Characterization of the pattern of inflammatory cell influx in chicks following the intraperitoneal administration of live Salmonella enteritidis and Salmonella enteritidis-immune lymphokines
We characterized the inflammatory cell influx in day-old chicks induced by the i.p. administration of live Salmonella enteritidis (SE) and lymphokines from concanavalin A-stimulated SE-immune T lymphocytes (ILK). An i.p. injection of ILK along with 5 X 10(3) cfu SE increased the survival rate of chi...
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| Veröffentlicht in: | Poultry science 1995-01, Vol.74 (1), p.8-17 |
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| creator | Kogut, M.H. (USDA, ARS, Food Animal Protection Research Laboratory, College Station, TX) McGruder, E.D Hargis, B.M Corrier, D.E DeLoach, J.R |
| description | We characterized the inflammatory cell influx in day-old chicks induced by the i.p. administration of live Salmonella enteritidis (SE) and lymphokines from concanavalin A-stimulated SE-immune T lymphocytes (ILK). An i.p. injection of ILK along with 5 X 10(3) cfu SE increased the survival rate of chicks 48 h later from 70% (ILK-treated controls) compared with 25% (saline-treated). The injection of both the ILK and live SE (but not formalinkilled SE) resulted in an increased influx of inflammatory heterophils into the peritoneum that peaked at 4 h after the injections with no increase in peritoneal macrophages. The heterophil accumulation was not influenced by polymyxin B, but was sensitive to heat treatment (100 C for 1 h) of the ILK, suggesting that lipopolysaccharide (LPS) did not contribute to the induced accumulation of heterophils. Treatment of the chicks with nordihydroguaiaretic acid or indomethacin did not abrogate the induced heterophil accumulation, suggesting that arachidonic acid metabolites were not involved in the SE/ILK-induced accumulation of peritoneal heterophils. The results from the current studies indicate that 1) ILK-mediated resistance to SE-induced mortality is mediated by a rapid influx of inflammatory heterophils to the site of infection; 2) live SE, during invasion, are vital for the site-directed migration of the heterophils; and 3) the mechanisms of induced heterophil accumulation are unknown but involve neither LPS nor arachidonic acid metabolites |
| doi_str_mv | 10.3382/ps.0740008 |
| format | Article |
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(USDA, ARS, Food Animal Protection Research Laboratory, College Station, TX) ; McGruder, E.D ; Hargis, B.M ; Corrier, D.E ; DeLoach, J.R</creator><creatorcontrib>Kogut, M.H. (USDA, ARS, Food Animal Protection Research Laboratory, College Station, TX) ; McGruder, E.D ; Hargis, B.M ; Corrier, D.E ; DeLoach, J.R</creatorcontrib><description>We characterized the inflammatory cell influx in day-old chicks induced by the i.p. administration of live Salmonella enteritidis (SE) and lymphokines from concanavalin A-stimulated SE-immune T lymphocytes (ILK). An i.p. injection of ILK along with 5 X 10(3) cfu SE increased the survival rate of chicks 48 h later from 70% (ILK-treated controls) compared with 25% (saline-treated). The injection of both the ILK and live SE (but not formalinkilled SE) resulted in an increased influx of inflammatory heterophils into the peritoneum that peaked at 4 h after the injections with no increase in peritoneal macrophages. The heterophil accumulation was not influenced by polymyxin B, but was sensitive to heat treatment (100 C for 1 h) of the ILK, suggesting that lipopolysaccharide (LPS) did not contribute to the induced accumulation of heterophils. Treatment of the chicks with nordihydroguaiaretic acid or indomethacin did not abrogate the induced heterophil accumulation, suggesting that arachidonic acid metabolites were not involved in the SE/ILK-induced accumulation of peritoneal heterophils. The