Solubilization of dopamine D2 receptors with a zwitterionic detergent DCHAPS

Dopamine D2 receptors were solubilized from synaptosomal membranes of the bovine caudate nucleus using a novel zwitterionic detergent 3-[(3-deoxycholamidopropyl)-dimethylammonio]-1-propane sulfonate (DCHAPS) supplemented with 1,2-propylene glycol. Optimal conditions for solubilization were: 0.12% DC...

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Veröffentlicht in:	Biochemical pharmacology 1986-12, Vol.35 (23), p.4229-4236
Hauptverfasser:	SOSKIC, V, PETROVIC, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Applied sciences Biological and medical sciences Catecholaminergic system Cattle Cholic Acids - pharmacology Chromatography, Gel Chromatography, Ion Exchange Detergents - pharmacology Exact sciences and technology In Vitro Techniques Kinetics Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Other techniques and industries Pharmacology. Drug treatments Receptors, Dopamine - isolation & purification Receptors, Dopamine - metabolism Receptors, Dopamine D2 Sodium Chloride - pharmacology Solubility Spiperone - metabolism Stereoisomerism Surface-Active Agents - pharmacology
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