Role of renin-angiotensin system in blood pressure regulation in pregnancy

We gave captopril (25 mg) to nine pregnant and eight non-pregnant women. From baseline to 60 min post-captopril, mean arterial pressure decreased significantly more in pregnant than in non-pregnant women (mean 15·0 [SE 2·5] vs 5·2 [1·2] mm Hg; difference 9·8 [95% Cl 3·9-15·9] mm Hg, p=0·0036), where...

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Veröffentlicht in:	The Lancet (British edition) 1995-04, Vol.345 (8954), p.896-897
Hauptverfasser:	August, P., Mueller, F.B., Sealey, J.E., Edersheim, T.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Blood pressure Blood Pressure - drug effects Blood Pressure - physiology Captopril - pharmacology Drug therapy Female Gynecology. Andrology. Obstetrics Humans Management. Prenatal diagnosis Medical research Medical sciences Pregnancy Pregnancy - physiology Pregnancy. Fetus. Placenta Renin - blood Renin-Angiotensin System - physiology
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Zusammenfassung:	We gave captopril (25 mg) to nine pregnant and eight non-pregnant women. From baseline to 60 min post-captopril, mean arterial pressure decreased significantly more in pregnant than in non-pregnant women (mean 15·0 [SE 2·5] vs 5·2 [1·2] mm Hg; difference 9·8 [95% Cl 3·9-15·9] mm Hg, p=0·0036), whereas plasma renin activity increased significantly more in the pregnant group (18·0 [5·5] vs 4·5 [1·9] ng mL -1 h -1; difference 13·5 [0·71-26·5], p=0·043). These findings support the hypothesis that stimulation of the renin-angiotensin system in pregnancy maintains blood pressure.
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(95)90012-8