Antipyretic, analgesic, and anti-inflammatory activities of the seaweed Sargassum fulvellum and Sargassum thunbergii in mice

Dichloromethane, ethanol, and boiling water extracts of the brown seaweeds Sargassum fulvellum and Sargassum thunbergii were examined for antipyretic, analgesic, and anti-inflammatory activities in mice. The activities were evaluated against yeast-induced pyrexia, tail-flick test, and phorbol myrist...

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Veröffentlicht in:Journal of ethnopharmacology 2008-02, Vol.116 (1), p.187-190
Hauptverfasser: Kang, J.Y., Khan, M.N.A., Park, N.H., Cho, J.Y., Lee, M.C., Fujii, H., Hong, Y.K.
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container_end_page 190
container_issue 1
container_start_page 187
container_title Journal of ethnopharmacology
container_volume 116
creator Kang, J.Y.
Khan, M.N.A.
Park, N.H.
Cho, J.Y.
Lee, M.C.
Fujii, H.
Hong, Y.K.
description Dichloromethane, ethanol, and boiling water extracts of the brown seaweeds Sargassum fulvellum and Sargassum thunbergii were examined for antipyretic, analgesic, and anti-inflammatory activities in mice. The activities were evaluated against yeast-induced pyrexia, tail-flick test, and phorbol myristate acetate-induced inflammation (edema, erythema, and blood flow). The dichloromethane extract (0.4 mg/ear) of Sargassum fulvellum inhibited an inflammatory symptom of mouse ear edema by 79.1%. The ethanol extract (0.4 mg/ear) of Sargassum thunbergii also inhibited edema by 72.1%. No acute toxicity was observed after p.o. administration of each extract (5 g/kg bw). These findings are consistent with various claims that these seaweeds can be used as remedies for inflammation-related symptoms.
doi_str_mv 10.1016/j.jep.2007.10.032
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Drug treatments</subject><subject>Sargassum</subject><subject>Sargassum - chemistry</subject><subject>Sargassum fulvellum</subject><subject>Sargassum thunbergii</subject><subject>Seaweed - chemistry</subject><subject>species differences</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1vFCEYB3BiNHZb_QBedC7qxVkfGAaY9NQ09SVp4qH2TBjmYctmXlZg1mzih5fNbOytHggv-fEP4U_IGwprClR83q63uFszAJn3a6jYM7KiSrJS1rJ6TlZQSVUqyekZOY9xCxlSDi_JGVUgG5ByRf5cjcnvDgGTt58KM5p-g3FZdnkkX_rR9WYYTJrCoTA2-b1PHmMxuSI9YBHR_EbsijsTNibGeSjc3O-x7_PqmPF4nh7mscWw8b7wYzF4i6_IC2f6iK9P8wW5_3Lz8_pbefvj6_frq9vScqFSKQwHB45WjehadJVrattayai1nIuONQ1VjZSWSdYx17WSu5rSumVADW2dqC7IxyV3F6ZfM8akBx9tfqMZcZqjlpIqxoGpLD88LYHVggv6X8ggBza0ypAu0IYpxoBO74IfTDhoCvrYot7q3KI-tng8yi3mO29P4XM7YPd441RbBu9PwERrehfMaH3853JWXSleZ_ducc5M2mxCNvd3-VsqACUk4zyLy0Vg_v-9x6Cj9Tha7HxAm3Q3-Sce-heYd8Rz</recordid><startdate>20080228</startdate><enddate>20080228</enddate><creator>Kang, J.Y.</creator><creator>Khan, M.N.A.</creator><creator>Park, N.H.</creator><creator>Cho, J.Y.</creator><creator>Lee, M.C.</creator><creator>Fujii, H.</creator><creator>Hong, Y.K.</creator><general>Elsevier Ireland Ltd</general><general>Amsterdam; New York: Elsevier</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20080228</creationdate><title>Antipyretic, analgesic, and anti-inflammatory activities of the seaweed Sargassum fulvellum and Sargassum thunbergii in mice</title><author>Kang, J.Y. ; Khan, M.N.A. ; Park, N.H. ; Cho, J.Y. ; Lee, M.C. ; Fujii, H. ; Hong, Y.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-6a40f0f1396dbef3f95cbc721cc446d29918977c272d2fdb74f5115b201a1bf63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>acute toxicity</topic><topic>algae and seaweeds</topic><topic>Analgesic</topic><topic>analgesic effect</topic><topic>Analgesics - pharmacology</topic><topic>Analgesics, Non-Narcotic - pharmacology</topic><topic>Animals</topic><topic>Anti-inflammation</topic><topic>anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antipyretic</topic><topic>antipyretics</topic><topic>Biological and medical sciences</topic><topic>Brown seaweed</topic><topic>dosage</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>General pharmacology</topic><topic>inflammation</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>oral administration</topic><topic>Pharmacognosy. 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source MEDLINE; Elsevier ScienceDirect Journals
subjects acute toxicity
algae and seaweeds
Analgesic
analgesic effect
Analgesics - pharmacology
Analgesics, Non-Narcotic - pharmacology
Animals
Anti-inflammation
anti-inflammatory activity
Anti-Inflammatory Agents - pharmacology
Antipyretic
antipyretics
Biological and medical sciences
Brown seaweed
dosage
Gas Chromatography-Mass Spectrometry
General pharmacology
inflammation
Medical sciences
medicinal plants
medicinal properties
Mice
Mice, Inbred BALB C
oral administration
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Sargassum
Sargassum - chemistry
Sargassum fulvellum
Sargassum thunbergii
Seaweed - chemistry
species differences
title Antipyretic, analgesic, and anti-inflammatory activities of the seaweed Sargassum fulvellum and Sargassum thunbergii in mice
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