Neuromuscular transmission in the murine mutants “motor end-plate disease” and “jolting”
Mice with the inherited disorder “motor end-plate disease” suffered from a progressive neuromuscular weakness and muscular wasting. The weakness resulted from a failure of evoked transmitter release from the motor nerve terminals. The failure in transmission was all-or-nothing in nature. The numbers...
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| Veröffentlicht in: | Journal of the neurological sciences 1986-12, Vol.76 (2), p.239-253 |
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| creator | Harris, J.B. Pollard, Sandra L. |
| description | Mice with the inherited disorder “motor end-plate disease” suffered from a progressive neuromuscular weakness and muscular wasting. The weakness resulted from a failure of evoked transmitter release from the motor nerve terminals. The failure in transmission was all-or-nothing in nature. The numbers of muscle fibres in skeletal muscle and myelinated axons in several major nerve trunks were no different from normal. The loss in muscle bulk was caused by the neuromuscular defect and not from a loss of motor units or muscle fibres.
The inherited murine disorder “jolting” was allelic with “motor end-plate disease”. Affected “jolting” mice suffered no detectable morphological abnormality in skeletal muscle or peripheral nerve. The physiological properties of skeletal muscle and the characteristics of neuromuscular transmission were indistinguishable from normal. |
| doi_str_mv | 10.1016/0022-510X(86)90172-3 |
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The inherited murine disorder “jolting” was allelic with “motor end-plate disease”. Affected “jolting” mice suffered no detectable morphological abnormality in skeletal muscle or peripheral nerve. The physiological properties of skeletal muscle and the characteristics of neuromuscular transmission were indistinguishable from normal.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/0022-510X(86)90172-3</identifier><identifier>PMID: 3025377</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Action Potentials ; Age Factors ; Animals ; Biological and medical sciences ; Cell Count ; Electric Stimulation ; Female ; Jolting ; Male ; Medical sciences ; Membrane Potentials ; Mice ; Mice, Neurologic Mutants ; Motor end-plate disease ; Motor Endplate - physiopathology ; Mouse ; Muscles - pathology ; Muscles - physiopathology ; mutants ; Nerve Fibers, Myelinated - pathology ; nerve transmission ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Neuromuscular Diseases - pathology ; Neuromuscular Diseases - physiopathology ; Neuromuscular Junction - pathology ; Neuromuscular Junction - physiopathology ; neuromuscular junctions ; Neuromuscular transmission ; Peripheral Nerves - pathology ; Synaptic Transmission</subject><ispartof>Journal of the neurological sciences, 1986-12, Vol.76 (2), p.239-253</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-3f1507a3d877dd1c0affe5f20b00aa289219393c77ac759b054c06c5baeb04993</citedby><cites>FETCH-LOGICAL-c417t-3f1507a3d877dd1c0affe5f20b00aa289219393c77ac759b054c06c5baeb04993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0022-510X(86)90172-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8038599$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3025377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harris, J.B.</creatorcontrib><creatorcontrib>Pollard, Sandra L.</creatorcontrib><title>Neuromuscular transmission in the murine mutants “motor end-plate disease” and “jolting”</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>Mice with the inherited disorder “motor end-plate disease” suffered from a progressive neuromuscular weakness and muscular wasting. The weakness resulted from a failure of evoked transmitter release from the motor nerve terminals. The failure in transmission was all-or-nothing in nature. The numbers of muscle fibres in skeletal muscle and myelinated axons in several major nerve trunks were no different from normal. The loss in muscle bulk was caused by the neuromuscular defect and not from a loss of motor units or muscle fibres.
