Gastroprotective effect from Calophyllum brasiliense Camb. bark on experimental gastric lesions in rats and mice
In order to establish the pharmacological basis for the ethnomedicinal use of stem bark extracts of Calophyllum brasiliense Camb. in gastrointestinal affections, this study examined the effects of a dichloromethane fraction (DCMF), obtained from the hexane extract of bark, on ethanol, indomethacin a...
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| Veröffentlicht in: | Journal of ethnopharmacology 1999-11, Vol.67 (2), p.149-156 |
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| container_title | Journal of ethnopharmacology |
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| creator | Sartori, N.T Canepelle, D de Sousa, P.T Martins, D.T.O |
| description | In order to establish the pharmacological basis for the ethnomedicinal use of stem bark extracts of
Calophyllum brasiliense Camb. in gastrointestinal affections, this study examined the effects of a dichloromethane fraction (DCMF), obtained from the hexane extract of bark, on ethanol, indomethacin and hypothermic restraint stress-induced gastric lesions in mice and rats, respectively. Oral administration of DCMF at doses ranging from 12.5–250 mg/kg significantly inhibited the development of gastric lesions in all the three test models. It caused significant decreases of the pyloric-ligation and bethanechol-stimulated gastric secretion, and also the free and total acidities. Besides, DCMF offered protection against ethanol-induced depletion of stomach wall mucus and reduction in nonprotein sulfhydryl concentration. The results indicate that DCMF from
C.
brasiliense possesses antisecretory, antiulcer and cytoprotective properties. |
| doi_str_mv | 10.1016/S0378-8741(98)00244-X |
| format | Article |
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Calophyllum brasiliense Camb. in gastrointestinal affections, this study examined the effects of a dichloromethane fraction (DCMF), obtained from the hexane extract of bark, on ethanol, indomethacin and hypothermic restraint stress-induced gastric lesions in mice and rats, respectively. Oral administration of DCMF at doses ranging from 12.5–250 mg/kg significantly inhibited the development of gastric lesions in all the three test models. It caused significant decreases of the pyloric-ligation and bethanechol-stimulated gastric secretion, and also the free and total acidities. Besides, DCMF offered protection against ethanol-induced depletion of stomach wall mucus and reduction in nonprotein sulfhydryl concentration. The results indicate that DCMF from
C.
brasiliense possesses antisecretory, antiulcer and cytoprotective properties.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/S0378-8741(98)00244-X</identifier><identifier>PMID: 10619378</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject><![CDATA[Administration, Oral ; Animals ; Anti-Ulcer Agents - administration & dosage ; Anti-Ulcer Agents - isolation & purification ; Anti-Ulcer Agents - therapeutic use ; Bark extract ; Biological and medical sciences ; Calophyllum brasiliense ; Digestive system ; Dose-Response Relationship, Drug ; Ethanol - antagonists & inhibitors ; Ethanol - toxicity ; ethnobotany ; Gastric Acid - metabolism ; Gastroprotection ; General pharmacology ; guanandi ; Hypothermia - complications ; Indomethacin - antagonists & inhibitors ; Indomethacin - toxicity ; Male ; Medical sciences ; medicinal plants ; medicinal properties ; Mice ; Peptic Ulcer - etiology ; Peptic Ulcer - prevention & control ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - administration & dosage ; Plant Extracts - therapeutic use ; Rats ; Rats, Wistar ; Restraint, Physical ; stomach ulcers ; Stress, Physiological ; Ulcer inhibition]]></subject><ispartof>Journal of ethnopharmacology, 1999-11, Vol.67 (2), p.149-156</ispartof><rights>1999 Elsevier Science Ireland Ltd</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-c91d55b90677dec3a0eb742c024d9bb70c2f87461b581c51056fafb583d4415c3</citedby><cites>FETCH-LOGICAL-c512t-c91d55b90677dec3a0eb742c024d9bb70c2f87461b581c51056fafb583d4415c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S037887419800244X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1942293$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10619378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sartori, N.T</creatorcontrib><creatorcontrib>Canepelle, D</creatorcontrib><creatorcontrib>de Sousa, P.T</creatorcontrib><creatorcontrib>Martins, D.T.O</creatorcontrib><title>Gastroprotective effect from Calophyllum brasiliense Camb. bark on experimental gastric lesions in rats and mice</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>In order to establish the pharmacological basis for the ethnomedicinal use of stem bark extracts of
Calophyllum brasiliense Camb. in gastrointestinal affections, this study examined the effects of a dichloromethane fraction (DCMF), obtained from the hexane extract of bark, on ethanol, indomethacin and hypothermic restraint stress-induced gastric lesions in mice and rats, respectively. Oral administration of DCMF at doses ranging from 12.5–250 mg/kg significantly inhibited the development of gastric lesions in all the three test models. It caused significant decreases of the pyloric-ligation and bethanechol-stimulated gastric secretion, and also the free and total acidities. Besides, DCMF offered protection against ethanol-induced depletion of stomach wall mucus and reduction in nonprotein sulfhydryl concentration. The results indicate that DCMF from
C.
