Role of the dorsomedial nucleus of the thalamus in Alzheimer's disease
It is not known whether changes in the thalamus play a role in the memory loss or dementia of Alzheimer's disease (AD), although trauma, infarction, and hemorrhage to the thalamus, particularly the dorsomedial nucleus (DMN), can cause these cognitive changes. To determine the pathologic changes...
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| Veröffentlicht in: | Journal of geriatric psychiatry and neurology 1995, Vol.8 (1), p.32-37 |
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| container_title | Journal of geriatric psychiatry and neurology |
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| creator | PASKAVITZ, J. F LIPPA, C. F HAMOS, J. E PULASKI-SALO, D DRACHMAN, D. A |
| description | It is not known whether changes in the thalamus play a role in the memory loss or dementia of Alzheimer's disease (AD), although trauma, infarction, and hemorrhage to the thalamus, particularly the dorsomedial nucleus (DMN), can cause these cognitive changes. To determine the pathologic changes in the DMN in AD, we examined the DMN in 16 cases of AD and 7 age-matched controls, with quantitative assessments of the total neuronal population and synaptic density, Alz-50-positive neurons, neurofibrillary tangles (NFT), and senile plaques (SP). We examined sections after staining with cresyl violet, a silver stain, and immunocytochemical staining for Alz-50 and synapsin I. Stereologic analysis demonstrated a mean loss of 29% of DMN neurons in AD and a synaptic density decrease of 21%. Alz-50 staining and NFT were present in all AD cases but in none of the controls. Senile plaques were 52 times more frequent in the DMN in AD than in the age-matched controls. The large variation in pathologic changes among our AD cases suggests that neuronal losses and other pathology in the DMN in AD may contribute to the total brain burden of pathology resulting in dementia in some AD patients, but not in others. |
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Alz-50 staining and NFT were present in all AD cases but in none of the controls. Senile plaques were 52 times more frequent in the DMN in AD than in the age-matched controls. The large variation in pathologic changes among our AD cases suggests that neuronal losses and other pathology in the DMN in AD may contribute to the total brain burden of pathology resulting in dementia in some AD patients, but not in others.</description><identifier>ISSN: 0891-9887</identifier><identifier>EISSN: 1552-5708</identifier><identifier>PMID: 7710644</identifier><language>eng</language><publisher>Hamilton, ON: Decker</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - pathology ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. 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E</creatorcontrib><creatorcontrib>PULASKI-SALO, D</creatorcontrib><creatorcontrib>DRACHMAN, D. A</creatorcontrib><title>Role of the dorsomedial nucleus of the thalamus in Alzheimer's disease</title><title>Journal of geriatric psychiatry and neurology</title><addtitle>J Geriatr Psychiatry Neurol</addtitle><description>It is not known whether changes in the thalamus play a role in the memory loss or dementia of Alzheimer's disease (AD), although trauma, infarction, and hemorrhage to the thalamus, particularly the dorsomedial nucleus (DMN), can cause these cognitive changes. To determine the pathologic changes in the DMN in AD, we examined the DMN in 16 cases of AD and 7 age-matched controls, with quantitative assessments of the total neuronal population and synaptic density, Alz-50-positive neurons, neurofibrillary tangles (NFT), and senile plaques (SP). We examined sections after staining with cresyl violet, a silver stain, and immunocytochemical staining for Alz-50 and synapsin I. Stereologic analysis demonstrated a mean loss of 29% of DMN neurons in AD and a synaptic density decrease of 21%. Alz-50 staining and NFT were present in all AD cases but in none of the controls. Senile plaques were 52 times more frequent in the DMN in AD than in the age-matched controls. The large variation in pathologic changes among our AD cases suggests that neuronal losses and other pathology in the DMN in AD may contribute to the total brain burden of pathology resulting in dementia in some AD patients, but not in others.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - pathology</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. 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A</creator><general>Decker</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>Role of the dorsomedial nucleus of the thalamus in Alzheimer's disease</title><author>PASKAVITZ, J. F ; LIPPA, C. F ; HAMOS, J. E ; PULASKI-SALO, D ; DRACHMAN, D. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p150t-2496d3fd6a1b267bbf4ffe54413c9671e5eccb02e9dec3f6d3df196536270c183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - pathology</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Thalamic Nuclei - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PASKAVITZ, J. F</creatorcontrib><creatorcontrib>LIPPA, C. F</creatorcontrib><creatorcontrib>HAMOS, J. E</creatorcontrib><creatorcontrib>PULASKI-SALO, D</creatorcontrib><creatorcontrib>DRACHMAN, D. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of geriatric psychiatry and neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PASKAVITZ, J. F</au><au>LIPPA, C. F</au><au>HAMOS, J. E</au><au>PULASKI-SALO, D</au><au>DRACHMAN, D. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of the dorsomedial nucleus of the thalamus in Alzheimer's disease</atitle><jtitle>Journal of geriatric psychiatry and neurology</jtitle><addtitle>J Geriatr Psychiatry Neurol</addtitle><date>1995</date><risdate>1995</risdate><volume>8</volume><issue>1</issue><spage>32</spage><epage>37</epage><pages>32-37</pages><issn>0891-9887</issn><eissn>1552-5708</eissn><abstract>It is not known whether changes in the thalamus play a role in the memory loss or dementia of Alzheimer's disease (AD), although trauma, infarction, and hemorrhage to the thalamus, particularly the dorsomedial nucleus (DMN), can cause these cognitive changes. To determine the pathologic changes in the DMN in AD, we examined the DMN in 16 cases of AD and 7 age-matched controls, with quantitative assessments of the total neuronal population and synaptic density, Alz-50-positive neurons, neurofibrillary tangles (NFT), and senile plaques (SP). We examined sections after staining with cresyl violet, a silver stain, and immunocytochemical staining for Alz-50 and synapsin I. Stereologic analysis demonstrated a mean loss of 29% of DMN neurons in AD and a synaptic density decrease of 21%. Alz-50 staining and NFT were present in all AD cases but in none of the controls. Senile plaques were 52 times more frequent in the DMN in AD than in the age-matched controls. The large variation in pathologic changes among our AD cases suggests that neuronal losses and other pathology in the DMN in AD may contribute to the total brain burden of pathology resulting in dementia in some AD patients, but not in others.</abstract><cop>Hamilton, ON</cop><pub>Decker</pub><pmid>7710644</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Journal of geriatric psychiatry and neurology, 1995, Vol.8 (1), p.32-37 |
| issn | 0891-9887 1552-5708 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77210403 |
| source | SAGE Complete A-Z List; MEDLINE |
| subjects | Aged Aged, 80 and over Alzheimer Disease - pathology Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Humans Immunoenzyme Techniques Medical sciences Middle Aged Neurology Thalamic Nuclei - pathology |
| title | Role of the dorsomedial nucleus of the thalamus in Alzheimer's disease |
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