results from the current studies indicate that 1) ILK-mediated resistance to SE-induced mortality is mediated by a rapid influx of inflammatory heterophils to the site of infection; 2) live SE, during invasion, are vital for the site-directed migration of the heterophils; and 3) the mechanisms of induced heterophil accumulation are unknown but involve neither LPS nor arachidonic acid metabolites</description><identifier>ISSN: 0032-5791</identifier><identifier>EISSN: 1525-3171</identifier><identifier>DOI: 10.3382/ps.0740008</identifier><identifier>PMID: 7899216</identifier><language>eng</language><publisher>England</publisher><subject>ACIDE ARACHIDONIQUE ; ACIDO ARAQUIDONICO ; Animals ; Arachidonic Acid - metabolism ; Cell Movement - immunology ; Chickens - immunology ; Chickens - microbiology ; FACTEUR IMMUNOLOGIQUE ; FACTORES INMUNOLOGICOS ; Female ; IMMUNITE CELLULAIRE ; INFLAMACION ; INFLAMMATION ; Inflammation - immunology ; Inflammation - veterinary ; INMUNIDAD CELULAR ; LEUCOCITOS ; LEUCOCYTE ; LINFOCITOS ; LIPOPOLISACARIDOS ; LIPOPOLYSACCHARIDE ; Lipopolysaccharides - pharmacology ; LYMPHOCYTE ; Lymphokines - immunology ; MACROFAGOS ; MACROPHAGE ; PERITOINE ; Peritoneal Cavity - cytology ; PERITONEO ; Phagocytes - physiology ; POLLITO ; Poultry Diseases - immunology ; POUSSIN ; SALMONELLA ENTERITIDIS ; Salmonella enteritidis - immunology ; Salmonella Infections, Animal - immunology</subject><ispartof>Poultry science, 1995-01, Vol.74 (1), p.8-17</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-5eee2aefc61d6d842df80340ee3f76f7dde245f765cf1b47bf177dbda4cf248f3</citedby><cites>FETCH-LOGICAL-c403t-5eee2aefc61d6d842df80340ee3f76f7dde245f765cf1b47bf177dbda4cf248f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7899216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kogut, M.H. (USDA, ARS, Food Animal Protection Research Laboratory, College Station, TX)</creatorcontrib><creatorcontrib>McGruder, E.D</creatorcontrib><creatorcontrib>Hargis, B.M</creatorcontrib><creatorcontrib>Corrier, D.E</creatorcontrib><creatorcontrib>DeLoach, J.R</creatorcontrib><title>Characterization of the pattern of inflammatory cell influx in chicks following the intraperitoneal administration of live Salmonella enteritidis and Salmonella enteritidis-immune lymphokines</title><title>Poultry science</title><addtitle>Poult Sci</addtitle><description>We characterized the inflammatory cell influx in day-old chicks induced by the i.p. administration of live Salmonella enteritidis (SE) and lymphokines from concanavalin A-stimulated SE-immune T lymphocytes (ILK). An i.p. injection of ILK along with 5 X 10(3) cfu SE increased the survival rate of chicks 48 h later from 70% (ILK-treated controls) compared with 25% (saline-treated). The injection of both the ILK and live SE (but not formalinkilled SE) resulted in an increased influx of inflammatory heterophils into the peritoneum that peaked at 4 h after the injections with no increase in peritoneal macrophages. The heterophil accumulation was not influenced by polymyxin B, but was sensitive to heat treatment (100 C for 1 h) of the ILK, suggesting that lipopolysaccharide (LPS) did not contribute to the induced accumulation of heterophils. Treatment of the chicks with nordihydroguaiaretic acid or indomethacin did not abrogate the induced heterophil accumulation, suggesting that arachidonic acid metabolites were not involved in the SE/ILK-induced accumulation of peritoneal heterophils. The results from the current studies indicate that 1) ILK-mediated resistance to SE-induced mortality is mediated by a rapid influx of inflammatory heterophils to the site of infection; 2) live SE, during invasion, are vital for the site-directed migration of the heterophils; and 3) the mechanisms of induced heterophil accumulation are unknown but involve neither LPS nor arachidonic acid metabolites</description><subject>ACIDE