Metabonomic study on the toxicity of Hei-Shun-Pian, the processed lateral root of Aconitum carmichaelii Debx. (Ranunculaceae)

The purpose of this paper was to study the effects of Hei-Shun-Pian, the processed lateral root of Aconitum carmichaelii Debx. (Ranunculaceae), on the metabolic profile of rats, to discuss the mechanism of toxicology and to find out the potential biomarkers of the toxic effects. Twenty male Wistar r...

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Veröffentlicht in:	Journal of ethnopharmacology 2008-03, Vol.116 (3), p.561-568
Hauptverfasser:	Li, Ling, Sun, Bo, Zhang, Qi, Fang, Junjian, Ma, Kunpeng, Li, Yu, Chen, Hebing, Dong, Fangting, Gao, Yue, Li, Famei, Yan, Xianzhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitum Aconitum - chemistry Aconitum carmichaelii Alkaloids - analysis animal models Animals Biological and medical sciences biomarkers Blood - drug effects Blood Chemical Analysis blood chemistry dosage excretion General pharmacology heart Hei-Shun-Pian herbal medicines Magnetic Resonance Spectroscopy Male Medical sciences medicinal plants medicinal properties Metabolism metabolites metabolome metabolomics Metabonomics Multivariate analysis Naphthalenes - toxicity NMR spectroscopy oral administration Oriental traditional medicine Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - toxicity Plant Roots - chemistry Ranunculaceae Rats Rats, Wistar roots subacute toxicity Taurine temporal variation toxicity urine Urine - chemistry
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