Laminar distribution and somatotopic organization of primary afferent fibers from hindlimb nerves in the dorsal horn. A study by transganglionic transport of horseradish peroxidase in the rat
Primary afferent nerve fibers to the spinal cord in the adult rat were labeled by applying horseradish peroxidase to the cut end of one of the following hindlimb nerves; the tibial, medial plantar, lateral plantar, common peroneal, saphenous, sural, lateral femoral cutaneous or obturator nerve. Maxi...
Gespeichert in:
| Veröffentlicht in: | Neuroscience 1986-09, Vol.19 (1), p.297-312 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 312 |
|---|---|
| container_issue | 1 |
| container_start_page | 297 |
| container_title | Neuroscience |
| container_volume | 19 |
| creator | Molander, C. Grant, G. |
| description | Primary afferent nerve fibers to the spinal cord in the adult rat were labeled by applying horseradish peroxidase to the cut end of one of the following hindlimb nerves; the tibial, medial plantar, lateral plantar, common peroneal, saphenous, sural, lateral femoral cutaneous or obturator nerve. Maximal labeling intensity was found in the dorsal horn after 36–72 h survival. Labeling was observed in different dorsal horn laminae at different levels within the L1-S1 spinal cord segments, depending on which nerve horseradish peroxidase had been exposed to, probably reflecting the individual composition of afferent fiber types.
Although a certain overlap was found, the central projections of the eight different nerves investigated formed well delineated three dimensional compartments within the medial 2/3 to 3/4 of the dorsal horn. This was most clearly discernible in lamina II. Although interindividual differences were present, bilaterally identical operations gave symmetrical projection patterns in the dorsal horn. The results indicate that dorsal horn projections of hindlimb nerves are organized in a highly ordered somatotopic fashion. |
| doi_str_mv | 10.1016/0306-4522(86)90023-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77189222</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0306452286900230</els_id><sourcerecordid>14643726</sourcerecordid><originalsourceid>FETCH-LOGICAL-c483t-30d07f38adf9780c727da4da59e48a2f7370dc6cec8c828cbe6f74f30faf185e3</originalsourceid><addsrcrecordid>eNqFks2OFCEUhYnRjG3rG2jCwhhd1EgVVEFvTCYT_5JO3Oia3ILLNKYKWqAnti_nq0n_2EtlQ-B8nHtzD4Q8b9l1y9rhLeNsaETfda_V8GbFWMcb9oAsWiV5I3shHpLFBXlMnuT8ndXVC35FrrhU_TCoBfm9htkHSNT6XJIfd8XHQCFYmuMMJZa49YbGdAfB_4KjGB3dJj9D2lNwDhOGQp0fMWXqUpzpxgc7-XmkAdM9ZuoDLRukNqYME93EFK7pDc1lZ_d03NOSIORqfzdV81rreN7GVA6FKp0xQW1uQ7eY4k9vIeNfywTlKXnkYMr47LwvybcP77_efmrWXz5-vr1ZN0YoXhrOLJOOK7BuJRUzspMWhIV-hUJB5ySXzJrBoFFGdcqMODgpHGcOXKt65Evy6uS7TfHHDnPRs88GpwkCxl3WUrZq1XXdf8FWDILLbqigOIEmxZwTOn2eqm6ZPgSsD-npQ3paDfoYcL1akhdn_904o708Oida9ZdnHbKBydVpGp8vmFwd_oes2LsThnVo9x6TzsZjMGh9QlO0jf7fffwBf4_Hew</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14643726</pqid></control><display><type>article</type><title>Laminar distribution and somatotopic organization of primary afferent fibers from hindlimb nerves in the dorsal horn. A study by transganglionic transport of horseradish peroxidase in the rat</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Molander, C. ; Grant, G.</creator><creatorcontrib>Molander, C. ; Grant, G.</creatorcontrib><description>Primary afferent nerve fibers to the spinal cord in the adult rat were labeled by applying horseradish peroxidase to the cut end of one of the following hindlimb nerves; the tibial, medial plantar, lateral plantar, common peroneal, saphenous, sural, lateral femoral cutaneous or obturator nerve. Maximal labeling intensity was found in the dorsal horn after 36–72 h survival. Labeling was observed in different dorsal horn laminae at different levels within the L1-S1 spinal cord segments, depending on which nerve horseradish peroxidase had been exposed to, probably reflecting the individual composition of afferent fiber types.
