Human Neutrophils Store Type II 14-kDa Phospholipase A2 in Granules and Secrete Active Enzyme in Response to Soluble Stimuli

Although "secretory" type II 14-kDa phospholipase A2 (sPLA2) activity has been described in neutrophils, direct evidence of enzyme secretion has been elusive. We have used immunogold electron microscopy with polyclonal and monoclonal antibodies to sPLA2 to demonstrate localization of the e...

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Veröffentlicht in:	Biochemical and biophysical research communications 1995-03, Vol.208 (2), p.650-656
Hauptverfasser:	Rosenthal, M.D., Gordon, M.N., Buescher, E.S., Slusser, J.H., Harris, L.K., Franson, R.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcimycin - pharmacology Cell Compartmentation Cell Degranulation Cytoplasmic Granules - enzymology Humans Immunohistochemistry In Vitro Techniques Molecular Weight Neutrophil Activation Neutrophils - enzymology Phagosomes - enzymology Phospholipases A - chemistry Phospholipases A - secretion Phospholipases A2
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