brasiliense possesses antisecretory, antiulcer and cytoprotective properties.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Anti-Ulcer Agents - administration & dosage</subject><subject>Anti-Ulcer Agents - isolation & purification</subject><subject>Anti-Ulcer Agents - therapeutic use</subject><subject>Bark extract</subject><subject>Biological and medical sciences</subject><subject>Calophyllum brasiliense</subject><subject>Digestive system</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ethanol - antagonists & inhibitors</subject><subject>Ethanol - toxicity</subject><subject>ethnobotany</subject><subject>Gastric Acid - metabolism</subject><subject>Gastroprotection</subject><subject>General pharmacology</subject><subject>guanandi</subject><subject>Hypothermia - complications</subject><subject>Indomethacin - antagonists & inhibitors</subject><subject>Indomethacin - toxicity</subject><subject>Male</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>Mice</subject><subject>Peptic Ulcer - etiology</subject><subject>Peptic Ulcer - prevention & control</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - therapeutic use</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Restraint, Physical</subject><subject>stomach ulcers</subject><subject>Stress, Physiological</subject><subject>Ulcer inhibition</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9vFSEUxYnR2NfqR1BZmFQXU4GBYVgZ86LVpImL2qQ7AsyloswwhXmN_fbyOi_qzhX_fudezrkIvaDkjBLavbskreybXnL6RvVvCWGcN9eP0Ib2kjVSyPYx2vxBjtBxKT8IIZJy8hQdUdJRVR83aD43ZclpzmkBt4Q7wOB93WGf04i3Jqb5-32MuxHbbEqIAaYC9X60Z9ia_BOnCcOvGXIYYVpMxDf7esHhCCWkqeAw4WyWgs004DE4eIaeeBMLPD-sJ-jq08dv28_NxdfzL9sPF40TlC2NU3QQwirSSTmAaw0BKzlz1eegrJXEMV-dddSKnlYJEZ03vh7agXMqXHuCTte61drtDsqix1AcxGgmSLuipaSqE1KoSoqVdDmVksHrubox-V5TovdZ64es9T5IrXr9kLW-rrqXhw47O8Lwj2oNtwKvD4ApzkSfzeRC-cspzphqK_ZqxbxJ2tzkilxdMkJbwhTvlewq8X4loAZ2FyDr4uogHAwh11npIYX__PU3mcSl7A</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>Sartori, N.T</creator><creator>Canepelle, D</creator><creator>de Sousa, P.T</creator><creator>Martins, D.T.O</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19991101</creationdate><title>Gastroprotective effect from Calophyllum brasiliense Camb. bark on experimental gastric lesions in rats and mice</title><author>Sartori, N.T ; Canepelle, D ; de Sousa, P.T ; Martins, D.T.O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-c91d55b90677dec3a0eb742c024d9bb70c2f87461b581c51056fafb583d4415c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Anti-Ulcer Agents - administration & dosage</topic><topic>Anti-Ulcer Agents - isolation & purification</topic><topic>Anti-Ulcer Agents - therapeutic use</topic><topic>Bark extract</topic><topic>Biological and medical sciences</topic><topic>Calophyllum brasiliense</topic><topic>Digestive system</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ethanol - antagonists & inhibitors</topic><topic>Ethanol - toxicity</topic><topic>ethnobotany</topic><topic>Gastric Acid - metabolism</topic><topic>Gastroprotection</topic><topic>General pharmacology</topic><topic>guanandi</topic><topic>Hypothermia - complications</topic><topic>Indomethacin - antagonists & inhibitors</topic><topic>Indomethacin - toxicity</topic><topic>Male</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Mice</topic><topic>Peptic Ulcer - etiology</topic><topic>Peptic Ulcer - prevention & control</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - therapeutic use</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Restraint, Physical</topic><topic>stomach ulcers</topic><topic>Stress, Physiological</topic><topic>Ulcer inhibition</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sartori, N.T</creatorcontrib><creatorcontrib>Canepelle, D</creatorcontrib><creatorcontrib>de Sousa, P.T</creatorcontrib><creatorcontrib>Martins, D.T.O</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sartori, N.T</au><au>Canepelle, D</au><au>de Sousa, P.T</au><au>Martins, D.T.O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastroprotective effect from Calophyllum brasiliense Camb. bark on experimental gastric lesions in rats and mice</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>67</volume><issue>2</issue><spage>149</spage><epage>156</epage><pages>149-156</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>In order to establish the pharmacological basis for the ethnomedicinal use of stem bark extracts of
Calophyllum brasiliense Camb. in gastrointestinal affections, this study examined the effects of a dichloromethane fraction (DCMF), obtained from the hexane extract of bark, on ethanol, indomethacin and hypothermic restraint stress-induced gastric lesions in mice and rats, respectively. Oral administration of DCMF at doses ranging from 12.5–250 mg/kg significantly inhibited the development of gastric lesions in all the three test models. It caused significant decreases of the pyloric-ligation and bethanechol-stimulated gastric secretion, and also the free and total acidities. Besides, DCMF offered protection against ethanol-induced depletion of stomach wall mucus and reduction in nonprotein sulfhydryl concentration. The results indicate that DCMF from
C.
brasiliense possesses antisecretory, antiulcer and cytoprotective properties.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10619378</pmid><doi>10.1016/S0378-8741(98)00244-X</doi><tpages>8</tpages></addata></record> |
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| subjects | Administration, Oral Animals Anti-Ulcer Agents - administration & dosage Anti-Ulcer Agents - isolation & purification Anti-Ulcer Agents - therapeutic use Bark extract Biological and medical sciences Calophyllum brasiliense Digestive system Dose-Response Relationship, Drug Ethanol - antagonists & inhibitors Ethanol - toxicity ethnobotany Gastric Acid - metabolism Gastroprotection General pharmacology guanandi Hypothermia - complications Indomethacin - antagonists & inhibitors Indomethacin - toxicity Male Medical sciences medicinal plants medicinal properties Mice Peptic Ulcer - etiology Peptic Ulcer - prevention & control Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - administration & dosage Plant Extracts - therapeutic use Rats Rats, Wistar Restraint, Physical stomach ulcers Stress, Physiological Ulcer inhibition |
| title | Gastroprotective effect from Calophyllum brasiliense Camb. bark on experimental gastric lesions in rats and mice |
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