The pharmacodynamic properties of lorazepam and methylphenidate drugs on event-related potentials and power spectral analysis in normal subjects
The effect of lorazepam and methylphenidate on the ERPs and power spectral analysis was studied. Lorazepam caused prolonged latency and decreased amplitude of N200 and P300. This result suggests that lorazepam affects the neural processing of cognitive function. The drowsiness induced by lorazepam c...
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| Veröffentlicht in: | Clinical EEG electroencephalography 1986-10, Vol.17 (4), p.176-180 |
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| creator | BERCHOU, R CHAYASIRISOBHON, S GREEN, V MASON, K |
| description | The effect of lorazepam and methylphenidate on the ERPs and power spectral analysis was studied. Lorazepam caused prolonged latency and decreased amplitude of N200 and P300. This result suggests that lorazepam affects the neural processing of cognitive function. The drowsiness induced by lorazepam correlated inversely with alpha frequency power, but had no direct correlation with fast activity. On the contrary, when methylphenidate was given, there was no change in ERPs. There was an increase in percent alpha frequency correlated with the alertness of the subjects. An analysis of variance involving the factors of drug and time of rating showed that subjects showed a significant (p less than 0.0001) decrease in alertness over time while receiving lorazepam, and a significant (p less than 0.05) increase in alertness over time while receiving methylphenidate. |
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Lorazepam caused prolonged latency and decreased amplitude of N200 and P300. This result suggests that lorazepam affects the neural processing of cognitive function. The drowsiness induced by lorazepam correlated inversely with alpha frequency power, but had no direct correlation with fast activity. On the contrary, when methylphenidate was given, there was no change in ERPs. There was an increase in percent alpha frequency correlated with the alertness of the subjects. An analysis of variance involving the factors of drug and time of rating showed that subjects showed a significant (p less than 0.0001) decrease in alertness over time while receiving lorazepam, and a significant (p less than 0.05) increase in alertness over time while receiving methylphenidate.</description><identifier>ISSN: 0009-9155</identifier><identifier>PMID: 3791644</identifier><language>eng</language><publisher>Pewaukee, WI: ECNS</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Cognition - physiology ; Electroencephalography ; Female ; Humans ; Lorazepam - pharmacology ; Male ; Medical sciences ; Membrane Potentials - drug effects ; Methylphenidate - pharmacology ; Middle Aged ; Neuropharmacology ; Pharmacology. Drug treatments ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. 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Lorazepam caused prolonged latency and decreased amplitude of N200 and P300. This result suggests that lorazepam affects the neural processing of cognitive function. The drowsiness induced by lorazepam correlated inversely with alpha frequency power, but had no direct correlation with fast activity. On the contrary, when methylphenidate was given, there was no change in ERPs. There was an increase in percent alpha frequency correlated with the alertness of the subjects. An analysis of variance involving the factors of drug and time of rating showed that subjects showed a significant (p less than 0.0001) decrease in alertness over time while receiving lorazepam, and a significant (p less than 0.05) increase in alertness over time while receiving methylphenidate.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cognition - physiology</subject><subject>Electroencephalography</subject><subject>Female</subject><subject>Humans</subject><subject>Lorazepam - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Potentials - drug effects</subject><subject>Methylphenidate - pharmacology</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. 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Drug treatments</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>BERCHOU, R</creatorcontrib><creatorcontrib>CHAYASIRISOBHON, S</creatorcontrib><creatorcontrib>GREEN, V</creatorcontrib><creatorcontrib>MASON, K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical EEG electroencephalography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BERCHOU, R</au><au>CHAYASIRISOBHON, S</au><au>GREEN, V</au><au>MASON, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The pharmacodynamic properties of lorazepam and methylphenidate drugs on event-related potentials and power spectral analysis in normal subjects</atitle><jtitle>Clinical EEG electroencephalography</jtitle><addtitle>Clin Electroencephalogr</addtitle><date>1986-10-01</date><risdate>1986</risdate><volume>17</volume><issue>4</issue><spage>176</spage><epage>180</epage><pages>176-180</pages><issn>0009-9155</issn><abstract>The effect of lorazepam and methylphenidate on the ERPs and power spectral analysis was studied. Lorazepam caused prolonged latency and decreased amplitude of N200 and P300. This result suggests that lorazepam affects the neural processing of cognitive function. The drowsiness induced by lorazepam correlated inversely with alpha frequency power, but had no direct correlation with fast activity. On the contrary, when methylphenidate was given, there was no change in ERPs. There was an increase in percent alpha frequency correlated with the alertness of the subjects. An analysis of variance involving the factors of drug and time of rating showed that subjects showed a significant (p less than 0.0001) decrease in alertness over time while receiving lorazepam, and a significant (p less than 0.05) increase in alertness over time while receiving methylphenidate.</abstract><cop>Pewaukee, WI</cop><pub>ECNS</pub><pmid>3791644</pmid><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Biological and medical sciences Cognition - physiology Electroencephalography Female Humans Lorazepam - pharmacology Male Medical sciences Membrane Potentials - drug effects Methylphenidate - pharmacology Middle Aged Neuropharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Time Factors |
| title | The pharmacodynamic properties of lorazepam and methylphenidate drugs on event-related potentials and power spectral analysis in normal subjects |
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