ARACHIDONIQUE</subject><subject>ACIDO ARAQUIDONICO</subject><subject>Animals</subject><subject>Arachidonic Acid - metabolism</subject><subject>Cell Movement - immunology</subject><subject>Chickens - immunology</subject><subject>Chickens - microbiology</subject><subject>FACTEUR IMMUNOLOGIQUE</subject><subject>FACTORES INMUNOLOGICOS</subject><subject>Female</subject><subject>IMMUNITE CELLULAIRE</subject><subject>INFLAMACION</subject><subject>INFLAMMATION</subject><subject>Inflammation - immunology</subject><subject>Inflammation - veterinary</subject><subject>INMUNIDAD CELULAR</subject><subject>LEUCOCITOS</subject><subject>LEUCOCYTE</subject><subject>LINFOCITOS</subject><subject>LIPOPOLISACARIDOS</subject><subject>LIPOPOLYSACCHARIDE</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>LYMPHOCYTE</subject><subject>Lymphokines - immunology</subject><subject>MACROFAGOS</subject><subject>MACROPHAGE</subject><subject>PERITOINE</subject><subject>Peritoneal Cavity - cytology</subject><subject>PERITONEO</subject><subject>Phagocytes - physiology</subject><subject>POLLITO</subject><subject>Poultry Diseases - immunology</subject><subject>POUSSIN</subject><subject>SALMONELLA ENTERITIDIS</subject><subject>Salmonella enteritidis - immunology</subject><subject>Salmonella Infections, Animal - immunology</subject><issn>0032-5791</issn><issn>1525-3171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UU1v1DAQtRBVWVouHJGQfOKAlNaOkzg5ohVfUiUObc_RbDzumvoj2A6w_Dn-Gt4PuHGa8XvPb0bzCHnJ2ZUQfX09pysmG8ZY_4SseFu3leCSPyUrxkRdtXLgz8jzlL4yVvOuk-fkXPbDUPoV-b3eQoQpYzS_IJvgadA0b5HOkAt4eBqvLTgHOcQdndDaA7L8LIVOWzM9JqqDteGH8Q-Hv8bnCHOxzMEjWArKGW9SAf9OsOY70luwrgisBYp-v0E2yiQKXv2Hqoxzi0dqd27ehkfjMV2SMw024YtTvSD3H97frT9VN18-fl6_u6mmholctYhYA-qp46pTfVMr3TPRMEShZaelUlg3bWnbSfNNIzeaS6k2CppJ102vxQV5c_SdY_i2YMqjM2l_C_AYljRKyXsuGS_Ct0fhFENKEfU4R-Mg7kbOxn1a45zGU1pF_Prkumwcqn_SUzyFf3XkNYQRHqJJ4_3t0Ao5NLX4A_wZoB0</recordid><startdate>199501</startdate><enddate>199501</enddate><creator>Kogut, M.H. (USDA, ARS, Food Animal Protection Research Laboratory, College Station, TX)</creator><creator>McGruder, E.D</creator><creator>Hargis, B.M</creator><creator>Corrier, D.E</creator><creator>DeLoach, J.R</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199501</creationdate><title>Characterization of the pattern of inflammatory cell influx in chicks following the intraperitoneal administration of live Salmonella enteritidis and Salmonella enteritidis-immune lymphokines</title><author>Kogut, M.H. (USDA, ARS, Food Animal Protection Research Laboratory, College Station, TX) ; McGruder, E.D ; Hargis, B.M ; Corrier, D.E ; DeLoach, J.R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-5eee2aefc61d6d842df80340ee3f76f7dde245f765cf1b47bf177dbda4cf248f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>ACIDE ARACHIDONIQUE</topic><topic>ACIDO ARAQUIDONICO</topic><topic>Animals</topic><topic>Arachidonic Acid - metabolism</topic><topic>Cell Movement - immunology</topic><topic>Chickens - immunology</topic><topic>Chickens - microbiology</topic><topic>FACTEUR IMMUNOLOGIQUE</topic><topic>FACTORES INMUNOLOGICOS</topic><topic>Female</topic><topic>IMMUNITE CELLULAIRE</topic><topic>INFLAMACION</topic><topic>INFLAMMATION</topic><topic>Inflammation - immunology</topic><topic>Inflammation - veterinary</topic><topic>INMUNIDAD CELULAR</topic><topic>LEUCOCITOS</topic><topic>LEUCOCYTE</topic><topic>LINFOCITOS</topic><topic>LIPOPOLISACARIDOS</topic><topic>LIPOPOLYSACCHARIDE</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>LYMPHOCYTE</topic><topic>Lymphokines - immunology</topic><topic>MACROFAGOS</topic><topic>MACROPHAGE</topic><topic>PERITOINE</topic><topic>Peritoneal Cavity - cytology</topic><topic>PERITONEO</topic><topic>Phagocytes - physiology</topic><topic>POLLITO</topic><topic>Poultry Diseases - immunology</topic><topic>POUSSIN</topic><topic>SALMONELLA ENTERITIDIS</topic><topic>Salmonella