The inherited murine disorder “jolting” was allelic with “motor end-plate disease”. Affected “jolting” mice suffered no detectable morphological abnormality in skeletal muscle or peripheral nerve. The physiological properties of skeletal muscle and the characteristics of neuromuscular transmission were indistinguishable from normal.</description><subject>Action Potentials</subject><subject>Age Factors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Count</subject><subject>Electric Stimulation</subject><subject>Female</subject><subject>Jolting</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Potentials</subject><subject>Mice</subject><subject>Mice, Neurologic Mutants</subject><subject>Motor end-plate disease</subject><subject>Motor Endplate - physiopathology</subject><subject>Mouse</subject><subject>Muscles - pathology</subject><subject>Muscles - physiopathology</subject><subject>mutants</subject><subject>Nerve Fibers, Myelinated - pathology</subject><subject>nerve transmission</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Neuromuscular Diseases - pathology</subject><subject>Neuromuscular Diseases - physiopathology</subject><subject>Neuromuscular Junction - pathology</subject><subject>Neuromuscular Junction - physiopathology</subject><subject>neuromuscular junctions</subject><subject>Neuromuscular transmission</subject><subject>Peripheral Nerves - pathology</subject><subject>Synaptic Transmission</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQQC0EKtuWPwApB1SVQ-g4jmPngoSqtiBV5QISN-PYE3CV2IvtVOqtH9L-XL-EpLvaYzmNNPNmNPOGkLcUPlKgzQlAVZWcws9j2XxogYqqZC_IikohSy4le0lWO-Q12U_pGgAaKds9sseg4kyIFfl1hVMM45TMNOhY5Kh9Gl1KLvjC-SL_wWKcovNLyNrnVDze3Y8hh1igt-V60BkL6xLqhI93D4X2diGuw5Cd_z1nDsmrXg8J32zjAflxfvb99Et5-e3i6-nny9LUVOSS9ZSD0MxKIaylBnTfI-8r6AC0rmRb0Za1zAihjeBtB7w20Bjeaeygblt2QI42c9cx_J0wZTWfYXAYtMcwJSVERUHU8F-Q1k3DWC1nsN6AJoaUIvZqHd2o462ioJYPqEWvWvQq2ainDyg2t73bzp-6Ee2uaat8rr_f1nUyeuhn48alHSaBSf50z6cNhrO0G4dRJePQG7QuosnKBvf8Hv8A6bmmmw</recordid><startdate>19861201</startdate><enddate>19861201</enddate><creator>Harris, J.B.</creator><creator>Pollard, Sandra L.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19861201</creationdate><title>Neuromuscular transmission in the murine mutants “motor end-plate disease” and “jolting”</title><author>Harris, J.B. ; Pollard, Sandra L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-3f1507a3d877dd1c0affe5f20b00aa289219393c77ac759b054c06c5baeb04993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Action Potentials</topic><topic>Age Factors</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Count</topic><topic>Electric Stimulation</topic><topic>Female</topic><topic>Jolting</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Potentials</topic><topic>Mice</topic><topic>Mice, Neurologic Mutants</topic><topic>Motor end-plate disease</topic><topic>Motor Endplate - physiopathology</topic><topic>Mouse</topic><topic>Muscles - pathology</topic><topic>Muscles - physiopathology</topic><topic>mutants</topic><topic>Nerve Fibers, Myelinated - pathology</topic><topic>nerve transmission</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Neuromuscular Diseases - pathology</topic><topic>Neuromuscular Diseases - physiopathology</topic><topic>Neuromuscular Junction - pathology</topic><topic>Neuromuscular Junction - physiopathology</topic><topic>neuromuscular junctions</topic><topic>Neuromuscular transmission</topic><topic>Peripheral Nerves - pathology</topic><topic>Synaptic Transmission</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harris, J.B.</creatorcontrib><creatorcontrib>Pollard, Sandra L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harris, J.B.</au><au>Pollard, Sandra L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuromuscular transmission in the murine mutants “motor end-plate disease” and “jolting”</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1986-12-01</date><risdate>1986</risdate><volume>76</volume><issue>2</issue><spage>239</spage><epage>253</epage><pages>239-253</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>Mice with the inherited disorder “motor end-plate disease” suffered from a progressive neuromuscular weakness and muscular wasting. The weakness resulted from a failure of evoked transmitter release from the motor nerve terminals. The failure in transmission was all-or-nothing in nature. The numbers of muscle fibres in skeletal muscle and myelinated axons in several major nerve trunks were no different from normal. The loss in muscle bulk was caused by the neuromuscular defect and not from a loss of motor units or muscle fibres.
The inherited murine disorder “jolting” was allelic with “motor end-plate disease”. Affected “jolting” mice suffered no detectable morphological abnormality in skeletal muscle or peripheral nerve. The physiological properties of skeletal muscle and the characteristics of neuromuscular transmission were indistinguishable from normal.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>3025377</pmid><doi>10.1016/0022-510X(86)90172-3</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-510X |
| ispartof | Journal of the neurological sciences, 1986-12, Vol.76 (2), p.239-253 |
| issn | 0022-510X 1878-5883 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Action Potentials Age Factors Animals Biological and medical sciences Cell Count Electric Stimulation Female Jolting Male Medical sciences Membrane Potentials Mice Mice, Neurologic Mutants Motor end-plate disease Motor Endplate - physiopathology Mouse Muscles - pathology Muscles - physiopathology mutants Nerve Fibers, Myelinated - pathology nerve transmission Nervous system involvement in other diseases. Miscellaneous Neurology Neuromuscular Diseases - pathology Neuromuscular Diseases - physiopathology Neuromuscular Junction - pathology Neuromuscular Junction - physiopathology neuromuscular junctions Neuromuscular transmission Peripheral Nerves - pathology Synaptic Transmission |
| title | Neuromuscular transmission in the murine mutants “motor end-plate disease” and “jolting” |
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