Although a certain overlap was found, the central projections of the eight different nerves investigated formed well delineated three dimensional compartments within the medial 2/3 to 3/4 of the dorsal horn. This was most clearly discernible in lamina II. Although interindividual differences were present, bilaterally identical operations gave symmetrical projection patterns in the dorsal horn. The results indicate that dorsal horn projections of hindlimb nerves are organized in a highly ordered somatotopic fashion.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/0306-4522(86)90023-0</identifier><identifier>PMID: 3785668</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Afferent Pathways - physiology ; Animals ; Biological and medical sciences ; Cell Count ; Female ; Fundamental and applied biological sciences. Psychology ; Ganglia, Spinal - cytology ; Ganglia, Spinal - metabolism ; Ganglia, Spinal - physiology ; Hindlimb - innervation ; Horseradish Peroxidase ; HRP ; I,II ...IX ; IIi ; IIo ; inner part of lamina II ; outer part of lamina II ; Rats ; Rats, Inbred Strains ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Spinal Cord - cytology ; Spinal Cord - metabolism ; Spinal Cord - physiology ; spinal cord laminae ; Spinal Nerves - metabolism ; Spinal Nerves - physiology ; tetramethylbenzidine ; Time Factors ; TMB ; Vertebrates: nervous system and sense organs ; WGA-HRP wheat germ agglutinin-horseradish peroxidase conjugate</subject><ispartof>Neuroscience, 1986-09, Vol.19 (1), p.297-312</ispartof><rights>1986 IBRO</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-30d07f38adf9780c727da4da59e48a2f7370dc6cec8c828cbe6f74f30faf185e3</citedby><cites>FETCH-LOGICAL-c483t-30d07f38adf9780c727da4da59e48a2f7370dc6cec8c828cbe6f74f30faf185e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0306-4522(86)90023-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7918737$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3785668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Molander, C.</creatorcontrib><creatorcontrib>Grant, G.</creatorcontrib><title>Laminar distribution and somatotopic organization of primary afferent fibers from hindlimb nerves in the dorsal horn. A study by transganglionic transport of horseradish peroxidase in the rat</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Primary afferent nerve fibers to the spinal cord in the adult rat were labeled by applying horseradish peroxidase to the cut end of one of the following hindlimb nerves; the tibial, medial plantar, lateral plantar, common peroneal, saphenous, sural, lateral femoral cutaneous or obturator nerve. Maximal labeling intensity was found in the dorsal horn after 36–72 h survival. Labeling was observed in different dorsal horn laminae at different levels within the L1-S1 spinal cord segments, depending on which nerve horseradish peroxidase had been exposed to, probably reflecting the individual composition of afferent fiber types.
Although a certain overlap was found, the central projections of the eight different nerves investigated formed well delineated three dimensional compartments within the medial 2/3 to 3/4 of the dorsal horn. This was most clearly discernible in lamina II. Although interindividual differences were present, bilaterally identical operations gave symmetrical projection patterns in the dorsal horn. The results indicate that dorsal horn projections of hindlimb nerves are organized in a highly ordered somatotopic fashion.</description><subject>Afferent Pathways - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Count</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglia, Spinal - cytology</subject><subject>Ganglia, Spinal - metabolism</subject><subject>Ganglia, Spinal - physiology</subject><subject>Hindlimb - innervation</subject><subject>Horseradish Peroxidase</subject><subject>HRP</subject><subject>I,II ...IX</subject><subject>IIi</subject><subject>IIo</subject><subject>inner part of lamina II</subject><subject>outer part of lamina II</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Spinal Cord - cytology</subject><subject>Spinal Cord - metabolism</subject><subject>Spinal Cord - physiology</subject><subject>spinal cord laminae</subject><subject>Spinal Nerves - metabolism</subject><subject>Spinal Nerves - physiology</subject><subject>tetramethylbenzidine</subject><subject>Time Factors</subject><subject>TMB</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>WGA-HRP wheat germ agglutinin-horseradish peroxidase conjugate</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks2OFCEUhYnRjG3rG2jCwhhd1EgVVEFvTCYT_5JO3Oia3ILLNKYKWqAnti_nq0n_2EtlQ-B8nHtzD4Q8b9l1y9rhLeNsaETfda_V8GbFWMcb9oAsWiV5I3shHpLFBXlMnuT8ndXVC35FrrhU_TCoBfm9htkHSNT6XJIfd8XHQCFYmuMMJZa49YbGdAfB_4KjGB3dJj9D2lNwDhOGQp0fMWXqUpzpxgc7-XmkAdM9ZuoDLRukNqYME93EFK7pDc1lZ_d03NOSIORqfzdV81rreN7GVA6FKp0xQW1uQ7eY4k9vIeNfywTlKXnkYMr47LwvybcP77_efmrWXz5-vr1ZN0YoXhrOLJOOK7BuJRUzspMWhIV-hUJB5ySXzJrBoFFGdcqMODgpHGcOXKt65Evy6uS7TfHHDnPRs88GpwkCxl3WUrZq1XXdf8FWDILLbqigOIEmxZwTOn2eqm6ZPgSsD-npQ3paDfoYcL1akhdn_904o708Oida9ZdnHbKBydVpGp8vmFwd_oes2LsThnVo9x6TzsZjMGh9QlO0jf7fffwBf4_Hew</recordid><startdate>19860901</startdate><enddate>19860901</enddate><creator>Molander, C.</creator><creator>Grant, G.