Bronchiolitis Obliterans in Single-Lung Transplant Recipients
The presentation and clinical course of bronchiolitis obliterans (BO) in single-lung transplant (SLT) recipients has thus far not been well described. We retrospectively analyzed the serial spirometry of 15 SLT patients with BO. All the patients fulfilled the criteria for BO syndrome, and 11 of the...
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| Veröffentlicht in: | Chest 1995-04, Vol.107 (4), p.967-972 |
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| creator | Nathan, Steven D. Ross, David J. Belman, Michael J. Shain, Sara Elashoff, Janet D. Kass, Robert M. Koerner, Spencer K. |
| description | The presentation and clinical course of bronchiolitis obliterans (BO) in single-lung transplant (SLT) recipients has thus far not been well described. We retrospectively analyzed the serial spirometry of 15 SLT patients with BO. All the patients fulfilled the criteria for BO syndrome, and 11 of the 15 had histologically documented BO. Based on serial FEV1 analysis, we identified three patterns of presentation and progression of BO. The first pattern (n=6) was characterized by a rapid onset and a relentless progressive course; the second pattern (n=5) was characterized by a similar rapid onset and initial rapid decline, but was followed by stabilization in lung function; the third pattern (n=4) was characterized by an insidious onset and course. In all patients, a permanent reduction in the mean forced expiratory flow during the middle half of the forced vital capacity appeared to be an early sensitive index for the development of BO. An appreciation of these different modes of presentation and progression of BO is potentially important in the assessment of prognosis and management of the SLT recipient. |
| doi_str_mv | 10.1378/chest.107.4.967 |
| format | Article |
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We retrospectively analyzed the serial spirometry of 15 SLT patients with BO. All the patients fulfilled the criteria for BO syndrome, and 11 of the 15 had histologically documented BO. Based on serial FEV1 analysis, we identified three patterns of presentation and progression of BO. The first pattern (n=6) was characterized by a rapid onset and a relentless progressive course; the second pattern (n=5) was characterized by a similar rapid onset and initial rapid decline, but was followed by stabilization in lung function; the third pattern (n=4) was characterized by an insidious onset and course. In all patients, a permanent reduction in the mean forced expiratory flow during the middle half of the forced vital capacity appeared to be an early sensitive index for the development of BO. An appreciation of these different modes of presentation and progression of BO is potentially important in the assessment of prognosis and management of the SLT recipient.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.107.4.967</identifier><identifier>PMID: 7705163</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Bronchiolitis ; bronchiolitis obliterans ; Bronchiolitis Obliterans - etiology ; Bronchiolitis Obliterans - physiopathology ; chronic rejection ; Complications and side effects ; Forced Expiratory Flow Rates ; Forced Expiratory Volume ; Humans ; Lung Diseases - surgery ; lung transplantation ; Lung Transplantation - adverse effects ; Lungs ; Medical sciences ; Retrospective Studies ; Risk factors ; Spirometry ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the respiratory system ; Transplantation ; Transplantation of organs, tissues, etc</subject><ispartof>Chest, 1995-04, Vol.107 (4), p.967-972</ispartof><rights>1995 The American College of Chest Physicians</rights><rights>1995 INIST-CNRS</rights><rights>COPYRIGHT 1995 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-c1f9ecd45570142ee4877eafa4c1f3c63cfd25aa957e650b9934720751be57563</citedby><cites>FETCH-LOGICAL-c486t-c1f9ecd45570142ee4877eafa4c1f3c63cfd25aa957e650b9934720751be57563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3513744$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7705163$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nathan, Steven D.</creatorcontrib><creatorcontrib>Ross, David J.</creatorcontrib><creatorcontrib>Belman, Michael J.</creatorcontrib><creatorcontrib>Shain, Sara</creatorcontrib><creatorcontrib>Elashoff, Janet D.</creatorcontrib><creatorcontrib>Kass, Robert M.</creatorcontrib><creatorcontrib>Koerner, Spencer K.</creatorcontrib><title>Bronchiolitis Obliterans in Single-Lung Transplant Recipients</title><title>Chest</title><addtitle>Chest</addtitle><description>The presentation and clinical course of bronchiolitis obliterans (BO) in single-lung transplant (SLT) recipients has thus far not been well described. We retrospectively analyzed the serial spirometry of 15 SLT patients with BO. All the patients fulfilled the criteria for BO syndrome, and 11 of the 15 had histologically documented BO. Based on serial FEV1 analysis, we identified three patterns of presentation and progression of BO. The first pattern (n=6) was characterized by a rapid onset and a relentless progressive course; the second pattern (n=5) was characterized by a similar rapid onset and initial rapid decline, but was followed by stabilization in lung function; the third pattern (n=4) was characterized by an insidious onset and course. In all patients, a permanent reduction in the mean forced expiratory flow during the middle half of the forced vital capacity appeared to be an early sensitive index for the development of BO. An appreciation of these different modes of presentation and progression of BO is potentially important in the assessment of prognosis and management of the SLT recipient.