3-Methoxytyramine accumulation: effects of typical neuroleptics and various atypical compounds

The accumulation of 3-methoxytyramine (3-MT), the O-methylated metabolite of dopamine (DA), in rat striatum was used to assess the effects of drugs on dopaminergic activity. This was accomplished by pretreating rats with pargyline to completely inhibit 3-MT catabolism. Under the conditions used, 3-M...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 1986-10, Vol.334 (2), p.125-132
Hauptverfasser:	SALLER, C. F, SALAMA, A. I
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - pharmacology Animals Antipsychotic Agents - pharmacology Apomorphine - pharmacology Applied sciences Benzazepines - pharmacology Biological and medical sciences Buspirone Carbazoles - pharmacology Chlorpromazine - pharmacology Clozapine - pharmacology Corpus Striatum - drug effects Corpus Striatum - metabolism Dopamine - analogs & derivatives Dopamine - metabolism Dopamine Antagonists Exact sciences and technology Fluphenazine - pharmacology Haloperidol - pharmacology Male Medical sciences Molindone - pharmacology Neuropharmacology Other techniques and industries Pargyline - pharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Pyrimidines - pharmacology Rats Rats, Inbred Strains Receptors, Dopamine - metabolism Regression Analysis
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