A Hydroxyquinone with Amine Oxidase Activity: Preparation and Properties
The preparation and some properties of a hydroxyquinone showing an amine oxidase-like activity are described. The compound, 2-hydroxy-5-methyl-1,4-benzoquinone, oxidizes a wide range of primary amines, both benzylic and non-benzylic, at the expenses of molecular oxygen in the presence of Cu2+ ions,...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1995-03, Vol.208 (2), p.825-834 |
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| container_end_page | 834 |
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| container_title | Biochemical and biophysical research communications |
| container_volume | 208 |
| creator | Sanjust, E. Rinaldi, A.C. Rescigno, A. Porcu, M.C. Alberti, G. Rinaldi, A. Finazziagro, A. |
| description | The preparation and some properties of a hydroxyquinone showing an amine oxidase-like activity are described. The compound, 2-hydroxy-5-methyl-1,4-benzoquinone, oxidizes a wide range of primary amines, both benzylic and non-benzylic, at the expenses of molecular oxygen in the presence of Cu2+ ions, and reacts with hydrazine derivatives leading to stable, inactive adducts. This behaviour is similar to that of 2,4,5-trihydroxyphenylalanine quinone-containing amine oxidases and therefore the present compound could be a useful model to understand the reaction mechanism of those enzymes. |
| doi_str_mv | 10.1006/bbrc.1995.1411 |
| format | Article |
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The compound, 2-hydroxy-5-methyl-1,4-benzoquinone, oxidizes a wide range of primary amines, both benzylic and non-benzylic, at the expenses of molecular oxygen in the presence of Cu2+ ions, and reacts with hydrazine derivatives leading to stable, inactive adducts. 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| ispartof | Biochemical and biophysical research communications, 1995-03, Vol.208 (2), p.825-834 |
| issn | 0006-291X 1090-2104 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77190510 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Amine Oxidase (Copper-Containing) Amines - chemistry Benzoquinones - chemistry Gas Chromatography-Mass Spectrometry Oxidation-Reduction Oxidoreductases Acting on CH-NH Group Donors - chemistry Quinones - chemistry Spectrum Analysis Structure-Activity Relationship |
| title | A Hydroxyquinone with Amine Oxidase Activity: Preparation and Properties |
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