Sulfhydryl group(s) in the ligand binding site of the D-1 dopamine receptor: specific protection by agonist and antagonist

An iodinated compound, [125I]-8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin -7-ol, has been recently reported [Sidhu, A., & Kebabian, J.W. (1985) Eur. J. Pharmacol. 113, 437-440] to be a specific ligand for the D-1 dopamine receptor. Due to its high affinity and specific activity,...

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Veröffentlicht in:	Biochemistry (Easton) 1986-10, Vol.25 (21), p.6695-6701
Hauptverfasser:	Sidhu, Anita, Kassis, Shouki, Kebabian, John, Fishman, Peter H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism AMINES ANIMALS AROMATICS AUTONOMIC NERVOUS SYSTEM AGENTS Benzazepines - analogs & derivatives Benzazepines - metabolism BETA DECAY RADIOISOTOPES BODY BRAIN CARDIOTONICS CARDIOVASCULAR AGENTS caudate nucleus Caudate Nucleus - metabolism Cell Fusion Cell Membrane - metabolism CENTRAL NERVOUS SYSTEM Corpus Striatum - metabolism CYCLASES DAYS LIVING RADIOISOTOPES DOPAMINE dopamine D1 DRUGS ELECTRON CAPTURE RADIOISOTOPES ENZYMES HELA CELLS HeLa Cells - metabolism Humans HYDROXY COMPOUNDS INTERMEDIATE MASS NUCLEI IODINE 125 IODINE ISOTOPES ISOTOPE APPLICATIONS ISOTOPES Kinetics LABELLED COMPOUNDS LIGANDS LYASES Male MAMMALS MEMBRANE PROTEINS MOLECULAR STRUCTURE N-ethylmaleimide neostriatum NERVOUS SYSTEM NEUROREGULATORS NUCLEI ODD-EVEN NUCLEI ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS ORGANIC IODINE COMPOUNDS ORGANS PHENOLS POLYPHENOLS PROTEINS RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE RADIORECEPTOR ASSAY RATS Rats, Inbred Strains RECEPTORS Receptors, Dopamine - drug effects Receptors, Dopamine - metabolism RODENTS SCH 23390 Sulfhydryl Compounds SYMPATHOMIMETICS TRACER TECHNIQUES VERTEBRATES 550601 > Medicine-- Unsealed Radionuclides in Diagnostics
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