The alpha-Ca2+/calmodulin kinase II: a bidirectional modulator of presynaptic plasticity

The alpha-Ca2+/calmodulin kinase II (alpha CaMKII) is required for long-term potentiation in the CA1 region of the hippocampus. Here, we report that this kinase also has a crucial role in presynaptic plasticity. Paired-pulse facilitation is blunted in the CA1 region of mice heterozygous for a target...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 1995-03, Vol.14 (3), p.591-597
Hauptverfasser:	Chapman, P F, Frenguelli, B G, Smith, A, Chen, C M, Silva, A J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases - genetics Calcium-Calmodulin-Dependent Protein Kinases - metabolism Crosses, Genetic Electric Stimulation Evoked Potentials Heterozygote Hippocampus - physiology In Vitro Techniques Long-Term Potentiation Mice Mice, Inbred C57BL Mice, Neurologic Mutants Mutation Neuronal Plasticity Patch-Clamp Techniques Pyramidal Cells - physiology Synapses - physiology Time Factors
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