enteritidis - immunology</topic><topic>Salmonella Infections, Animal - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kogut, M.H. (USDA, ARS, Food Animal Protection Research Laboratory, College Station, TX)</creatorcontrib><creatorcontrib>McGruder, E.D</creatorcontrib><creatorcontrib>Hargis, B.M</creatorcontrib><creatorcontrib>Corrier, D.E</creatorcontrib><creatorcontrib>DeLoach, J.R</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Poultry science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kogut, M.H. (USDA, ARS, Food Animal Protection Research Laboratory, College Station, TX)</au><au>McGruder, E.D</au><au>Hargis, B.M</au><au>Corrier, D.E</au><au>DeLoach, J.R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of the pattern of inflammatory cell influx in chicks following the intraperitoneal administration of live Salmonella enteritidis and Salmonella enteritidis-immune lymphokines</atitle><jtitle>Poultry science</jtitle><addtitle>Poult Sci</addtitle><date>1995-01</date><risdate>1995</risdate><volume>74</volume><issue>1</issue><spage>8</spage><epage>17</epage><pages>8-17</pages><issn>0032-5791</issn><eissn>1525-3171</eissn><abstract>We characterized the inflammatory cell influx in day-old chicks induced by the i.p. administration of live Salmonella enteritidis (SE) and lymphokines from concanavalin A-stimulated SE-immune T lymphocytes (ILK). An i.p. injection of ILK along with 5 X 10(3) cfu SE increased the survival rate of chicks 48 h later from 70% (ILK-treated controls) compared with 25% (saline-treated). The injection of both the ILK and live SE (but not formalinkilled SE) resulted in an increased influx of inflammatory heterophils into the peritoneum that peaked at 4 h after the injections with no increase in peritoneal macrophages. The heterophil accumulation was not influenced by polymyxin B, but was sensitive to heat treatment (100 C for 1 h) of the ILK, suggesting that lipopolysaccharide (LPS) did not contribute to the induced accumulation of heterophils. Treatment of the chicks with nordihydroguaiaretic acid or indomethacin did not abrogate the induced heterophil accumulation, suggesting that arachidonic acid metabolites were not involved in the SE/ILK-induced accumulation of peritoneal heterophils. The results from the current studies indicate that 1) ILK-mediated resistance to SE-induced mortality is mediated by a rapid influx of inflammatory heterophils to the site of infection; 2) live SE, during invasion, are vital for the site-directed migration of the heterophils; and 3) the mechanisms of induced heterophil accumulation are unknown but involve neither LPS nor arachidonic acid metabolites</abstract><cop>England</cop><pmid>7899216</pmid><doi>10.3382/ps.0740008</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Poultry science, 1995-01, Vol.74 (1), p.8-17 |
| issn | 0032-5791 1525-3171 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | ACIDE ARACHIDONIQUE ACIDO ARAQUIDONICO Animals Arachidonic Acid - metabolism Cell Movement - immunology Chickens - immunology Chickens - microbiology FACTEUR IMMUNOLOGIQUE FACTORES INMUNOLOGICOS Female IMMUNITE CELLULAIRE INFLAMACION INFLAMMATION Inflammation - immunology Inflammation - veterinary INMUNIDAD CELULAR LEUCOCITOS LEUCOCYTE LINFOCITOS LIPOPOLISACARIDOS LIPOPOLYSACCHARIDE Lipopolysaccharides - pharmacology LYMPHOCYTE Lymphokines - immunology MACROFAGOS MACROPHAGE PERITOINE Peritoneal Cavity - cytology PERITONEO Phagocytes - physiology POLLITO Poultry Diseases - immunology POUSSIN SALMONELLA ENTERITIDIS Salmonella enteritidis - immunology Salmonella Infections, Animal - immunology |
| title | Characterization of the pattern of inflammatory cell influx in chicks following the intraperitoneal administration of live Salmonella enteritidis and Salmonella enteritidis-immune lymphokines |
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