Desipramine enhances opiate postoperative analgesia
In a double-blind, placebo-controlled study the analgesic efficacy of the combination of a tricyclic antidepressant and morphine was investigated. One of two tricyclic antidepressants (either amitriptyline, a relatively selective serotonin uptake inhibitor or desipramine, a relatively selective nora...
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| Veröffentlicht in: | Pain (Amsterdam) 1986-10, Vol.27 (1), p.45-49 |
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| container_end_page | 49 |
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| container_issue | 1 |
| container_start_page | 45 |
| container_title | Pain (Amsterdam) |
| container_volume | 27 |
| creator | Levine, Jon D. Gordon, Newton C. Smith, Richard McBryde, Richard |
| description | In a double-blind, placebo-controlled study the analgesic efficacy of the combination of a tricyclic antidepressant and morphine was investigated. One of two tricyclic antidepressants (either amitriptyline, a relatively selective serotonin uptake inhibitor or desipramine, a relatively selective noradrenaline uptake inhibitor) or a placebo, was given for 1 week prior to surgery, followed by a single postoperative dose of morphine. Desipramine, but not amitriptyline, both increased and prolonged morphine analgesia. Neither tricyclic antidepressant reduced dental postoperative pain in the absence of morphine. We propose that desipramine enhances opiate analgesia by enhancing a noradrenergic component that contributes to endogenous opioid-mediated analgesia systems. |
| doi_str_mv | 10.1016/0304-3959(86)90220-4 |
| format | Article |
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One of two tricyclic antidepressants (either amitriptyline, a relatively selective serotonin uptake inhibitor or desipramine, a relatively selective noradrenaline uptake inhibitor) or a placebo, was given for 1 week prior to surgery, followed by a single postoperative dose of morphine. Desipramine, but not amitriptyline, both increased and prolonged morphine analgesia. Neither tricyclic antidepressant reduced dental postoperative pain in the absence of morphine. We propose that desipramine enhances opiate analgesia by enhancing a noradrenergic component that contributes to endogenous opioid-mediated analgesia systems.</description><identifier>ISSN: 0304-3959</identifier><identifier>EISSN: 1872-6623</identifier><identifier>DOI: 10.1016/0304-3959(86)90220-4</identifier><identifier>PMID: 3785963</identifier><identifier>CODEN: PAINDB</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Amitriptyline - pharmacology ; Analgesia ; Analgesics ; Biological and medical sciences ; Desipramine - pharmacology ; Double-Blind Method ; Drug Combinations ; Drug Therapy, Combination ; Humans ; Medical sciences ; Morphine - pharmacology ; Neuropharmacology ; Pain Measurement ; Pain, Postoperative - drug therapy ; Pain, Postoperative - psychology ; Pharmacology. 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One of two tricyclic antidepressants (either amitriptyline, a relatively selective serotonin uptake inhibitor or desipramine, a relatively selective noradrenaline uptake inhibitor) or a placebo, was given for 1 week prior to surgery, followed by a single postoperative dose of morphine. Desipramine, but not amitriptyline, both increased and prolonged morphine analgesia. Neither tricyclic antidepressant reduced dental postoperative pain in the absence of morphine. We propose that desipramine enhances opiate analgesia by enhancing a noradrenergic component that contributes to endogenous opioid-mediated analgesia systems.</description><subject>Amitriptyline - pharmacology</subject><subject>Analgesia</subject><subject>Analgesics</subject><subject>Biological and medical sciences</subject><subject>Desipramine - pharmacology</subject><subject>Double-Blind Method</subject><subject>Drug Combinations</subject><subject>Drug Therapy, Combination</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Morphine - pharmacology</subject><subject>Neuropharmacology</subject><subject>Pain Measurement</subject><subject>Pain, Postoperative - drug therapy</subject><subject>Pain, Postoperative - psychology</subject><subject>Pharmacology. Drug treatments</subject><subject>Postoperative Period</subject><subject>Preanesthetic Medication</subject><subject>Time Factors</subject><issn>0304-3959</issn><issn>1872-6623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEuP0zAUhS0E6pTCP2CkLBCCRcCvOPZmJDQ8pUpsYG3dODfUM2kc7GQq_j0OjcqOjS37nnPu0UfIC0bfMsrUOyqoLIWpzGut3hjKOS3lI7JluualUlw8JtuL5Io8TemO0qziZkM2otaVUWJLxAdMfoxw9AMWOBxgcJiKMHqYsBhDmsKIESb_gAUM0P_ManhGnnTQJ3y-3jvy49PH77dfyv23z19v3-9LJyvJyy5vR1MxDlVXG4UtVZXjSkJXQV2zVjnXNMY41FrU4BpOoW44VpC_qMrtduTVOXeM4deMabJHnxz2PQwY5mRziBaM8SyUZ6GLIaWInR2jP0L8bRm1Cyu7gLALCKuV_cvKymy7XvPn5ojtxbTCyfOX6xySg76LGY5PF5lmkhop_20_hX7CmO77-YTRHhD66WAzc6qEUSUzWrHlVS7HUvrmbMOM8MFnR3IeM_7WR3STbYP_f_0_sKqUOA</recordid><startdate>19861001</startdate><enddate>19861001</enddate><creator>Levine, Jon D.