Protection of Dogs from Lyme Disease with a Vaccine Containing Outer Surface Protein (Osp) A, OspB, and the Saponin Adjuvant QS21

A vaccine consisting of purified Escherichia coli-expressed recombinant full-length outer surface proteins A (OspA) and B (OspB) and the saponin adjuvant QS21 was evaluated for protection against Borrelia burgdorferi infection. Eleven beagles were vaccinated twice and then challenged with 10 field-c...

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Veröffentlicht in:	The Journal of infectious diseases 1995-04, Vol.171 (4), p.1049-1052
Hauptverfasser:	Coughlin, Richard T., Fish, Durland, Mather, Thomas N., Ma, Jianneng, Pavia, Charles, Bulger, Patrice
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Animals Antibodies Antibodies, Bacterial - biosynthesis Antibodies, Bacterial - blood Antigens, Bacterial Antigens, Surface - immunology Bacterial Outer Membrane Proteins - immunology Bacterial Vaccines - immunology Borrelia burgdorferi Borrelia burgdorferi Group - immunology Borrelia burgdorferi Group - isolation & purification Concise Communication Dogs Female Immunoglobulin G - biosynthesis Immunoglobulin G - blood Infections Lethargy Lipoproteins Lyme disease Lyme Disease - prevention & control Male Saponins - immunology Spirochaetales Symptoms Ticks Ticks - microbiology Vaccination Vaccines, Synthetic - immunology Xenodiagnosis
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