Antipyretic, analgesic, and anti-inflammatory activities of the seaweed Sargassum fulvellum and Sargassum thunbergii in mice
Dichloromethane, ethanol, and boiling water extracts of the brown seaweeds Sargassum fulvellum and Sargassum thunbergii were examined for antipyretic, analgesic, and anti-inflammatory activities in mice. The activities were evaluated against yeast-induced pyrexia, tail-flick test, and phorbol myrist...
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container_title | Journal of ethnopharmacology |
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creator | Kang, J.Y. Khan, M.N.A. Park, N.H. Cho, J.Y. Lee, M.C. Fujii, H. Hong, Y.K. |
description | Dichloromethane, ethanol, and boiling water extracts of the brown seaweeds
Sargassum fulvellum and
Sargassum thunbergii were examined for antipyretic, analgesic, and anti-inflammatory activities in mice. The activities were evaluated against yeast-induced pyrexia, tail-flick test, and phorbol myristate acetate-induced inflammation (edema, erythema, and blood flow). The dichloromethane extract (0.4
mg/ear) of
Sargassum fulvellum inhibited an inflammatory symptom of mouse ear edema by 79.1%. The ethanol extract (0.4
mg/ear) of
Sargassum thunbergii also inhibited edema by 72.1%. No acute toxicity was observed after p.o. administration of each extract (5
g/kg
bw). These findings are consistent with various claims that these seaweeds can be used as remedies for inflammation-related symptoms. |
doi_str_mv | 10.1016/j.jep.2007.10.032 |
format | Article |
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Sargassum fulvellum and
Sargassum thunbergii were examined for antipyretic, analgesic, and anti-inflammatory activities in mice. The activities were evaluated against yeast-induced pyrexia, tail-flick test, and phorbol myristate acetate-induced inflammation (edema, erythema, and blood flow). The dichloromethane extract (0.4
mg/ear) of
Sargassum fulvellum inhibited an inflammatory symptom of mouse ear edema by 79.1%. The ethanol extract (0.4
mg/ear) of
Sargassum thunbergii also inhibited edema by 72.1%. No acute toxicity was observed after p.o. administration of each extract (5
g/kg
bw). These findings are consistent with various claims that these seaweeds can be used as remedies for inflammation-related symptoms.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2007.10.032</identifier><identifier>PMID: 18079077</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>acute toxicity ; algae and seaweeds ; Analgesic ; analgesic effect ; Analgesics - pharmacology ; Analgesics, Non-Narcotic - pharmacology ; Animals ; Anti-inflammation ; anti-inflammatory activity ; Anti-Inflammatory Agents - pharmacology ; Antipyretic ; antipyretics ; Biological and medical sciences ; Brown seaweed ; dosage ; Gas Chromatography-Mass Spectrometry ; General pharmacology ; inflammation ; Medical sciences ; medicinal plants ; medicinal properties ; Mice ; Mice, Inbred BALB C ; oral administration ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Sargassum ; Sargassum - chemistry ; Sargassum fulvellum ; Sargassum thunbergii ; Seaweed - chemistry ; species differences</subject><ispartof>Journal of ethnopharmacology, 2008-02, Vol.116 (1), p.187-190</ispartof><rights>2007 Elsevier Ireland Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-6a40f0f1396dbef3f95cbc721cc446d29918977c272d2fdb74f5115b201a1bf63</citedby><cites>FETCH-LOGICAL-c468t-6a40f0f1396dbef3f95cbc721cc446d29918977c272d2fdb74f5115b201a1bf63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874107005612$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20053845$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18079077$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, J.Y.</creatorcontrib><creatorcontrib>Khan, M.N.A.</creatorcontrib><creatorcontrib>Park, N.H.</creatorcontrib><creatorcontrib>Cho, J.Y.</creatorcontrib><creatorcontrib>Lee, M.C.</creatorcontrib><creatorcontrib>Fujii, H.</creatorcontrib><creatorcontrib>Hong, Y.K.</creatorcontrib><title>Antipyretic, analgesic, and anti-inflammatory activities of the seaweed Sargassum fulvellum and Sargassum thunbergii in mice</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Dichloromethane, ethanol, and boiling water extracts of the brown seaweeds
Sargassum fulvellum and
Sargassum thunbergii were examined for antipyretic, analgesic, and anti-inflammatory activities in mice. The activities were evaluated against yeast-induced pyrexia, tail-flick test, and phorbol myristate acetate-induced inflammation (edema, erythema, and blood flow). The dichloromethane extract (0.4
mg/ear) of
Sargassum fulvellum inhibited an inflammatory symptom of mouse ear edema by 79.1%. The ethanol extract (0.4
mg/ear) of
Sargassum thunbergii also inhibited edema by 72.1%. No acute toxicity was observed after p.o. administration of each extract (5
g/kg
