Effect of low-dose cyclosporin on plasma lipoproteins and markers of cholestasis in patients with psoriasis
The benefits of using cyclosporin in organ transplantation to prevent graft rejection outweigh its potential disadvantages, but with the use of lowdose cyclosporin in relatively healthy individuals, such as those with psoriasis, the risk:benefit ratio is altered. The effects of low-dose cyclosporin...
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| Veröffentlicht in: | QJM : An International Journal of Medicine 1995-02, Vol.88 (2), p.109-113 |
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| container_title | QJM : An International Journal of Medicine |
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| creator | EDWARDS, B.D. BHATNAGAR, D. MACKNESS, M.I. GOKAL, R. BALLARDIE, F.W. CHALMERS, R.J.G. DURRINGTON, P.N. |
| description | The benefits of using cyclosporin in organ transplantation to prevent graft rejection outweigh its potential disadvantages, but with the use of lowdose cyclosporin in relatively healthy individuals, such as those with psoriasis, the risk:benefit ratio is altered. The effects of low-dose cyclosporin ( |
| doi_str_mv | 10.1093/oxfordjournals.qjmed.a069031 |
| format | Article |
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The effects of low-dose cyclosporin (<5 mg/kg body weight) on liver function and serum lipids and lipoproteins were examined in 40 normolipidaemic, normotensive psoriasis patients with normal renal function. After 3 months of treatment, serum cholesterol and bilirubin concentrations and alkaline phosphatase activity increased significantly (p = 0.001), and glomerular filtration rate (GFR) declined from 107 to 96 ml/min/1.73 m2 (p = 0.05). All these values returned to pretreatment levels 3 months after cessation of cyclosporin. In 15 patients in whom lipoproteins were isolated by ultracentrifugation, there was an increase in plasma low-density lipoprotein (LDL) cholesterol (p=0.05), but very-low-density lipoprotein cholesterol, high-density lipoprotein (HDL) and HDL2 and HDL3 cholesterol concentrations did not change. The increases in serum bilirubin, alkaline phosphatase activity and LDL cholesterol, seen in individuals with normal baseline liver and renal function, which reverted to baseline following cessation of cyclosporin, suggest that cyclosporininduced hypercholesterolaemia may be due to either decreased biliary excretion of cholesterol or impaired catabolism of LDL.</description><identifier>ISSN: 0033-5614</identifier><identifier>ISSN: 1460-2725</identifier><identifier>ISSN: 1460-2393</identifier><identifier>EISSN: 1464-3855</identifier><identifier>EISSN: 1460-2393</identifier><identifier>DOI: 10.1093/oxfordjournals.qjmed.a069031</identifier><identifier>PMID: 7704561</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Biomarkers - blood ; Cholestasis - blood ; Cholesterol, LDL - blood ; Cyclosporine - administration & dosage ; Cyclosporine - therapeutic use ; Drug Administration Schedule ; Humans ; Lipoproteins - blood ; Liver Function Tests ; Psoriasis - blood ; Psoriasis - drug therapy</subject><ispartof>QJM : An International Journal of Medicine, 1995-02, Vol.88 (2), p.109-113</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7704561$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>EDWARDS, B.D.</creatorcontrib><creatorcontrib>BHATNAGAR, D.</creatorcontrib><creatorcontrib>MACKNESS, M.I.</creatorcontrib><creatorcontrib>GOKAL, R.</creatorcontrib><creatorcontrib>BALLARDIE, F.W.</creatorcontrib><creatorcontrib>CHALMERS, R.J.G.</creatorcontrib><creatorcontrib>DURRINGTON, P.N.</creatorcontrib><title>Effect of low-dose cyclosporin on plasma lipoproteins and markers of cholestasis in patients with psoriasis</title><title>QJM : An International Journal of Medicine</title><addtitle>QJM</addtitle><description>The benefits of using cyclosporin in organ transplantation to prevent graft rejection outweigh its potential disadvantages, but with the use of lowdose cyclosporin in relatively healthy individuals, such as those with psoriasis, the risk:benefit ratio is altered. The effects of low-dose cyclosporin (<5 mg/kg body weight) on liver function and serum lipids and lipoproteins were examined in 40 normolipidaemic, normotensive psoriasis patients with normal renal function. After 3 months of treatment, serum cholesterol and bilirubin concentrations and alkaline phosphatase activity increased significantly (p = 0.001), and glomerular filtration rate (GFR) declined from 107 to 96 ml/min/1.73 m2 (p = 0.05). All these values returned to pretreatment levels 3 months after cessation of cyclosporin. In 15 patients in whom lipoproteins were isolated by ultracentrifugation, there was an increase in plasma low-density lipoprotein (LDL) cholesterol (p=0.05), but very-low-density lipoprotein cholesterol, high-density lipoprotein (HDL) and HDL2 and HDL3 cholesterol concentrations did not change. The increases in serum bilirubin, alkaline phosphatase activity and LDL cholesterol, seen in individuals with normal baseline liver and renal function, which reverted to baseline following cessation of cyclosporin, suggest that cyclosporininduced hypercholesterolaemia may be due to either decreased biliary excretion of cholesterol or impaired catabolism of LDL.