans Interleukin-6 - chemistry Interleukin-6 - genetics Membrane Glycoproteins - metabolism Mice Molecular Sequence Data Multiple Myeloma - metabolism Multiple Myeloma - pathology Oligodeoxyribonucleotides Point Mutation Protein Conformation Receptors, Interleukin - antagonists & inhibitors Receptors, Interleukin-6 Tumor Cells, Cultured
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