Inactivation of plasminogen activator inhibitor by oxidants

The rapidly acting plasminogen activator inhibitor (PAI) purified from cultured bovine aortic endothelial cells (BAEs) was inactivated during iodination with chloramine T and other oxidizing iodination systems. Inactivation was observed in the absence of iodine, suggesting that the loss of activity...

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Veröffentlicht in:	Biochemistry (Easton) 1986-10, Vol.25 (21), p.6351-6355
Hauptverfasser:	Lawrence, Daniel A, Loskutoff, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques AMINES AMINO ACIDS ANIMAL TISSUES Animals aorta Aorta - metabolism BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES Biological and medical sciences Blood coagulation. Blood cells BODY CARBOXYLIC ACIDS Cattle CELL CULTURES Cells, Cultured CHEMICAL REACTIONS chloramine T CHLORAMINES Chloramines - pharmacology COAGULANTS DAYS LIVING RADIOISOTOPES DECOMPOSITION DRUGS ELECTRON CAPTURE RADIOISOTOPES ENDOTHELIUM Endothelium - metabolism ENZYMATIC HYDROLYSIS ENZYME INHIBITORS ENZYMES FIBRIN FIBRINOLYTIC AGENTS Fundamental and applied biological sciences. Psychology General aspects, investigation methods, hemostasis, fibrinolysis Glycoproteins - antagonists & inhibitors Glycoproteins - isolation & purification HALOGENATION HEMATOLOGIC AGENTS HEMOSTATICS HYDROLYSIS INACTIVATION INTERMEDIATE MASS NUCLEI IODINATION IODINE 125 IODINE ISOTOPES ISOTOPES Kinetics LABELLED COMPOUNDS LIPOTROPIC FACTORS LYSIS METHIONINE Molecular and cellular biology NUCLEI ODD-EVEN NUCLEI ORGANIC ACIDS ORGANIC CHLORINE COMPOUNDS ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS ORGANIC SULFUR COMPOUNDS OXIDATION Oxidation-Reduction OXIDIZERS OXIDOREDUCTASES PLASMINOGEN plasminogen activator inhibitor Plasminogen Activators - antagonists & inhibitors Plasminogen Inactivators PROTEINS RADIOISOTOPES SCLEROPROTEINS SOLVOLYSIS TISSUES Tosyl Compounds
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