bw). These findings are consistent with various claims that these seaweeds can be used as remedies for inflammation-related symptoms.</description><subject>acute toxicity</subject><subject>algae and seaweeds</subject><subject>Analgesic</subject><subject>analgesic effect</subject><subject>Analgesics - pharmacology</subject><subject>Analgesics, Non-Narcotic - pharmacology</subject><subject>Animals</subject><subject>Anti-inflammation</subject><subject>anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antipyretic</subject><subject>antipyretics</subject><subject>Biological and medical sciences</subject><subject>Brown seaweed</subject><subject>dosage</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>General pharmacology</subject><subject>inflammation</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>oral administration</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Sargassum</subject><subject>Sargassum - chemistry</subject><subject>Sargassum fulvellum</subject><subject>Sargassum thunbergii</subject><subject>Seaweed - chemistry</subject><subject>species differences</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1vFCEYB3BiNHZb_QBedC7qxVkfGAaY9NQ09SVp4qH2TBjmYctmXlZg1mzih5fNbOytHggv-fEP4U_IGwprClR83q63uFszAJn3a6jYM7KiSrJS1rJ6TlZQSVUqyekZOY9xCxlSDi_JGVUgG5ByRf5cjcnvDgGTt58KM5p-g3FZdnkkX_rR9WYYTJrCoTA2-b1PHmMxuSI9YBHR_EbsijsTNibGeSjc3O-x7_PqmPF4nh7mscWw8b7wYzF4i6_IC2f6iK9P8wW5_3Lz8_pbefvj6_frq9vScqFSKQwHB45WjehadJVrattayai1nIuONQ1VjZSWSdYx17WSu5rSumVADW2dqC7IxyV3F6ZfM8akBx9tfqMZcZqjlpIqxoGpLD88LYHVggv6X8ggBza0ypAu0IYpxoBO74IfTDhoCvrYot7q3KI-tng8yi3mO29P4XM7YPd441RbBu9PwERrehfMaH3853JWXSleZ_ducc5M2mxCNvd3-VsqACUk4zyLy0Vg_v-9x6Cj9Tha7HxAm3Q3-Sce-heYd8Rz</recordid><startdate>20080228</startdate><enddate>20080228</enddate><creator>Kang, J.Y.</creator><creator>Khan, M.N.A.</creator><creator>Park, N.H.</creator><creator>Cho, J.Y.</creator><creator>Lee, M.C.</creator><creator>Fujii, H.</creator><creator>Hong, Y.K.</creator><general>Elsevier Ireland Ltd</general><general>Amsterdam; New York: Elsevier</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20080228</creationdate><title>Antipyretic, analgesic, and anti-inflammatory activities of the seaweed Sargassum fulvellum and Sargassum thunbergii in mice</title><author>Kang, J.Y. ; Khan, M.N.A. ; Park, N.H. ; Cho, J.Y. ; Lee, M.C. ; Fujii, H. ; Hong, Y.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-6a40f0f1396dbef3f95cbc721cc446d29918977c272d2fdb74f5115b201a1bf63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>acute toxicity</topic><topic>algae and seaweeds</topic><topic>Analgesic</topic><topic>analgesic effect</topic><topic>Analgesics - pharmacology</topic><topic>Analgesics, Non-Narcotic - pharmacology</topic><topic>Animals</topic><topic>Anti-inflammation</topic><topic>anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antipyretic</topic><topic>antipyretics</topic><topic>Biological and medical sciences</topic><topic>Brown seaweed</topic><topic>dosage</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>General pharmacology</topic><topic>inflammation</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>oral administration</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Sargassum</topic><topic>Sargassum - chemistry</topic><topic>Sargassum fulvellum</topic><topic>Sargassum thunbergii</topic><topic>Seaweed - chemistry</topic><topic>species differences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, J.Y.</creatorcontrib><creatorcontrib>Khan, M.N.A.</creatorcontrib><creatorcontrib>Park, N.H.</creatorcontrib><creatorcontrib>Cho, J.Y.</creatorcontrib><creatorcontrib>Lee, M.C.</creatorcontrib><creatorcontrib>Fujii, H.</creatorcontrib><creatorcontrib>Hong, Y.K.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, J.Y.</au><au>Khan, M.N.A.</au><au>Park, N.H.</au><au>Cho, J.Y.</au><au>Lee, M.C.</au><au>Fujii, H.</au><au>Hong, Y.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antipyretic, analgesic, and anti-inflammatory activities of the seaweed Sargassum fulvellum and Sargassum thunbergii in mice</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2008-02-28</date><risdate>2008</risdate><volume>116</volume><issue>1</issue><spage>187</spage><epage>190</epage><pages>187-190</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Dichloromethane, ethanol, and boiling water extracts of the brown seaweeds
Sargassum fulvellum and
Sargassum thunbergii were examined for antipyretic, analgesic, and anti-inflammatory activities in mice. The activities were evaluated against yeast-induced pyrexia, tail-flick test, and phorbol myristate acetate-induced inflammation (edema, erythema, and blood flow). The dichloromethane extract (0.4
mg/ear) of
Sargassum fulvellum inhibited an inflammatory symptom of mouse ear edema by 79.1%. The ethanol extract (0.4
mg/ear) of
Sargassum thunbergii also inhibited edema by 72.1%. No acute toxicity was observed after p.o. administration of each extract (5
g/kg
bw). These findings are consistent with various claims that these seaweeds can be used as remedies for inflammation-related symptoms.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>18079077</pmid><doi>10.1016/j.jep.2007.10.032</doi><tpages>4</tpages></addata></record> |
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source | MEDLINE; Elsevier ScienceDirect Journals |
subjects | acute toxicity algae and seaweeds Analgesic analgesic effect Analgesics - pharmacology Analgesics, Non-Narcotic - pharmacology Animals Anti-inflammation anti-inflammatory activity Anti-Inflammatory Agents - pharmacology Antipyretic antipyretics Biological and medical sciences Brown seaweed dosage Gas Chromatography-Mass Spectrometry General pharmacology inflammation Medical sciences medicinal plants medicinal properties Mice Mice, Inbred BALB C oral administration Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Sargassum Sargassum - chemistry Sargassum fulvellum Sargassum thunbergii Seaweed - chemistry species differences |
title | Antipyretic, analgesic, and anti-inflammatory activities of the seaweed Sargassum fulvellum and Sargassum thunbergii in mice |
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