Prothrombin clamart : prothrombin variant with defective arg 320-IIe cleavage by factor xa

An abnormal prothrombin has been detected in a 23 yr-old healthy female and her mother. Both patients appeared to be heterozygous for the abnormality, plasma prothrombin being 50 % of normal using the usual one stage assay, but normal when measured either by using Echis carinatus venom or by immunoa...

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