The effect of instrumentation on human spinal fusion mass
This study is a prospective histomorphometric evaluation of human spinal fusion bone using video dimensional analysis. Little information exists regarding the biology of fusion mass (FM) and the effect that instrumentation has on FM quality. Concerns regarding potential for "stress shielding&qu...
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| Veröffentlicht in: | Spine (Philadelphia, Pa. 1976) Pa. 1976), 1995, Vol.20 (1), p.90-97 |
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| container_title | Spine (Philadelphia, Pa. 1976) |
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| creator | KLEINER, J. B ODOM, J. A MOORE, M. R WILSON, N. A HUFFER, W. E |
| description | This study is a prospective histomorphometric evaluation of human spinal fusion bone using video dimensional analysis.
Little information exists regarding the biology of fusion mass (FM) and the effect that instrumentation has on FM quality. Concerns regarding potential for "stress shielding" of FM with rigid implants have arisen. The goal of this study was to determine what effect spinal implants have on the quality and metabolism of FM bone.
Fifty-six patients underwent surgeries to remove spinal implants or extend a fusion after pulse-dose labeling with fluorochrome. Twelve patients had undergone fusions without instrumentation. Duplicate biopsies of FM and iliac crest (IC) were obtained and evaluated blindly for mineralized volume, trabecular thickness, mineralization rate, and bone formation rate. Iliac crest, instrumented FM, and noninstrumented FM were compared.
Instrumental FM had superior material properties relative to noninstrumented FM or IC. No significant difference in metabolic activity was present.
Instrumentation does not lead to FM "stress-shielding." |
| doi_str_mv | 10.1097/00007632-199501000-00016 |
| format | Article |
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Little information exists regarding the biology of fusion mass (FM) and the effect that instrumentation has on FM quality. Concerns regarding potential for "stress shielding" of FM with rigid implants have arisen. The goal of this study was to determine what effect spinal implants have on the quality and metabolism of FM bone.
Fifty-six patients underwent surgeries to remove spinal implants or extend a fusion after pulse-dose labeling with fluorochrome. Twelve patients had undergone fusions without instrumentation. Duplicate biopsies of FM and iliac crest (IC) were obtained and evaluated blindly for mineralized volume, trabecular thickness, mineralization rate, and bone formation rate. Iliac crest, instrumented FM, and noninstrumented FM were compared.
Instrumental FM had superior material properties relative to noninstrumented FM or IC. No significant difference in metabolic activity was present.
Instrumentation does not lead to FM "stress-shielding."</description><identifier>ISSN: 0362-2436</identifier><identifier>EISSN: 1528-1159</identifier><identifier>DOI: 10.1097/00007632-199501000-00016</identifier><identifier>PMID: 7709285</identifier><identifier>CODEN: SPINDD</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott</publisher><subject>Adolescent ; Adult ; Aged ; Analysis of Variance ; Biological and medical sciences ; Biopsy ; Calcification, Physiologic ; Female ; Humans ; Lumbar Vertebrae - diagnostic imaging ; Lumbar Vertebrae - pathology ; Lumbar Vertebrae - surgery ; Male ; Medical sciences ; Middle Aged ; Orthopedic surgery ; Prospective Studies ; Radiography ; Space life sciences ; Spinal Fusion - adverse effects ; Spinal Fusion - instrumentation ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Thoracic Vertebrae - diagnostic imaging ; Thoracic Vertebrae - pathology ; Thoracic Vertebrae - surgery</subject><ispartof>Spine (Philadelphia, Pa. 1976), 1995, Vol.20 (1), p.90-97</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-a3ab2963db359e6c3ac599b7077d9b0abee395421f3cfa7d363d47cd33a726ad3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3404240$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7709285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KLEINER, J. B</creatorcontrib><creatorcontrib>ODOM, J. A</creatorcontrib><creatorcontrib>MOORE, M. R</creatorcontrib><creatorcontrib>WILSON, N. A</creatorcontrib><creatorcontrib>HUFFER, W. E</creatorcontrib><title>The effect of instrumentation on human spinal fusion mass</title><title>Spine (Philadelphia, Pa. 1976)</title><addtitle>Spine (Phila Pa 1976)</addtitle><description>This study is a prospective histomorphometric evaluation of human spinal fusion bone using video dimensional analysis.
Little information exists regarding the biology of fusion mass (FM) and the effect that instrumentation has on FM quality. Concerns regarding potential for "stress shielding" of FM with rigid implants have arisen. The goal of this study was to determine what effect spinal implants have on the quality and metabolism of FM bone.
Fifty-six patients underwent surgeries to remove spinal implants or extend a fusion after pulse-dose labeling with fluorochrome. Twelve patients had undergone fusions without instrumentation. Duplicate biopsies of FM and iliac crest (IC) were obtained and evaluated blindly for mineralized volume, trabecular thickness, mineralization rate, and bone formation rate. Iliac crest, instrumented FM, and noninstrumented FM were compared.
Instrumental FM had superior material properties relative to noninstrumented FM or IC. No significant difference in metabolic activity was present.