</description><subject>Biomarkers - blood</subject><subject>Cholestasis - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Cyclosporine - administration & dosage</subject><subject>Cyclosporine - therapeutic use</subject><subject>Drug Administration Schedule</subject><subject>Humans</subject><subject>Lipoproteins - blood</subject><subject>Liver Function Tests</subject><subject>Psoriasis - blood</subject><subject>Psoriasis - drug therapy</subject><issn>0033-5614</issn><issn>1460-2725</issn><issn>1460-2393</issn><issn>1464-3855</issn><issn>1460-2393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1r3DAQhkVpSTcfP6GgQ-nNW8kjSzL0kiz5aLPQSwIhFyHLMtHGazkaL9n8-2i720JPA_POO_POQ8hXzuac1fA9bruY2lXcpMH2OH9ZrX07t0zWDPgHMuNCigJ0VX0kM8YAikpy8ZkcI64YY0JoeUSOlGIi92fk-bLrvJto7GgfX4s2oqfuzfURx5jCQONAx97i2tI-jHFMcfJhQGqHlq5tevYJd1b3FHuPk8WANJtGOwU_TEhfw_RER8ybdtIp-dTlxP7sUE_I_dXl3eKmWP6-_rk4Xxau5OVUaOmAS1np0mruStnwWjrRKIDWKt_I0qusQ8srzWpeA4NKQqU817wRSns4Id_2e3Pcl03OZdYBne97O_i4QaNUyQRAmQd_7AddiojJd2ZMIb_1ZjgzO9bmf9bmD2tzYJ3tXw53Ns2u_9d8gJv1Yq8HnPz2n5yxGalAVebm4dEs-K2-XVz8MgDvEMGSPA</recordid><startdate>199502</startdate><enddate>199502</enddate><creator>EDWARDS, B.D.</creator><creator>BHATNAGAR, D.</creator><creator>MACKNESS, M.I.</creator><creator>GOKAL, R.</creator><creator>BALLARDIE, F.W.</creator><creator>CHALMERS, R.J.G.</creator><creator>DURRINGTON, P.N.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199502</creationdate><title>Effect of low-dose cyclosporin on plasma lipoproteins and markers of cholestasis in patients with psoriasis</title><author>EDWARDS, B.D. ; BHATNAGAR, D. ; MACKNESS, M.I. ; GOKAL, R. ; BALLARDIE, F.W. ; CHALMERS, R.J.G. ; DURRINGTON, P.N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c212t-86c3166582a81c26b196c4b733da7eb62e73163d158091930356357e181b478e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Biomarkers - blood</topic><topic>Cholestasis - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Cyclosporine - administration & dosage</topic><topic>Cyclosporine - therapeutic use</topic><topic>Drug Administration Schedule</topic><topic>Humans</topic><topic>Lipoproteins - blood</topic><topic>Liver Function Tests</topic><topic>Psoriasis - blood</topic><topic>Psoriasis - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>EDWARDS, B.D.</creatorcontrib><creatorcontrib>BHATNAGAR, D.</creatorcontrib><creatorcontrib>MACKNESS, M.I.</creatorcontrib><creatorcontrib>GOKAL, R.</creatorcontrib><creatorcontrib>BALLARDIE, F.W.</creatorcontrib><creatorcontrib>CHALMERS, R.J.G.</creatorcontrib><creatorcontrib>DURRINGTON, P.N.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>QJM : An International Journal of Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>EDWARDS, B.D.</au><au>BHATNAGAR, D.</au><au>MACKNESS, M.I.</au><au>GOKAL, R.</au><au>BALLARDIE, F.W.</au><au>CHALMERS, R.J.G.</au><au>DURRINGTON, P.N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of low-dose cyclosporin on plasma lipoproteins and markers of cholestasis in patients with psoriasis</atitle><jtitle>QJM : An International Journal of Medicine</jtitle><addtitle>QJM</addtitle><date>1995-02</date><risdate>1995</risdate><volume>88</volume><issue>2</issue><spage>109</spage><epage>113</epage><pages>109-113</pages><issn>0033-5614</issn><issn>1460-2725</issn><issn>1460-2393</issn><eissn>1464-3855</eissn><eissn>1460-2393</eissn><abstract>The benefits of using cyclosporin in organ transplantation to prevent graft rejection outweigh its potential disadvantages, but with the use of lowdose cyclosporin in relatively healthy individuals, such as those with psoriasis, the risk:benefit ratio is altered. The effects of low-dose cyclosporin (<5 mg/kg body weight) on liver function and serum lipids and lipoproteins were examined in 40 normolipidaemic, normotensive psoriasis patients with normal renal function. After 3 months of treatment, serum cholesterol and bilirubin concentrations and alkaline phosphatase activity increased significantly (p = 0.001), and glomerular filtration rate (GFR) declined from 107 to 96 ml/min/1.73 m2 (p = 0.05). All these values returned to pretreatment levels 3 months after cessation of cyclosporin. In 15 patients in whom lipoproteins were isolated by ultracentrifugation, there was an increase in plasma low-density lipoprotein (LDL) cholesterol (p=0.05), but very-low-density lipoprotein cholesterol, high-density lipoprotein (HDL) and HDL2 and HDL3 cholesterol concentrations did not change. The increases in serum bilirubin, alkaline phosphatase activity and LDL cholesterol, seen in individuals with normal baseline liver and renal function, which reverted to baseline following cessation of cyclosporin, suggest that cyclosporininduced hypercholesterolaemia may be due to either decreased biliary excretion of cholesterol or impaired catabolism of LDL.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>7704561</pmid><doi>10.1093/oxfordjournals.qjmed.a069031</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Biomarkers - blood Cholestasis - blood Cholesterol, LDL - blood Cyclosporine - administration & dosage Cyclosporine - therapeutic use Drug Administration Schedule Humans Lipoproteins - blood Liver Function Tests Psoriasis - blood Psoriasis - drug therapy |
| title | Effect of low-dose cyclosporin on plasma lipoproteins and markers of cholestasis in patients with psoriasis |
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