Small intestinal transplantation using cyclosporine: report of a case
A case of small intestinal allotransplantation is described. Cyclosporine and Solumedrol were used for immunosuppression. A hemolytic episode occurred, caused by anti-A antibodies derived from graft lymphocytes. Sudden severe encephalopathy developed on the ninth postoperative day, followed by intra...
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| Veröffentlicht in: | Transplantation 1986-12, Vol.42 (6), p.613-621 |
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| container_issue | 6 |
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| container_title | Transplantation |
| container_volume | 42 |
| creator | COHEN, Z SILVERMAN, R. E WASSEF, R LEVY, G. A BURNSTEIN, M CULLEN, J MAKOWKA, L LANGER, B GREENBERG, G. R |
| description | A case of small intestinal allotransplantation is described. Cyclosporine and Solumedrol were used for immunosuppression. A hemolytic episode occurred, caused by anti-A antibodies derived from graft lymphocytes. Sudden severe encephalopathy developed on the ninth postoperative day, followed by intractable hypotension and death. Hepatic and splenic microinfarcts were identified on postmortem examination. Allograft rejection was identified by serial stomal biopsies and correlated with a rise in monocyte procoagulant activity, a potentially useful serologic marker of rejection. The absence of an anatomic circuit for recycling of cyclosporine did not alter serum radioimmunoassay/high-performance liquid chromatography ratios. |
| doi_str_mv | 10.1097/00007890-198612000-00008 |
| format | Article |
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The absence of an anatomic circuit for recycling of cyclosporine did not alter serum radioimmunoassay/high-performance liquid chromatography ratios.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/00007890-198612000-00008</identifier><identifier>PMID: 3787703</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adult ; Biological and medical sciences ; Cyclosporins - therapeutic use ; Female ; Gardner Syndrome - therapy ; Graft Rejection ; Humans ; Immunomodulators ; Immunosuppression ; Infarction ; Intestine, Small - transplantation ; Liver - blood supply ; Medical sciences ; Pharmacology. 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The absence of an anatomic circuit for recycling of cyclosporine did not alter serum radioimmunoassay/high-performance liquid chromatography ratios.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cyclosporins - therapeutic use</subject><subject>Female</subject><subject>Gardner Syndrome - therapy</subject><subject>Graft Rejection</subject><subject>Humans</subject><subject>Immunomodulators</subject><subject>Immunosuppression</subject><subject>Infarction</subject><subject>Intestine, Small - transplantation</subject><subject>Liver - blood supply</subject><subject>Medical sciences</subject><subject>Pharmacology. 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| fulltext | fulltext |
| identifier | ISSN: 0041-1337 |
| ispartof | Transplantation, 1986-12, Vol.42 (6), p.613-621 |
| issn | 0041-1337 1534-6080 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77188084 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Biological and medical sciences Cyclosporins - therapeutic use Female Gardner Syndrome - therapy Graft Rejection Humans Immunomodulators Immunosuppression Infarction Intestine, Small - transplantation Liver - blood supply Medical sciences Pharmacology. Drug treatments Prednisone - pharmacology Splenic Infarction Time Factors |
| title | Small intestinal transplantation using cyclosporine: report of a case |
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