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19860901</creationdate><title>Laminar distribution and somatotopic organization of primary afferent fibers from hindlimb nerves in the dorsal horn. A study by transganglionic transport of horseradish peroxidase in the rat</title><author>Molander, C. ; Grant, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-30d07f38adf9780c727da4da59e48a2f7370dc6cec8c828cbe6f74f30faf185e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Afferent Pathways - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Count</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglia, Spinal - cytology</topic><topic>Ganglia, Spinal - metabolism</topic><topic>Ganglia, Spinal - physiology</topic><topic>Hindlimb - innervation</topic><topic>Horseradish Peroxidase</topic><topic>HRP</topic><topic>I,II ...IX</topic><topic>IIi</topic><topic>IIo</topic><topic>inner part of lamina II</topic><topic>outer part of lamina II</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Spinal Cord - cytology</topic><topic>Spinal Cord - metabolism</topic><topic>Spinal Cord - physiology</topic><topic>spinal cord laminae</topic><topic>Spinal Nerves - metabolism</topic><topic>Spinal Nerves - physiology</topic><topic>tetramethylbenzidine</topic><topic>Time Factors</topic><topic>TMB</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>WGA-HRP wheat germ agglutinin-horseradish peroxidase conjugate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Molander, C.</creatorcontrib><creatorcontrib>Grant, G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Molander, C.</au><au>Grant, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Laminar distribution and somatotopic organization of primary afferent fibers from hindlimb nerves in the dorsal horn. A study by transganglionic transport of horseradish peroxidase in the rat</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>1986-09-01</date><risdate>1986</risdate><volume>19</volume><issue>1</issue><spage>297</spage><epage>312</epage><pages>297-312</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Primary afferent nerve fibers to the spinal cord in the adult rat were labeled by applying horseradish peroxidase to the cut end of one of the following hindlimb nerves; the tibial, medial plantar, lateral plantar, common peroneal, saphenous, sural, lateral femoral cutaneous or obturator nerve. Maximal labeling intensity was found in the dorsal horn after 36–72 h survival. Labeling was observed in different dorsal horn laminae at different levels within the L1-S1 spinal cord segments, depending on which nerve horseradish peroxidase had been exposed to, probably reflecting the individual composition of afferent fiber types.
Although a certain overlap was found, the central projections of the eight different nerves investigated formed well delineated three dimensional compartments within the medial 2/3 to 3/4 of the dorsal horn. This was most clearly discernible in lamina II. Although interindividual differences were present, bilaterally identical operations gave symmetrical projection patterns in the dorsal horn. The results indicate that dorsal horn projections of hindlimb nerves are organized in a highly ordered somatotopic fashion.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>3785668</pmid><doi>10.1016/0306-4522(86)90023-0</doi><tpages>16</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-4522 |
| ispartof | Neuroscience, 1986-09, Vol.19 (1), p.297-312 |
| issn | 0306-4522 1873-7544 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77189222 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Afferent Pathways - physiology Animals Biological and medical sciences Cell Count Female Fundamental and applied biological sciences. Psychology Ganglia, Spinal - cytology Ganglia, Spinal - metabolism Ganglia, Spinal - physiology Hindlimb - innervation Horseradish Peroxidase HRP I,II ...IX IIi IIo inner part of lamina II outer part of lamina II Rats Rats, Inbred Strains Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal Cord - cytology Spinal Cord - metabolism Spinal Cord - physiology spinal cord laminae Spinal Nerves - metabolism Spinal Nerves - physiology tetramethylbenzidine Time Factors TMB Vertebrates: nervous system and sense organs WGA-HRP wheat germ agglutinin-horseradish peroxidase conjugate |
| title | Laminar distribution and somatotopic organization of primary afferent fibers from hindlimb nerves in the dorsal horn. A study by transganglionic transport of horseradish peroxidase in the rat |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T06%3A55%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Laminar%20distribution%20and%20somatotopic%20organization%20of%20primary%20afferent%20fibers%20from%20hindlimb%20nerves%20in%20the%20dorsal%20horn.%20A%20study%20by%20transganglionic%20transport%20of%20horseradish%20peroxidase%20in%20the%20rat&rft.jtitle=Neuroscience&rft.au=Molander,%20C.&rft.date=1986-09-01&rft.volume=19&rft.issue=1&rft.spage=297&rft.epage=312&rft.pages=297-312&rft.issn=0306-4522&rft.eissn=1873-7544&rft.coden=NRSCDN&rft_id=info:doi/10.1016/0306-4522(86)90023-0&rft_dat=%3Cproquest_cross%3E14643726%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14643726&rft_id=info:pmid/3785668&rft_els_id=0306452286900230&rfr_iscdi=true |