Tumor Necrosis Factor Reduces c-myc Expression and Cooperates with Interferon-γ in HeLa Cells

The suppression of the c-myc nuclear oncogene is associated with growth arrest and may therefore be directly controlled by naturally occurring growth inhibitors. The effect of tumor necrosis factor (TNF) and of interferon-γ (IFN-γ) on c-myc expression was investigated in HeLa cells, which respond to...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1986-12, Vol.234 (4782), p.1419-1421
Hauptverfasser:	Yarden, Anat, Kimchi, Adi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell cycle Cell growth Cell physiology Cell Survival Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Complementary DNA Cycloheximide - pharmacology Cytokines Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Glycoproteins - pharmacology HeLa cells HeLa Cells - metabolism HLA antigens HLA B antigens Humans Interferon Interferon-gamma - pharmacology Messenger RNA Molecular and cellular biology Oncogenes RNA RNA, Messenger - metabolism Transcription, Genetic Tumor necrosis factor Tumor Necrosis Factor-alpha Tumor necrosis factors
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