Plasma fibronectin in liver cirrhosis and its diagnostic value
Plasma fibronectin (FN) has been measured by immunonephelometric method in 100 cirrhotic patients and compared with that of 77 normal subjects and with that of 57 patients suffering from liver disorders different from cirrhosis. Both, compensated and decompensated cirrhotics had lower plasma FN than...
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| Veröffentlicht in: | Clinica chimica acta 1986-11, Vol.160 (3), p.289-296 |
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| container_title | Clinica chimica acta |
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| creator | Gabrielli, Giovanni B. Casaril, Massimo Bonazzi, Luisa Baracchino, Fiorenza Bellisola, Giuseppe Corrocher, Roberto |
| description | Plasma fibronectin (FN) has been measured by immunonephelometric method in 100 cirrhotic patients and compared with that of 77 normal subjects and with that of 57 patients suffering from liver disorders different from cirrhosis. Both, compensated and decompensated cirrhotics had lower plasma FN than controls (31.14 ± 11.42 and 20.88 ± 10.43 respectively vs 40.13 ± 8.58 mg/dl;
p < 0.02 and
p |
| doi_str_mv | 10.1016/0009-8981(86)90196-8 |
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p < 0.02 and
p <0.001). FN in ascitic patients was lower than in non-ascitic (
p < 0.001). These differences were not due to different weight or age of patients. It appears, therefore, that FN parallels in cirrhosis the grade of liver function impairment. No significant difference has been noted between plasma FN of patients with liver diseases different from cirrhosis and control subjects. In cirrhosis, a positive relation has been observed among FN and other parameters of liver function such as serum albumin, cholinesterase activity, fibrinogen and prothrombin time. Plasma FN has a low sensitivity but a high specificity and a good positive predictive value in distinguishing normals and patients with liver disorders different from cirrhosis. This diagnostic value is similar to that of serum albumin.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/0009-8981(86)90196-8</identifier><identifier>PMID: 3539410</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Age Factors ; Aged ; Body Weight ; Cirrhosis ; Diagnosis, Differential ; Female ; Fibronectin ; Fibronectins - blood ; Humans ; Immunologic Techniques ; Liver Cirrhosis - blood ; Liver Cirrhosis - diagnosis ; Liver diagnosis ; Liver Diseases - diagnosis ; Male ; Middle Aged ; Nephelometry and Turbidimetry ; Serologic Tests ; Serum Albumin - analysis</subject><ispartof>Clinica chimica acta, 1986-11, Vol.160 (3), p.289-296</ispartof><rights>1986</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-c1f0dcaff62e0b346e1c22283c9fa31c5b478aa0c23e557f3f528cd94fd1f6b53</citedby><cites>FETCH-LOGICAL-c357t-c1f0dcaff62e0b346e1c22283c9fa31c5b478aa0c23e557f3f528cd94fd1f6b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0009-8981(86)90196-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3539410$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gabrielli, Giovanni B.</creatorcontrib><creatorcontrib>Casaril, Massimo</creatorcontrib><creatorcontrib>Bonazzi, Luisa</creatorcontrib><creatorcontrib>Baracchino, Fiorenza</creatorcontrib><creatorcontrib>Bellisola, Giuseppe</creatorcontrib><creatorcontrib>Corrocher, Roberto</creatorcontrib><title>Plasma fibronectin in liver cirrhosis and its diagnostic value</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>Plasma fibronectin (FN) has been measured by immunonephelometric method in 100 cirrhotic patients and compared with that of 77 normal subjects and with that of 57 patients suffering from liver disorders different from cirrhosis. Both, compensated and decompensated cirrhotics had lower plasma FN than controls (31.14 ± 11.42 and 20.88 ± 10.43 respectively vs 40.13 ± 8.58 mg/dl;
p < 0.02 and
p <0.001). FN in ascitic patients was lower than in non-ascitic (
p < 0.001). These differences were not due to different weight or age of patients. It appears, therefore, that FN parallels in cirrhosis the grade of liver function impairment. No significant difference has been noted between plasma FN of patients with liver diseases different from cirrhosis and control subjects. In cirrhosis, a positive relation has been observed among FN and other parameters of liver function such as serum albumin, cholinesterase activity, fibrinogen and prothrombin time. Plasma FN has a low sensitivity but a high specificity and a good positive predictive value in distinguishing normals and patients with liver disorders different from cirrhosis. This diagnostic value is similar to that of serum albumin.