Instrumentation does not lead to FM "stress-shielding."</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Calcification, Physiologic</subject><subject>Female</subject><subject>Humans</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Lumbar Vertebrae - pathology</subject><subject>Lumbar Vertebrae - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Orthopedic surgery</subject><subject>Prospective Studies</subject><subject>Radiography</subject><subject>Space life sciences</subject><subject>Spinal Fusion - adverse effects</subject><subject>Spinal Fusion - instrumentation</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Thoracic Vertebrae - diagnostic imaging</subject><subject>Thoracic Vertebrae - pathology</subject><subject>Thoracic Vertebrae - surgery</subject><issn>0362-2436</issn><issn>1528-1159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLAzEQgIMotVZ_grAH8baaZPJojlJ8QcFLPYfZbEJX9uVm9-C_N7VrhwxDMt9M4CMkY_SBUaMfaQqtgOfMGElZuuUpmTojSyb5OmdMmnOypKB4zgWoS3IV41dCFDCzIAutqeFruSRmt_eZD8G7MetCVrVxHKbGtyOOVddm6eynBtss9lWLdRameHhuMMZrchGwjv5mrivy-fK827zl24_X983TNncCxJgjYMGNgrIAabxygE4aU2iqdWkKioX3YKTgLIALqEtIqNCuBEDNFZawIvfHvf3QfU8-jrapovN1ja3vpmi15lRJ4AlcH0E3dDEOPth-qBocfiyj9mDN_luzJ2v2z1oavZ3_mIrGl6fBWVPq3819jA7rMGDrqnjCQFDBBYVf8TJ0EA</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>KLEINER, J. B</creator><creator>ODOM, J. A</creator><creator>MOORE, M. R</creator><creator>WILSON, N. A</creator><creator>HUFFER, W. E</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>The effect of instrumentation on human spinal fusion mass</title><author>KLEINER, J. B ; ODOM, J. A ; MOORE, M. R ; WILSON, N. A ; HUFFER, W. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-a3ab2963db359e6c3ac599b7077d9b0abee395421f3cfa7d363d47cd33a726ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Calcification, Physiologic</topic><topic>Female</topic><topic>Humans</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Lumbar Vertebrae - pathology</topic><topic>Lumbar Vertebrae - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Orthopedic surgery</topic><topic>Prospective Studies</topic><topic>Radiography</topic><topic>Space life sciences</topic><topic>Spinal Fusion - adverse effects</topic><topic>Spinal Fusion - instrumentation</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Thoracic Vertebrae - diagnostic imaging</topic><topic>Thoracic Vertebrae - pathology</topic><topic>Thoracic Vertebrae - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KLEINER, J. B</creatorcontrib><creatorcontrib>ODOM, J. A</creatorcontrib><creatorcontrib>MOORE, M. R</creatorcontrib><creatorcontrib>WILSON, N. A</creatorcontrib><creatorcontrib>HUFFER, W. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KLEINER, J. B</au><au>ODOM, J. A</au><au>MOORE, M. R</au><au>WILSON, N. A</au><au>HUFFER, W. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of instrumentation on human spinal fusion mass</atitle><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle><addtitle>Spine (Phila Pa 1976)</addtitle><date>1995</date><risdate>1995</risdate><volume>20</volume><issue>1</issue><spage>90</spage><epage>97</epage><pages>90-97</pages><issn>0362-2436</issn><eissn>1528-1159</eissn><coden>SPINDD</coden><abstract>This study is a prospective histomorphometric evaluation of human spinal fusion bone using video dimensional analysis.
Little information exists regarding the biology of fusion mass (FM) and the effect that instrumentation has on FM quality. Concerns regarding potential for "stress shielding" of FM with rigid implants have arisen. The goal of this study was to determine what effect spinal implants have on the quality and metabolism of FM bone.
Fifty-six patients underwent surgeries to remove spinal implants or extend a fusion after pulse-dose labeling with fluorochrome. Twelve patients had undergone fusions without instrumentation. Duplicate biopsies of FM and iliac crest (IC) were obtained and evaluated blindly for mineralized volume, trabecular thickness, mineralization rate, and bone formation rate. Iliac crest, instrumented FM, and noninstrumented FM were compared.
Instrumental FM had superior material properties relative to noninstrumented FM or IC. No significant difference in metabolic activity was present.
Instrumentation does not lead to FM "stress-shielding."</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>7709285</pmid><doi>10.1097/00007632-199501000-00016</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0362-2436 |
| ispartof | Spine (Philadelphia, Pa. 1976), 1995, Vol.20 (1), p.90-97 |
| issn | 0362-2436 1528-1159 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Aged Analysis of Variance Biological and medical sciences Biopsy Calcification, Physiologic Female Humans Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - pathology Lumbar Vertebrae - surgery Male Medical sciences Middle Aged Orthopedic surgery Prospective Studies Radiography Space life sciences Spinal Fusion - adverse effects Spinal Fusion - instrumentation Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Thoracic Vertebrae - diagnostic imaging Thoracic Vertebrae - pathology Thoracic Vertebrae - surgery |
| title | The effect of instrumentation on human spinal fusion mass |
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