</creator><creator>Gordon, Newton C.</creator><creator>Smith, Richard</creator><creator>McBryde, Richard</creator><general>Elsevier B.V</general><general>Lippincott-Raven Publishers.Copyright Lippincott-Raven Publishers</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19861001</creationdate><title>Desipramine enhances opiate postoperative analgesia</title><author>Levine, Jon D. ; Gordon, Newton C. ; Smith, Richard ; McBryde, Richard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4542-f030e9512a5f796ed065c264af5a771d6ccbb99ce8837acb20a7b2e5a9ce06963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Amitriptyline - pharmacology</topic><topic>Analgesia</topic><topic>Analgesics</topic><topic>Biological and medical sciences</topic><topic>Desipramine - pharmacology</topic><topic>Double-Blind Method</topic><topic>Drug Combinations</topic><topic>Drug Therapy, Combination</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Morphine - pharmacology</topic><topic>Neuropharmacology</topic><topic>Pain Measurement</topic><topic>Pain, Postoperative - drug therapy</topic><topic>Pain, Postoperative - psychology</topic><topic>Pharmacology. Drug treatments</topic><topic>Postoperative Period</topic><topic>Preanesthetic Medication</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levine, Jon D.</creatorcontrib><creatorcontrib>Gordon, Newton C.</creatorcontrib><creatorcontrib>Smith, Richard</creatorcontrib><creatorcontrib>McBryde, Richard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pain (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levine, Jon D.</au><au>Gordon, Newton C.</au><au>Smith, Richard</au><au>McBryde, Richard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Desipramine enhances opiate postoperative analgesia</atitle><jtitle>Pain (Amsterdam)</jtitle><addtitle>Pain</addtitle><date>1986-10-01</date><risdate>1986</risdate><volume>27</volume><issue>1</issue><spage>45</spage><epage>49</epage><pages>45-49</pages><issn>0304-3959</issn><eissn>1872-6623</eissn><coden>PAINDB</coden><abstract>In a double-blind, placebo-controlled study the analgesic efficacy of the combination of a tricyclic antidepressant and morphine was investigated. One of two tricyclic antidepressants (either amitriptyline, a relatively selective serotonin uptake inhibitor or desipramine, a relatively selective noradrenaline uptake inhibitor) or a placebo, was given for 1 week prior to surgery, followed by a single postoperative dose of morphine. Desipramine, but not amitriptyline, both increased and prolonged morphine analgesia. Neither tricyclic antidepressant reduced dental postoperative pain in the absence of morphine. We propose that desipramine enhances opiate analgesia by enhancing a noradrenergic component that contributes to endogenous opioid-mediated analgesia systems.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>3785963</pmid><doi>10.1016/0304-3959(86)90220-4</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0304-3959 |
| ispartof | Pain (Amsterdam), 1986-10, Vol.27 (1), p.45-49 |
| issn | 0304-3959 1872-6623 |
| language | eng |
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| source | MEDLINE; ScienceDirect Freedom Collection (Elsevier) |
| subjects | Amitriptyline - pharmacology Analgesia Analgesics Biological and medical sciences Desipramine - pharmacology Double-Blind Method Drug Combinations Drug Therapy, Combination Humans Medical sciences Morphine - pharmacology Neuropharmacology Pain Measurement Pain, Postoperative - drug therapy Pain, Postoperative - psychology Pharmacology. Drug treatments Postoperative Period Preanesthetic Medication Time Factors |
| title | Desipramine enhances opiate postoperative analgesia |
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