In vitro pharmacology of ACEA-1021 and ACEA-1031: systemically active quinoxalinediones with high affinity and selectivity for N-methyl-D-aspartate receptor glycine sites

N-methyl-D-aspartate (NMDA) receptor antagonists show therapeutic potential as neuroprotectants, analgesics, and anticonvulsants. In this context, we used electrical recording techniques to study the in vitro pharmacology of two novel quinoxalinediones, i.e., ACEA-1021 and ACEA-1031 (5-nitro-6,7- di...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular pharmacology 1995-03, Vol.47 (3), p.568-581
Hauptverfasser:	Woodward, R M, Huettner, J E, Guastella, J, Keana, J F, Weber, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Brain - drug effects Brain - metabolism Brain - physiology Cells, Cultured Cloning, Molecular DNA, Complementary - genetics Electrophysiology Female Glycine - metabolism Kynurenic Acid - analogs & derivatives Kynurenic Acid - pharmacology Neurons - drug effects Neurons - metabolism Neurons - physiology Oocytes - drug effects Oocytes - physiology Oocytes - ultrastructure Quinoxalines - metabolism Quinoxalines - pharmacology Rats Receptors, Glutamate - drug effects Receptors, Glutamate - genetics Receptors, Glutamate - metabolism Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism RNA, Complementary - genetics RNA, Messenger - genetics Transcription, Genetic Xenopus laevis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!