A Nitro Analogue of Staurosporine and Other Minor Metabolites Produced by a Streptomyces longisporoflavus Strain

From the staurosporine-producing strain Streptomyces longisporoflavus R-19 various minor metabolites were isolated: They include a new compound with a nitro function in C-4' and other metabolites related to Staurosporine. The new structures were elucidated by spectroscopic methods, mainly 1H NM...

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Veröffentlicht in:	Journal of antibiotics 1995/02/25, Vol.48(2), pp.143-148
Hauptverfasser:	CAI, YANG, FREDENHAGEN, ANDREAS, HUG, PAUL, PETER, HEINRICH H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemistry Alkaloids - metabolism Alkaloids - pharmacology Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Chemotherapic agents Fundamental and applied biological sciences. Psychology Magnetic Resonance Spectroscopy Microbiology Molecular Structure Nitrogen Compounds - chemistry Nitrogen Compounds - isolation & purification Protein Kinase C - antagonists & inhibitors Spectrometry, Mass, Fast Atom Bombardment Staurosporine Streptomyces - metabolism
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Zusammenfassung:	From the staurosporine-producing strain Streptomyces longisporoflavus R-19 various minor metabolites were isolated: They include a new compound with a nitro function in C-4' and other metabolites related to Staurosporine. The new structures were elucidated by spectroscopic methods, mainly 1H NMR and 13C NMR and by comparison with TAN-1030A. The new compounds inhibited protein kinase C with IC50 values in the nanomolar range.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.48.143