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Bronchiolitis</subject><subject>bronchiolitis obliterans</subject><subject>Bronchiolitis Obliterans - etiology</subject><subject>Bronchiolitis Obliterans - physiopathology</subject><subject>chronic rejection</subject><subject>Complications and side effects</subject><subject>Forced Expiratory Flow Rates</subject><subject>Forced Expiratory Volume</subject><subject>Humans</subject><subject>Lung Diseases - surgery</subject><subject>lung transplantation</subject><subject>Lung Transplantation - adverse effects</subject><subject>Lungs</subject><subject>Medical sciences</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Spirometry</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the respiratory system</subject><subject>Transplantation</subject><subject>Transplantation of organs, tissues, etc</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAQhi1EVZbCmRNSDogT2drxV3LgUCpaKq1UqS1ny-tMsq4cZ7GTIv49U7IqHIp8GM3MM19-CXnH6JpxXZ-6HeRpzahei3Wj9AuyYg1nJZeCvyQrSllVctVUr8jrnO8p-qxRx-RYayqZ4ivy-Usao9v5MfjJ5-J6ixaSjbnwsbj1sQ9QbubYF3ePwX2wcSpuwPm9hzjlN-SosyHD24M9Id8vvt6dfys315dX52eb0olaTaVjXQOuFVJqykQFIGqtwXZWYIY7xV3XVtLaRmpQkm6bhgtdUS3ZFqSWip-Qj0vffRp_zHixGXx2EHAdGOdsNNJMM4bgpwXsbQDjYzdOyboeIt4Uxgidx_AZU7VUNaOIl8_g-FoYvHuOP114l8acE3Rmn_xg0y_DqHnUw_zRAz1thEE9sOL9YfN5O0D7xB8EwPyHQ95mZ0OHv-x8fsK4xK5C_B288_3up09g8mBDwKZ8GXk_zina8O_gZqkA1OXBQzLZoWYOWqx2k2lH_9-lfwPnzbd7</recordid><startdate>19950401</startdate><enddate>19950401</enddate><creator>Nathan, Steven D.</creator><creator>Ross, David J.</creator><creator>Belman, Michael J.</creator><creator>Shain, Sara</creator><creator>Elashoff, Janet D.</creator><creator>Kass, Robert M.</creator><creator>Koerner, Spencer K.</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><general>Elsevier B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950401</creationdate><title>Bronchiolitis Obliterans in Single-Lung Transplant Recipients</title><author>Nathan, Steven D. ; Ross, David J. ; Belman, Michael J. ; Shain, Sara ; Elashoff, Janet D. ; Kass, Robert M. ; Koerner, Spencer K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-c1f9ecd45570142ee4877eafa4c1f3c63cfd25aa957e650b9934720751be57563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Bronchiolitis</topic><topic>bronchiolitis obliterans</topic><topic>Bronchiolitis Obliterans - etiology</topic><topic>Bronchiolitis Obliterans - physiopathology</topic><topic>chronic rejection</topic><topic>Complications and side effects</topic><topic>Forced Expiratory Flow Rates</topic><topic>Forced Expiratory Volume</topic><topic>Humans</topic><topic>Lung Diseases - surgery</topic><topic>lung transplantation</topic><topic>Lung Transplantation - adverse effects</topic><topic>Lungs</topic><topic>Medical sciences</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>Spirometry</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the respiratory system</topic><topic>Transplantation</topic><topic>Transplantation of organs, tissues, etc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nathan, Steven D.</creatorcontrib><creatorcontrib>Ross, David J.</creatorcontrib><creatorcontrib>Belman, Michael J.</creatorcontrib><creatorcontrib>Shain, Sara</creatorcontrib><creatorcontrib>Elashoff, Janet D.</creatorcontrib><creatorcontrib>Kass, Robert M.</creatorcontrib><creatorcontrib>Koerner, Spencer K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nathan, Steven D.</au><au>Ross, David J.</au><au>Belman, Michael J.</au><au>Shain, Sara</au><au>Elashoff, Janet D.</au><au>Kass, Robert M.</au><au>Koerner, Spencer K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bronchiolitis Obliterans in Single-Lung Transplant Recipients</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1995-04-01</date><risdate>1995</risdate><volume>107</volume><issue>4</issue><spage>967</spage><epage>972</epage><pages>967-972</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>The presentation and clinical course of bronchiolitis obliterans (BO) in single-lung transplant (SLT) recipients has thus far not been well described. We retrospectively analyzed the serial spirometry of 15 SLT patients with BO. All the patients fulfilled the criteria for BO syndrome, and 11 of the 15 had histologically documented BO. Based on serial FEV1 analysis, we identified three patterns of presentation and progression of BO. The first pattern (n=6) was characterized by a rapid onset and a relentless progressive course; the second pattern (n=5) was characterized by a similar rapid onset and initial rapid decline, but was followed by stabilization in lung function; the third pattern (n=4) was characterized by an insidious onset and course. In all patients, a permanent reduction in the mean forced expiratory flow during the middle half of the forced vital capacity appeared to be an early sensitive index for the development of BO. An appreciation of these different modes of presentation and progression of BO is potentially important in the assessment of prognosis and management of the SLT recipient.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>7705163</pmid><doi>10.1378/chest.107.4.967</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Bronchiolitis bronchiolitis obliterans Bronchiolitis Obliterans - etiology Bronchiolitis Obliterans - physiopathology chronic rejection Complications and side effects Forced Expiratory Flow Rates Forced Expiratory Volume Humans Lung Diseases - surgery lung transplantation Lung Transplantation - adverse effects Lungs Medical sciences Retrospective Studies Risk factors Spirometry Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the respiratory system Transplantation Transplantation of organs, tissues, etc |
| title | Bronchiolitis Obliterans in Single-Lung Transplant Recipients |
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