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Body Weight</subject><subject>Cirrhosis</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Fibronectin</subject><subject>Fibronectins - blood</subject><subject>Humans</subject><subject>Immunologic Techniques</subject><subject>Liver Cirrhosis - blood</subject><subject>Liver Cirrhosis - diagnosis</subject><subject>Liver diagnosis</subject><subject>Liver Diseases - diagnosis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nephelometry and Turbidimetry</subject><subject>Serologic Tests</subject><subject>Serum Albumin - analysis</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LxDAQxYMo67r6DRR6Ej1Uk6ZNk8uCLP6DBT3oOaSTiUa67Zq0C357W3fZozAwDPPeG-ZHyDmjN4wycUspValUkl1Jca0oUyKVB2TKZMlTnqvskEz3kmNyEuPXMOZUsAmZ8IKrnNEpmb_WJq5M4nwV2gah800yVO03GBLwIXy20cfENDbxXUysNx9NGzsPycbUPZ6SI2fqiGe7PiPvD_dvi6d0-fL4vLhbpsCLskuBOWrBOCcypBXPBTLIskxyUM5wBkWVl9IYChnHoigdd0UmwarcWeZEVfAZudzmrkP73WPs9MpHwLo2DbZ91GU5vC_4KMy3QghtjAGdXge_MuFHM6pHbHpkokcmWgr9h03LwXaxy--rFdq9acdp2M-3exye3HgMOoLHBtD6MEDTtvX_H_gFhK18cg</recordid><startdate>19861115</startdate><enddate>19861115</enddate><creator>Gabrielli, Giovanni B.</creator><creator>Casaril, Massimo</creator><creator>Bonazzi, Luisa</creator><creator>Baracchino, Fiorenza</creator><creator>Bellisola, Giuseppe</creator><creator>Corrocher, Roberto</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19861115</creationdate><title>Plasma fibronectin in liver cirrhosis and its diagnostic value</title><author>Gabrielli, Giovanni B. ; Casaril, Massimo ; Bonazzi, Luisa ; Baracchino, Fiorenza ; Bellisola, Giuseppe ; Corrocher, Roberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-c1f0dcaff62e0b346e1c22283c9fa31c5b478aa0c23e557f3f528cd94fd1f6b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Body Weight</topic><topic>Cirrhosis</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Fibronectin</topic><topic>Fibronectins - blood</topic><topic>Humans</topic><topic>Immunologic Techniques</topic><topic>Liver Cirrhosis - blood</topic><topic>Liver Cirrhosis - diagnosis</topic><topic>Liver diagnosis</topic><topic>Liver Diseases - diagnosis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nephelometry and Turbidimetry</topic><topic>Serologic Tests</topic><topic>Serum Albumin - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gabrielli, Giovanni B.</creatorcontrib><creatorcontrib>Casaril, Massimo</creatorcontrib><creatorcontrib>Bonazzi, Luisa</creatorcontrib><creatorcontrib>Baracchino, Fiorenza</creatorcontrib><creatorcontrib>Bellisola, Giuseppe</creatorcontrib><creatorcontrib>Corrocher, Roberto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gabrielli, Giovanni B.</au><au>Casaril, Massimo</au><au>Bonazzi, Luisa</au><au>Baracchino, Fiorenza</au><au>Bellisola, Giuseppe</au><au>Corrocher, Roberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma fibronectin in liver cirrhosis and its diagnostic value</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>1986-11-15</date><risdate>1986</risdate><volume>160</volume><issue>3</issue><spage>289</spage><epage>296</epage><pages>289-296</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>Plasma fibronectin (FN) has been measured by immunonephelometric method in 100 cirrhotic patients and compared with that of 77 normal subjects and with that of 57 patients suffering from liver disorders different from cirrhosis. Both, compensated and decompensated cirrhotics had lower plasma FN than controls (31.14 ± 11.42 and 20.88 ± 10.43 respectively vs 40.13 ± 8.58 mg/dl;
p < 0.02 and
p <0.001). FN in ascitic patients was lower than in non-ascitic (
p < 0.001). These differences were not due to different weight or age of patients. It appears, therefore, that FN parallels in cirrhosis the grade of liver function impairment. No significant difference has been noted between plasma FN of patients with liver diseases different from cirrhosis and control subjects. In cirrhosis, a positive relation has been observed among FN and other parameters of liver function such as serum albumin, cholinesterase activity, fibrinogen and prothrombin time. Plasma FN has a low sensitivity but a high specificity and a good positive predictive value in distinguishing normals and patients with liver disorders different from cirrhosis. This diagnostic value is similar to that of serum albumin.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>3539410</pmid><doi>10.1016/0009-8981(86)90196-8</doi><tpages>8</tpages></addata></record> |
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| ispartof | Clinica chimica acta, 1986-11, Vol.160 (3), p.289-296 |
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| subjects | Adult Age Factors Aged Body Weight Cirrhosis Diagnosis, Differential Female Fibronectin Fibronectins - blood Humans Immunologic Techniques Liver Cirrhosis - blood Liver Cirrhosis - diagnosis Liver diagnosis Liver Diseases - diagnosis Male Middle Aged Nephelometry and Turbidimetry Serologic Tests Serum Albumin - analysis |
| title | Plasma fibronectin in liver cirrhosis and its diagnostic value |
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